Author: a16z Podcast

  • How a16z’s Crypto Startup School Went Remote

    AI transcript
    0:00:03 Hi everyone, I’m Zoran Basic, our crypto editor.
    0:00:07 On February 21st, our team kicked off its very first crypto startup school.
    0:00:10 We invited dozens of instructors and mentors
    0:00:14 and 45 students who applied and were selected from around the U.S. and three countries
    0:00:17 for a seven-week course to learn how to build crypto projects.
    0:00:22 But just two weeks in, community spread of the coronavirus in our area started happening,
    0:00:25 and as much as we loved having everyone gathered together in one place,
    0:00:29 we decided to go remote, not just for the health and safety of everyone involved,
    0:00:33 but for others too, given the recommendations around social distancing
    0:00:35 and the importance of flattening the curve.
    0:00:37 So I did a short hallway-style chat,
    0:00:41 though in this case the hallways are all remote since A16Z has gone remote,
    0:00:45 with crypto marketing partner Kim Milosevic and Jesse Walden,
    0:00:49 former founder of MediaChain, who’s helping lead our crypto startup school effort.
    0:00:51 We begin with Kim sharing her thoughts,
    0:00:54 since so many others are going through this for their own events.
    0:00:59 So the idea of moving a remote wasn’t something I was excited about at first,
    0:01:03 because the first week, you know, it was clear that the excitement in the room,
    0:01:08 like everybody was just so thrilled to be there and you could feel the energy.
    0:01:11 You know, we kicked off the program and everybody was applauding.
    0:01:15 You know, everybody was just so excited to be there with each other.
    0:01:21 We had put a lot of emphasis on having these 45 students here in person
    0:01:25 for the benefit of really learning from each other and being part of something.
    0:01:29 And to then learn that this whole thing is going to go virtual,
    0:01:35 my first thought was just how do we continue to have that sort of feeling
    0:01:38 and create that kind of atmosphere for people.
    0:01:42 And then it just really became, it’s very complicated, right?
    0:01:46 We worked through it, it took a lot of us coming together,
    0:01:49 many phone calls and figuring out all of our resources.
    0:01:55 It’s really just the minutiae of the audio, the video.
    0:01:58 How do we make that kind of a seamless experience?
    0:02:02 And then also make sure these students feel like they still have a voice
    0:02:06 and that they can still jump in and feel like they’re part of something.
    0:02:11 So it went from like, oh, no, we put this emphasis on being in person
    0:02:14 and creating a community with these students to all of a sudden the minutiae
    0:02:22 of all the complicated logistics that goes into pulling off a virtual experience.
    0:02:27 And we just don’t want to lose people and make them feel like they’re just on a conference call.
    0:02:28 Yeah, and that was the big thing, right?
    0:02:30 Because the energy was so good,
    0:02:34 we wanted to somehow preserve this sort of live feel as best we could.
    0:02:37 So we took the videographers that we had
    0:02:40 who were going to be capturing everything we were going to be doing in person
    0:02:47 and try to set up as much of a kind of live in person experience even though it was remote.
    0:02:52 So we had, like you said, a minutiae of sorts where we had the videographers
    0:02:57 capturing high quality video of the people that we had in person
    0:03:03 while also trying to capture as much high quality content of folks that were remote.
    0:03:08 So in the case of last week, for example, we actually had a video crew in New York
    0:03:13 for our speaker, Sam Williams, from our weave who was there in New York
    0:03:15 and wasn’t able to fly out here.
    0:03:20 And then in some cases, we were not able to have a videographer on site.
    0:03:22 For example, the case with biology.
    0:03:30 So we had to create as much of a high quality zoom in experiences because I do want to go back to the students.
    0:03:34 What was their reaction to going remote and all the all the different things
    0:03:36 that they’re going to have to navigate as you were talking to them through this?
    0:03:43 Well, I think actually a lot of them were relieved because they themselves were concerned about the virus.
    0:03:52 Others were, I guess, disappointed that they were going to be missing out on some of the in-person get-togethers that we had planned.
    0:03:58 And so they took it upon themselves to plan get-togethers for those that were comfortable continuing in person.
    0:04:03 And so we had a group watching the live stream from one of the students’ apartment.
    0:04:05 I think it was a group of like six or seven or so.
    0:04:10 And so that’s great. I think there’s people with varying levels of comfort
    0:04:13 and remote just gives everyone flexibility and options, which is nice.
    0:04:18 You touched on almost the team feeling among all the students.
    0:04:21 And we noticed that just in the first two weeks, right, they really came together.
    0:04:27 It was a very boisterous, fun, engaged environment during the in-session, in-person classes.
    0:04:37 Yeah, well, so as I mentioned earlier, we were doing Q&A with the speakers, and that portion of the session was very engaged.
    0:04:39 Or there was a lot of engagement from students.
    0:04:44 And I think one thing we didn’t quite account for is how to sort of wind down the session.
