a16z Podcast

  • Faster Science, Better Drugs

    Can we make science as fast as software?  In this episode, Erik Torenberg talks with Patrick Hsu (cofounder of Arc Institute) and a16z general partner Jorge Conde about Arc’s “virtual cells” moonshot, which uses foundation…


  • Ben Horowitz: Why Hesitation is a CEO’s Worst Enemy

    In this conversation from Lenny’s Podcast, Ben Horowitz joins Lenny to discuss the psychological muscle every founder needs, why hesitation can be fatal for CEOs, when it’s time to replace a founder, and how to…


  • Inside the $13T Mortgage Machine

    The $13T U.S. mortgage market serves 50M homeowners but still runs on decades-old software.  In this episode, a16z GP Angela Strange hosts Tim Mayopoulos (ex-CEO of Fannie Mae and ex-president of Blend), Mike Yu (co-founder…


  • Chris Dixon on How to Build Networks, Movements, and AI-Native Products

    Why do some consumer products explode into networks that reshape the internet, while others fade away? Today on the podcast, a16z general partners Anish Acharya and Chris Dixon take on that question. Anish invests in…


  • Mark Cuban on Sports, Healthcare, and Social Media

    What happens when AI collides with salesmanship, streaming-era sports, and healthcare? In this episode, Erik Torenberg is joined by Mark Cuban, entrepreneur, Dallas Mavericks co-owner, and founder of Cost Plus Drugs. Topics include fiery group…


  • The Little Tech Agenda for AI

    Who’s speaking up for startups in Washington, D.C.? In this episode, Matt Perault (Head of AI Policy, a16z) and Colin McCune (Head of Government Affairs, a16z) unpack the “Little Tech Agenda” for AI- why AI…


  • Building APIs for Developers and AI Agents

    Stainless founder Alex Rattray joins a16z partner Jennifer Li to talk about the future of APIs, SDKs, and the rise of MCP (Model Context Protocol). Drawing on his experience at Stripe—where he helped redesign API…


  • How to Be Free: Shaka Senghor, Oprah Winfrey, Ben Horowitz

    Taken from The Oprah Podcast, this special episode brings together Shaka Senghor, a16z cofounder Ben Horowitz, and Oprah Winfrey for a powerful conversation on resilience and transformation. Shaka, a resilience expert, motivational speaker, and bestselling…


  • Is Non-Consensus Investing Overrated?

    Is non-consensus investing overrated—or the secret to venture returns? a16z General Partner Erik Torenberg is joined by Martín Casado (General Partner, a16z) and Leo Polovets (General Partner, Humba Ventures) to unpack the debate that lit…


  • Jack Altman & Martin Casado on the Future of VC

    Jack Altman sits down with Martin Casado, General Partner at a16z, to unpack the shifting dynamics of venture capital and why media matters more than ever. They cover a16z’s evolution from generalists to specialized platforms,…


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