What can we learn from the centuries-long quest to eradicate smallpox, once the scourge of humanity? And how did it set the stage for all vaccines to come? ...

Allon Bloch is the co-founder and CEO of K Health. Allon’s problem is this: Can you use AI to make seeing a doctor easier and more helpful? Today, thousands of ...

Sonia Kastner is the founder and CEO of Pano. Sonia’s problem is this: How do you use data and machine learning to mitigate the damage caused by climate ...

Amit Sharma is the founder and CEO of Narvar. Narvar works with companies such as Sephora, Lululemon and Home Depot to manage the post-purchase phase of online ...

Danielle Feinberg is a Visual Effects Supervisor at Pixar Animation Studios. Danielle’s problem is this: How do you optimize technology so that you can spend ...

Yaron Singer is the founder and CEO of Robust Intelligence. Yaron’s problem is this: How do you reduce AI’s security and reliability risks? Yaron was a ...

Chris Monroe is the co-founder and chief scientist of IonQ. Chris’s problem is this: How do you build a quantum computer that will actually work? Quantum ...

Seven stocks are powering the market: Alphabet, Amazon, Apple, Meta, Microsoft, Nvidia and Tesla. How will they do in the second half of this year? Ethan Wu ...

Charles Fisher is the co-founder and CEO of Unlearn AI. Charles’ problem is this: How do you build an AI model that can predict human health? Charles and his ...

Laura Modi is the founder and CEO of Bobbie, a company that makes baby formula and sells it directly to parents. Laura’s problem is this: how do you launch a ...

Xiao Wang is the founder of a company called Boundless. Xiao’s problem is this: How do you make it cheaper and easier for people to navigate the U.S. ...

Henrik Stiesdal got his start in wind power back in the 70s. The price of oil had gone way up, and he wanted to help his parents figure out a cheaper source of ...

One of the most amazing things about ChatGPT and other, similar AI models: Nobody really understands what they can do. Not even the people who build them. On ...

Dan Friedmann is the CEO of Carbon Engineering. The company is at the frontier of a new industry, direct air capture. They just broke ground on a big plant in ...

Does flying have to be bad for the environment? Val Miftakhov, the founder and CEO of ZeroAvia, doesn’t think so. His company built a plane that’s powered by ...

Andrew Mason is the founder and CEO of Descript. Descript’s software has made editing audio and video much simpler.  The company recently received a ...

Andrew Ponec is co-founder and CEO of the energy storage company Antora Energy.  Andrew’s problem is this: How can you store renewable energy in a way ...

Tammy Hsu and Michelle Zhu are the cofounders of Huue.  Their problem is this: how do you get bacteria to produce indigo dye? And how do you do it cheaply and ...

Today’s show is about a problem people have been trying to solve for a hundred years: how can we mass produce houses, like we do cars? Listen for a house ...

Alexis Rivas is the co-founder and CEO of Cover. His problem is: How do you build houses in a factory, the way you build cars? And how do you do it so ...