    0:04:48 And so what ended up happening is a student reached out on Slack saying,
    0:04:52 “Hey, it’d be really nice if we could all somehow cool off from the session.”
    0:04:57 And I think what we ended up doing on Slack is asking people to sort of express
    0:05:01 how they’re feeling about the session through emojis, which is lower bandwidth
    0:05:06 than an in-person discussion, but I think still carries a lot of information with it.
    0:05:13 And so going forward to address that better, we created a channel with a bot
    0:05:17 that pairs students one-on-one so that they can sort of talk with one another after the session
    0:05:22 or between sessions so that they still feel like they’re getting a lot of face time with others
    0:05:25 in the program, because that’s clearly important.
    0:05:27 What were your interactions like with the students as this was being announced
    0:05:29 and was actually happening?
    0:05:33 I think some of them actually prefer the sort of asynchronous nature of the communication
    0:05:38 that they’re having now on Slack, because it allows for sort of everyone to participate
    0:05:43 in the conversation as opposed to having breakout groups or limited time
    0:05:45 for folks to interact with one another.
    0:05:49 So talk a bit about that, just the way you set up communications and the Slack channel
    0:05:52 and other collaborative tools you had to use to keep people engaged.
    0:05:57 Right. So with Zoom, we’re specifically using a feature called Breakouts
    0:06:02 that allows the whole group to come together, but then also breakout into smaller groups
    0:06:08 to discuss what they’re learning, give feedback to one another in a more personal setting.
    0:06:14 In addition, we’ve been supplementing that with Slack to do Q&A with instructors
    0:06:20 so that we can moderate a sort of useful discussion after presentations as opposed
    0:06:25 to having sort of a cock-a-phoney of folks on a video chat trying to talk over each one another.
    0:06:31 And the benefit of having questions come in on Slack is we can get to every single one.
    0:06:34 Instructors can follow up with as much detail as they’d like.
    0:06:37 Students can chime in, ask follow-up questions.
    0:06:41 And so it’s actually turned out to be sort of a much richer experience.
    0:06:47 And then on the actual sort of logistics of setting up the video stuff, for me,
    0:06:54 that was sort of fun because it reminded me of experience that I had back in 2012
    0:06:57 or so where I was running this thing called Boiler Room,
    0:07:00 where we would broadcast live music performances on the internet.
    0:07:06 And so similarly, we’d have basically a portable TV station that we’d bring to some warehouse
    0:07:12 and film DJs or musicians performing live to an online audience and try to–
    0:07:15 there was tons of online engagement through a chat box there.
    0:07:19 So kind of a similar setup many years later in a different industry,
    0:07:21 but I guess that was good preparation.
    0:07:23 Well, this is kind of the bigger picture, right?
    0:07:26 Because so many events have been canceled in recent weeks.
    0:07:28 You know, right around the time that we went remote,
    0:07:32 like South by Southwest was canceled, you know, huge event.
    0:07:36 And more and more companies are having employees work from home.
    0:07:40 It seems like this could be almost like an inflection point where this becomes more
    0:07:43 of a thing that people want to do and see that it should be done in terms
    0:07:48 of different kinds of virtual conferences, even though the appeal
    0:07:51 of a conference is supposedly you go and you network and you meet people that you don’t know.
    0:07:53 Yeah, absolutely.
    0:07:59 I mean, I think that the coronavirus certainly is what prompted us to move this whole thing virtual.
    0:08:02 But, you know, I think it has been–
    0:08:05 it’s something that we actually were really excited to experiment with.
    0:08:08 And, you know, so coronavirus is a forcing function,
    0:08:12 but it’s a really good muscle to build for us to learn how to do this
    0:08:16 and how we can scale it and what works, what doesn’t work.
    0:08:19 And, you know, as Jesse pointed out, one of the things that we’re now thinking
    0:08:23 about moving forward is, you know, how do we make sure that we continue
    0:08:26 to have as much interaction as possible, right?
    0:08:29 The sort of one-to-many broadcast is important for the content.
    0:08:33 And you want that to be a good experience for the people that are participating.
    0:08:36 But then, again, we have these students and part of the goal
    0:08:40 of this whole crypto startup school is for them to interact and learn from each other.
    0:08:44 So how do we, you know, make that possible, you know, as much as we can moving forward
    0:08:48 when we don’t have specifically a workshop element, for example.
    0:08:53 So we’re now trying to think of creative ways to have people still break out in groups,
    0:08:54 still interact with one another.
    0:08:56 How do we prompt people for questions?
    0:09:00 How do we get really clever with how we use Slack?
    0:09:04 You know, how do we keep people engaged there and prompt questions there?
    0:09:08 And so they’re still like– we’re still experimenting with a lot of different things here.
    0:09:13 But hopefully we can figure out some smart ways to use it in other ways, too,
    0:09:15 other than crypto startup school.
