What’s Your Problem?

Robert Langer has co-founded dozens of companies, holds over a thousand patents, and is a pioneering figure in drug delivery and tissue engineering. Robert has solved a lot of problems, and is working on many more with his lab at MIT. But there is one big problem that has stuck with Robert his whole career: … Read more

Mateo Jaramillo is the co-founder and CEO of Form Energy. Mateo’s problem is this: How do you build batteries that can provide affordable backup power to the grid for days at a time? As it turns out, the basic technology was developed – and then mostly ignored – over 50 years ago. See omnystudio.com/listener for … Read more

This March, doctors successfully transplanted a pig kidney into a person for the first time in history. Mike Curtis is the CEO of eGenesis, the company that raised the pig whose kidney was used for the procedure. Mike’s problem is this: How do you genetically engineer pigs to provide organs – kidneys, hearts, livers – … Read more

Imagine picking up your phone and ordering something from Walmart. Fifteen minutes later, a drone hovers over your yard, lowers your order down to you, and zips away. Adam Woodworth wants this to be so boring you don’t even notice. He’s the CEO of Wing, a drone delivery company. His problem is this: How do … Read more

Psychedelics are going mainstream. The FDA has approved ketamine for certain patients with depression, and may soon approve MDMA for post-traumatic stress disorder (PTSD). But a fundamental question remains unclear: How do psychedelics work? Gul Dolen is a professor of psychology and neuroscience at UC Berkeley. In a series of experiments, Gul has found evidence … Read more

Kai Marshland is the co-founder and chief product officer at WindBorne Systems. Kai’s problem is this: How do you build weather balloons that can stay in the air for months at a time, and pair the data gathered by the balloons with AI to make weather forecasts that are way better than anything we have … Read more

Jonathan Hurst is a professor at Oregon State University, and co-founder and chief robot officer at Agility Robotics. Jonathan’s problem is this: How do you design a robot that can walk and do useful tasks that companies will pay for? The solution begins with trying to understand how birds walk. See omnystudio.com/listener for privacy information.

What does sickness sound like? Sometimes it’s obvious, like a cough, sniffle, or stuffy nose. But some conditions cause subtle changes that only a trained ear – or AI – can detect. Dr. Yael Bensoussan is a professor of otolaryngology and the director of the Health Voice Center at the University of South Florida. Her … Read more

Cement is, almost literally, everywhere. It is extraordinarily useful, which is why humanity makes 4 billion metric tons of it every year. But cement is also extremely carbon intensive to produce. Leah Ellis is the co-founder and CEO of Sublime Systems. Her problem is this: How can you make cement, at scale, without emitting carbon … Read more

Sam D’Amico is the founder and CEO of Impulse Labs, a company that makes induction stoves, with a clever twist. Sam’s problem is this: How do you build an electric cooktop that works just as well as gas, and can be installed without having to rewire the house? The solution that Sam found could eventually … Read more