    0:09:20 So in the midst of all this, two or three days after our first remote session,
    0:09:24 A16Z itself went remote, meaning employees weren’t going to the office
    0:09:27 like many companies around the Bay Area and around the country.
    0:09:29 We were encouraged to work from home.
    0:09:33 So that added sort of another layer of complexity because here we are trying to figure
    0:09:38 out all these logistical issues and experiment in all these new ways
    0:09:42 with a remote conference, and we’re all working remotely as well.
    0:09:46 Yeah, I think we’re all sort of figuring this out what this new world is like.
    0:09:51 And we’re trying tools like tandem where they have these water cooler functions
    0:09:59 where you can sort of be in a room with folks and just kind of chat with each other spontaneously.
    0:10:03 And we’re all, I think, all trying to figure out making sure we have time to eat.
    0:10:06 I know myself included in others are saying like,
    0:10:11 I didn’t actually lunch until three o’clock or, you know, when do you, you know,
    0:10:13 just completely changes your whole daily schedule.
    0:10:15 So just trying to figure that out.
    0:10:19 But then also trying to create some guidelines because there’s not really
    0:10:23 these clear start and end times like you have going in and out of an office.
    0:10:26 And while I think in tech, we all kind of work 24/7.
    0:10:29 I found it, I don’t know what your guys’ experience is,
    0:10:34 but even that much more difficult of, you know, having sort of a as much
    0:10:37 of a beginning and an end to your work days you can.
    0:10:41 Yeah, it’s so easy for work to bleed into life and vice versa, even more than usual.
    0:10:43 And one thing people kept bringing up was sort of like,
    0:10:46 I need to remind myself to get out of the house and take a short walk
    0:10:49 because otherwise you’re head down all day and you realize I haven’t been outside.
    0:10:52 Yeah, in some ways, it’s funny as I think like you you’re worried
    0:10:55 that you’re not going to be in touch with each other as much.
    0:10:59 But in reality, I think I’m actually talking to people more.
    0:11:03 I think I’m on phone calls all day long, whereas in the office,
    0:11:06 you might run into people or you have a moment that you you also have.
    0:11:10 You have, you know, maybe a block of time or you can just kind of be at your desk
    0:11:16 and get some stuff done, whereas, you know, it feels like I’ve been on the phone constantly.
    0:11:22 Yeah, I myself found found that I hadn’t been outside for, I guess,
    0:11:25 like 30 hours or something like that.
    0:11:28 So I was starting to get a little stir crazy and had to go for a walk.
    0:11:32 You know, I think it’s interesting because I’ve had some experience
    0:11:36 with remote work before my startup, we ran sort of a remote process.
    0:11:40 And so it’s not surprising to me that this sort of changes.
    0:11:42 I think I’m familiar with them.
    0:11:45 But it is it is interesting to see it happening on the scale
    0:11:52 and within Andrews and Horowitz, where, you know, remote culture was not sort of a primary reflex.
    0:11:55 So I think we’re developing a muscle for it.
    0:12:00 And yet it’ll be interesting to see how that muscle if that muscle sticks around.
    0:12:02 I think it is a culture question.
    0:12:07 I’ve heard of startups who have a really pro remote culture, including one
    0:12:11 that I worked at in which they really took pains till I include everyone who was remote
    0:12:15 and make sure that they were not sort of second class citizens to people who worked in the office.
    0:12:18 And that included things like, you know, when people in the office got swag,
    0:12:22 you made sure to send it to the people remote and just little things like that
    0:12:25 or having virtual happy hours, little things like that, I think,
    0:12:28 go a long way toward making a team feel unified.
    0:12:33 So one of the perhaps ironies of this is that crypto itself is very decentralized.
    0:12:37 And we ended up having a decentralized conference.
    0:12:41 It’s a muscle that a lot of our portfolio projects, I think, have already developed to some extent.
    0:12:46 And of course, like when building a startup, going fully remote is a decision
    0:12:48 that needs to be weighed carefully because there’s a lot of tradeoffs
    0:12:53 that founders and sort of leaders of these projects need to anticipate.
    0:12:57 But the fact is that crypto is sort of this worldwide movement.
    0:13:00 These are sort of open networks where anyone can participate.
    0:13:03 And as a result, there’s a lot more geographic distribution.
    0:13:07 And so I think, you know, we’re learning something that the crypto community
    0:13:10 has been been learning from the get go, which is how to how to coordinate
    0:13:14 a really decentralized group of people towards an outcome that everyone wants.
    0:13:19 So, you know, obviously it was a bit of disappointment and a bit of a scramble to make it happen.
    0:13:21 But I think we’re pulling it off.
    0:13:23 Kim and Jesse, thanks so much. Talk to you soon.
    0:13:24 Thank you.

    On February 21, Andreessen Horowitz kicked off its very first Crypto Startup School, with 45 students from around the U.S. and three countries gathering to learn how to build crypto projects. But just two weeks into the seven-week course, community spread of the novel coronavirus meant the school had to go remote — not just for the health and safety of everyone involved, but for others too, given the recommendations around social distancing and the importance of “flattening the curve”.

    Marketing partner Kim Milosevich and Jesse Walden, former founder of Mediachain who’s helping lead our Crypto Startup School, chat with a16z crypto editor Zoran Basich — in this hallway-style episode of the a16z Podcast — about virtual learning and collaboration in a new, uncharted world.

  • When Fintech Meets Social

    AI transcript
    0:00:05 The content here is for informational purposes only, should not be taken as legal business
    0:00:10 tax or investment advice or be used to evaluate any investment or security and is not directed
    0:00:15 at any investors or potential investors in any A16Z fund. For more details, please see
    0:00:21 A16Z.com/disclosures. Hi, and welcome to the A16Z podcast. I’m Lauren Murrow, and today
    0:00:26 we’re talking about when fintech meets social. It’s a trend that’s evident on both ends
    0:00:30 of the spectrum, whether that’s people divulging their crushing levels of debt on Instagram
    0:00:35 and Twitter or bragging about their credit scores and stock trades. In this hallway-style
    0:00:39 conversation with fintech general partner Anish Acharya and Darcy Kulikin, a partner on the
    0:00:46 consumer tech team, we discuss why this holy grail of social plus fintech is both so challenging
    0:00:50 and potentially so rewarding. We’ll cover which products and companies are taking advantage
    0:00:55 of it, how it’s being driven by various subcultures online, and why this shift is happening now,
    0:00:59 which is where this conversation begins. The first voice you’ll hear is Anish, followed
    0:01:02 by Darcy. So the fact that people are actually talking
    0:01:07 publicly about their debt is a new behavior. In the past, spending was public, but debt
    0:01:12 was private. And for the first time, debt is starting to become a public conversation.
    0:01:17 What’s new is that this generation is living in a completely different socioeconomic context.
    0:01:21 That’s not flighty millennials and zoomers or whatever. That’s a completely different
    0:01:25 financial world that they’re growing up in, and that’s driving a different set of conversations.
    0:01:29 You see certain categories that people are now talking about that they didn’t talk about
    0:01:33 before. Salary is something that a certain generation is much more comfortable talking
    0:01:38 about. Student debt is a category that people are much more comfortable talking about. Trading
    0:01:42 is a category that people are much more comfortable talking about. Across the spectrum, you see
    0:01:48 sharing on social of financial stuff going up. You see it on Twitter, you see it on Facebook,
    0:01:51 you see it in blogs. There’s a bunch of pockets.
    0:01:57 Why do you think this shift is happening? I think it’s driven by a few factors. One
    0:02:02 is generational. Every generation’s relationship with sharing and every generation’s relationship
    0:02:06 with money is different. So what boomers did versus what Gen X did versus what millennials
    0:02:11 do versus what Gen Z does is different. And I think you see this macro trend around increasing
    0:02:15 sharing. And that’s driven by historical changes. That’s driven by the financial crisis.
    0:02:20 Exactly. They have to take nontraditional paths to achieve financial progress and dreams.
    0:02:25 For a long, long time, buying a home was not only the American dream, but something you
    0:02:29 achieved through the traditional financial system. So everyone had a mortgage. Today
    0:02:33 mortgages are less accessible than they’ve ever been. Will you talk to your peer set
    0:02:37 about how am I ever going to buy a home? And that’s really the catalyst behind many of
    0:02:39 these things. And I think you see that also with the massive
    0:02:44 increase in student debt over the last 10, 15 years. It’s reaching unsustainable levels
    0:02:48 and that’s forcing a conversation. And then that breaks down the stigma about talking
    0:02:51 about student debt. And then once you break the stigma, then it’s like, hold on and everything
    0:02:55 comes flooding to the forefront. We’ve talked about how money is inherently
    0:03:01 private. Do you not think that that is becoming less so? There’s a generational piece of it.
    0:03:05 Then yes, we’re sharing more of our lives in general. And then there’s a political angle
    0:03:09 to it, this idea of radical transparency to affect change. So that’s why we’re posting
    0:03:13 more about student debt, about medical debt, about our salaries.
    0:03:19 Usually there is a long-term trend line towards sharing more rather than sharing less. But
    0:03:24 you see it happening at the category level and to a certain extent at the subculture
    0:03:28 level. So take student debt as one category. When people start talking about it, then everybody
    0:03:34 feels empowered to talk about it. And I think you need catalysts for walls to come down around
    0:03:38 certain categories like the student debt crisis, a financial crisis. There’s a lot of external
    0:03:42 events that have led to some of these things come down, but it’s happening inch by inch
    0:03:46 and category by category. And the question is, what pieces are going mainstream?
    0:03:52 I think the hacker mindset has pushed outside of software and into finance. There is always
    0:03:57 a small number of people who are excited about hacking their money, but now that’s becoming
    0:04:02 a more mainstream concept. So the idea of being someone who arbitrages rewards across
    0:04:07 credit cards used to be a pretty niche edge thing. And now more and more people are doing
    0:04:10 it to the point where a lot of card companies are having to pull rewards back because there’s
    0:04:14 a points guy and a million other sites that tells you how to actually hack the system.
    0:04:19 And credit scores are very similar. It’s not a destiny. It’s a game, or it’s at least closer
    0:04:23 to a game than a destiny. And more people are talking about the ways that you play it.
    0:04:28 When I say it’s a game, I say that in a hopeful way, but not in a dismissive way in terms of
    0:04:29 the importance of it.
    0:04:32 It also goes to what are the things people like to do on social? And three of the core
    0:04:37 functions are bragging, complaining, and rubbernecking. And I just think you’ve seen where social and
    0:04:42 finance intersect, kind of coalescing around those three use cases as well.
    0:04:45 At the end of the day, social and finance, a lot of it is just content, and it’s content
    0:04:49 that’s anchored around some financial transaction, but it’s still just content. And so the usual
    0:04:53 rules of social apply. Another way to think about it is, when you’re building something
    0:04:58 in social plus finance, you have an interaction layer, and you have a transaction layer. And
    0:05:02 the interaction layer is built around the emotional and cognitive pieces. And that is
    0:05:06 content creation, that is messaging, that is all these social things that we see pop
    0:05:11 up that appeal to these cognitive and emotional levers. And then you have a transactional
    0:05:15 layer, which is whatever your actual financial transaction is. And that’s generally much
    0:05:21 more of a functional use case. The magic in social plus finance happens when the transactional
    0:05:25 piece and the interactive piece are mutually reinforcing, and that’s where the flywheel
    0:05:29 on social plus finance really starts to spin aggressively.
    0:05:33 Can you give me some examples of particular products in which you’ve seen this magic happen?
    0:05:38 The easiest example is probably Venmo back in the day, where you had messaging apps,
    0:05:42 money transfer apps like PayPal existed, and Chat existed, but the idea that you could
    0:05:46 attach your transaction to an emoji just made the transaction easier, it made the emoji
    0:05:51 more fun, it made the whole thing more self-reinforcing. It’s a really challenging problem to be able
    0:05:53 to do that, but when you do do it, it’s magic.
    0:05:58 I actually think that those products are fascinating. I still like to scroll through the global
    0:06:03 feed on Venmo, which now is capped at the last 50 transactions, but it’s just so fascinating
    0:06:07 to see all of these people all over the country sending each other money. There’s something
    0:06:13 that is just vicariously thrilling about it, and because money does touch all of us, and
    0:06:17 it’s so private, and the products that can start to invert that, I think they just touch
    0:06:21 a nerve in an interesting way. And by the way, it doesn’t have to only be online. So there’s
    0:06:27 a couple of interesting offline examples, SoFi, which is really in the business of refinancing
    0:06:34 mispriced student debt, built this whole community of Henry’s, high earning, not rich yet, did
    0:06:40 a ton of parties and events, and made it feel special to be a SoFi member, and really they
    0:06:45 were a lender. So I think they’ve actually, at least in the early days, had a lot of success
    0:06:51 combining the two. I imagine it’s less successful as Capital One is now opening coffee shops
    0:06:56 where you can hang out and get coffee and do your banking, I guess, and it’s easy to
    0:07:00 dismiss that as clumsy, but I do think that they’re trying to touch the same nerve.
    0:07:06 There’s also this long legacy of companies starting out at the nexus of social and fintech,
    0:07:10 and then eventually moving one way or the other generally towards the fintech transactional
    0:07:14 layer. So a lot of people who can build either features or community in the early days and
    0:07:19 really use it as a way to bootstrap their product, but then over time it migrates more
    0:07:23 towards a transactional fintech product rather than a truly social product as well.
    0:07:24 What are some of those examples?
    0:07:28 SoFi is a great example. It’s functionally a lender, which is not a multiplayer social
    0:07:31 game, but they were able to build this early community, which is able to get them a lot
    0:07:35 of traction. You look at Wealthfront. Before it transitioned into Wealthfront, I think it
    0:07:40 started as Ka-ching, which was a social fintech product. If you look Robinhood originally,
    0:07:45 it was a much more social product, then became a much more transactional product. Prosper
    0:07:48 started as a much more social product, and then became more of a peer-to-peer lending
    0:07:53 platform. A lot of these things start social and are able to bootstrap in their early days
    0:07:57 off of some of those networks. Then you end up at a decision point where you try to thread
    0:08:01 this needle and continue down the social plus finance angle, or do you move into a more
    0:08:05 single-player fintech product? I think a lot of the more successful fintech companies have
    0:08:07 started social, but then eventually transitioned.
    0:08:09 Why are they making that transition?
    0:08:10 It’s hard.
    0:08:14 Well, let’s talk about it. What is so hard about social fintech?
    0:08:19 The most direct manifestation of social plus fintech is we have messaging, plus we have
    0:08:24 payments or some other shared accounts, shared ledgers, some other joint accounts, et cetera.
    0:08:29 I think that is very difficult for a number of reasons because money is so private. People
    0:08:35 are less likely to send invites to each other and bootstrap a social product in the way
    0:08:39 that you would bootstrap other social products.
    0:08:43 I think there’s a lot of other examples, though, where the experience may not directly represent
    0:08:48 social plus money, but it very much plays to that. I think the example Darcy brought up
    0:08:52 is great, which is Robinhood. There’s been a ton of talk about how Robinhood is doomed
    0:08:57 because others have cut fees and adopted their business model, but in truth, Robinhood is
    0:09:02 a game, and it’s a game that people like to talk about. It works because it feels like
    0:09:06 adulting when you actually have a stock portfolio, not because active trading is something that’s
    0:09:12 smart for almost anyone to do. I really see it as addressing a different consumer need
    0:09:17 than Schwab is addressing, and it’s really not threatened as much by players like Schwab.
    0:09:23 That’s an example where the fintech product is addressing a social consumer need, but
    0:09:27 at first blush, it may not appear to be the combination of social plus money.
    0:09:32 Some of these products are really tapping into the trend for its gamification. Do you
    0:09:36 think more products will go that route and design around that impulse that we have?
    0:09:41 I think the thing you will likely see is that these social plus fintech products will actually
    0:09:45 come much more from the consumer side of things. I think there’s some things like Robinhood
    0:09:50 where you are able to build both fintech and community, and it comes from the fintech side
    0:09:53 of things. Another encouraging angle to it is the things that are coming from the social
    0:09:57 side. Whether it’s a bunch of the chat apps that now have wallets and payments installed
    0:10:00 in them, or even something as weird as Fortnite, which is technically a game, but they have
    0:10:05 V-Bucks, and they have these economies built into them. It’ll be fascinating to see what
    0:10:09 happens with those types of products, because that could be the actual place where we see
    0:10:10 social plus money take off.
    0:10:14 I do think, by the way, there’s been a bunch of past attempts, which maybe seem naive at
    0:10:19 the time, but now just seemed like bad timing. Blippi is a famous example of this where it
    0:10:23 tweeted everything that you bought, linked your credit card, and every time you swiped
    0:10:29 it, it tweeted. Okay, there’s obvious reasons why that might not be a good idea, and yet
    0:10:30 I think the fact that…
    0:10:31 It’s too soon.
    0:10:34 Hey, look, the fact that Dave Ramsey exists, and people are talking about debt and spending,
    0:10:39 and there’s the nugget of truth in all these things. As Mark says, it’s rarely that the
    0:10:42 idea is wrong. It’s usually that the timing is.
    0:10:46 One of the interesting things about this category of company is that if you just take a step
    0:10:50 back and you’re looking for a broader consumer trends, you can often look at little emergent
    0:10:53 behaviors that are happening somewhere on the internet and try to figure out, is that
    0:10:56 going to actually go into the mainstream at some point?
    0:11:00 One of the interesting and challenging things about social plus fintech is that so much
    0:11:04 of it is driven by norms, so much of it is driven around what’s taboo and what’s stigmatized,
    0:11:09 and that actually exists at the subculture level. You can grow up in the same town at
    0:11:13 the same age, and if you grow up on one side of town, your norms around money and sharing
    0:11:16 are very different from the person on the other side of town.
    0:11:20 That leads to a lot of very distinct subcultures within different pockets on the internet.
    0:11:24 One of the more entertaining one is All Street Bets on Reddit, where people are posting some
    0:11:29 mix of fake and real trades and explosions and everything like that, and so then you
    0:11:32 can look at these things and say, “Oh, here’s this crazy emergent behavior that’s happening.
    0:11:36 I think this is going to go mainstream.” In some cases, it will, or in some cases, it
    0:11:40 is just part of that subculture because the norms and taboos will never translate into
    0:11:46 the mainstream, but when those stigmas fall, then everything happens and everybody runs
    0:11:48 for the entrance at that point.
    0:11:52 Yeah, it is interesting. If you think about crypto, so this crypto as a computing platform,
    0:11:57 which is how we talk about it a lot internally, but then there’s also the sort of socio-political,
    0:12:02 perhaps anarchist thread of crypto. I think the historical example of that was mostly
    0:12:03 gold, though at the end is taboo.
    0:12:07 Nobody was screencapping their Boolean collection and sharing it on Twitter.
    0:12:13 Well, depending on what Facebook group you’re in. I think, again, there is a past precedent,
    0:12:17 but you’re right. There’s a functional aspect of hedging against things that may go badly
    0:12:22 wrong in the future, and then there’s a cognitive, emotional, socio-political to your point, Lauren.
    0:12:25 Crypto is fascinating because it’s a subculture that has a totally different relationship with
    0:12:30 transparency and anonymity and all of these different dimensions and just changing the
    0:12:36 form factor of value from a dollar to some sort of token has freed an entire segment
    0:12:39 of people to talk about it and have a different relationship with it. It’s one of the most
    0:12:45 entertaining parts of social is what’s happening in crypto. Again, the concept of crypto versus
    0:12:49 concept of money created a psychological shift in some people that then made the norms around
    0:12:50 it much different.
    0:12:54 So, you’re saying there are these subgroups, little niche categories, but it’s difficult
    0:12:57 to build a business around them until they reach that tipping point?
    0:13:01 I actually think you can build great businesses around some of these subcultures. There’s
    0:13:04 a lot of these quote-unquote niche, but they can be massive niches, right? Like Wall Street
    0:13:06 Bets has like 800,000 members.
    0:13:10 People always want to talk about how they’re making money. It’s having debt that’s always
    0:13:15 been private. So, the hardest problem in terms of social and money is having people talk
    0:13:20 about their debt, which is why people don’t want to have a relationship with their lender
    0:13:23 or talk in too much detail about certainly their credit card debt because they feel bad
    0:13:28 about it. They feel like it reflects poorly on them. Now, it’s just checking Insta right
    0:13:35 now and there’s 675,000 posts for #debtfreejourney. This has become a public conversation and a
    0:13:39 lot of it is happening on Instagram and I think that’s the hardest problem, the hardest
    0:13:43 segment to actually unlock. So, I actually think we’re pretty far ahead right now.
    0:13:47 Well, and to your point, Wall Street Bets is not just about, “I made a bunch of money.
    0:13:50 It’s also people posting, “Shit, I just lost a bunch of money.”
    0:13:54 Though, the subtext is, “Look at all the swagger I’ve got. I can lose all this money and it’s
    0:13:55 all good.”
    0:13:56 Yeah.
    0:13:57 Not always.
    0:14:03 Fair. Where this gets a lot more interesting is looking beyond social media and social
    0:14:08 networks and starting to talk about how this stuff drives an emergence that are products
    0:14:12 and how products are designed. Lauren and I both talked about this, which is the concept
    0:14:17 that as a product, you can create value in a functional way, which is, “Hey, my credit
    0:14:23 score was X and now it’s X plus Y.” You can create value in a cognitive way, which is,
    0:14:27 “Hey, I now better understand my credit score,” or you can create value in an emotional way,
    0:14:32 which is, “I feel better about my credit score and my financial situation.” Historically,
    0:14:36 most products have been designed with a complete focus on the functional and now we’re seeing
    0:14:40 the next generation of not just fintech but consumer products think more about cognitive
    0:14:41 and emotional.
    0:14:46 There’s also more offline examples than we’re all typically aware of. So, one I learned
    0:14:52 about over the last few years is called RASCAS, which is Rotating Savings and Credit Associations,
    0:14:56 which are these offline communities that are managed in mostly immigrant communities managed
    0:15:01 by an individual where everyone contributes, let’s say, $1,000 a month. And then each month,
    0:15:06 if there are 10 members, one member receives $10,000. And typically, these are folks in
    0:15:11 your community. You might meet them at church and it’s really hard to save $10,000. It’s
    0:15:15 a lot easier to contribute $1,000 a month. And then when you receive the lump sum, there’s
    0:15:20 always some big thing you want to do with the $10,000. There’s tons of examples of these
    0:15:25 micro communities has not yet successfully been brought online. So, not everything is
    0:15:29 sort of starting from zero when it comes to digital products.
    0:15:33 And those ones are interesting because there’s a different iteration of those in every single
    0:15:37 culture and every single country. And it is this robust offline behavior. And the question
    0:15:42 is how do you bring it online and how do you bring it online in a way that is culturally
    0:15:47 specific enough that it reflects the norms of that culture but also in a way that’s scalable?
    0:15:52 So there’s the example of Rosca’s in a lot of communities all over the world. And then
    0:15:57 I think if you look at the flip of that, what’s the extreme San Francisco version, it’s a
    0:16:01 lot of people here do things like invest in restaurants. Why would you ever invest in
    0:16:05 a restaurant? You’re probably not going to get your money back. There’s no liquidity.
    0:16:09 At best, it’s sort of like cool to tell your friends maybe that you’re an investor there.
    0:16:12 Maybe you skip a sort of reservation. It goes to emotional versus transactional.
    0:16:13 Totally.
    0:16:15 It’s not a transactional piece. It’s the emotion of the finance.
    0:16:21 Exactly. But the proof point of actually investing in something versus just frequenting something
    0:16:26 is very different. People want to participate. They want to express these preferences and
    0:16:27 money is the strongest way to do so.
    0:16:31 Well, and another example of something that’s inherently social. You’re investing in something
    0:16:34 that then has a built-in social network in the investment.
    0:16:38 There’s also this amazing trend around fractional ownership. So there’s a category of companies
    0:16:44 that includes Rally Road and Otis and Mythic. They will take some asset, be it a classic
    0:16:51 car, be it some culturally significant item, be it a magic card, be it a case of wine.
    0:16:53 There’s a different version of all of this. And they will take that asset and they’ll
    0:16:59 functionally securitize it. And then you, as a user, can purchase shares of that asset.
    0:17:03 And then in some cases, depending on the kind of investment that you make, you get certain
    0:17:07 levels of access or swag or other things that are associated with ownership.
    0:17:13 So on the one hand, you actually have a piece of equity, a share in something that is theoretically
    0:17:17 valuable because it’s actually a hard asset that has value. On the other side, you have
    0:17:23 the status of owner within this piece that is of value in a more emotional sense, which
    0:17:28 you’re investing in cultural pieces, which may or may not be a good financial investment
    0:17:32 but from emotional cognitive side can be really, really rewarding. So I think that’s another
    0:17:35 version where this idea of social plus fintech is taking off.
    0:17:38 I love this example. You know, we’ve talked about this internally as perhaps a future
    0:17:43 of museums and I think that vision is really interesting and it’s a much more emotional
    0:17:44 than rational.
    0:17:48 What’s the potential there? Are there areas where you see opportunity in some of these
    0:17:50 niche groups?
    0:17:54 I think social and finance is like the Holy Grail, right? The social version of most products
    0:17:59 is the best version of most products. Engagement is higher, retention is higher, customer acquisition
    0:18:03 costs go down. All these things that most consumer fintech companies struggle with are
    0:18:07 solved by building the social product. It’s the extent that you can get something that
    0:18:12 threads that needle between social and fintech. It’s amazing. It’s magical. It’s this incredible
    0:18:16 thing that happens when it actually happens. It’s really hard to do, but when it does happen,
    0:18:17 it’s phenomenal.
    0:18:21 I think the biggest opportunity comes from finding the emergent behavior within niche
    0:18:27 groups at the social level, at the community level, and then figuring out how fintech or
    0:18:32 transactional layers into or on top of that. The saying is every company is eventually going
    0:18:36 to become a fintech company, and I think that is probably the direction in which it goes
    0:18:41 and which you have weird social behavior that has some ability to layer transaction inside
    0:18:44 of it, and then that’s how social plus money takes off.
    0:18:49 In my mind, the most direct way to start seeing this play out is just having more fintech products
    0:18:54 address emotional needs as well as functional and cognitive needs. There’s some fintech products
    0:19:00 like Joy, an app where you rate every transaction on how it made you feel. The goal of the game,
    0:19:03 of course, is to only spend money on things that make you feel good, which is interesting.
    0:19:07 I think that’s a product that’s completely designed around a set of emotional needs with
    0:19:12 perhaps a set of functional outcomes as a happy side effect. I think there’s probably
    0:19:15 a middle ground where a lot of products that are focused on helping you buy your first
    0:19:21 home or reduce your debt or invest in stocks can actually start to design for these emotional
    0:19:25 needs when it comes to money. That’s how we actually start to see this achieve scale.
    0:19:29 Are there companies right now that you see making strides in that direction?
    0:19:33 I think an example of a company that’s really gotten this right is Credit Karma, and granted
    0:19:38 I was at Credit Karma. But if you look at the tone of the emails, if you look at the
    0:19:44 ads that are on TV, if you look at the way the product is positioned, it plays as much
    0:19:50 to curiosity and taking some of the heaviness out of credit. I think that’s been a really
    0:19:55 successful strategy for them. I think this is a company that’s gotten it right when it
    0:19:59 comes to how you talk to your customer about these otherwise really heavy things.
    0:20:03 As people share more, it becomes less intimidating.
    0:20:07 Or if you can see yourself relative to other people, that’s the other way that Credit Karma
    0:20:11 works. It’s like, I know where I stand relative to other people, and maybe it makes me stressed
    0:20:14 or maybe it makes me feel more comfortable, but at least there’s some level of transparency.
    0:20:19 Right. There’s some freedom in that transparency that perhaps is driving customer acquisition.
    0:20:24 That’s right. In terms of the products that have not worked, I think the product category
    0:20:29 that hasn’t really seen success is personal financial management tools. There’s two reasons.
    0:20:34 The first is that there’s a very small number of people who are super excited about budgeting
    0:20:38 and trying every budgeting app, which is why when a lot of these products launch, they
    0:20:42 get great growth in their first 18 to 24 months. You can get a couple of million users who
    0:20:47 are really engaged. That’s not actually representative of the wider market where most people hate
    0:20:51 budgeting. It’s not just because it’s a pain to keep a budget. It’s because it’s mostly
    0:20:57 bad news. I look at a lot of these PFM and budgeting apps like calorie counting apps.
    0:21:01 Just mostly makes you feel bad, and it’s easier to uninstall the app than it is to actually
    0:21:05 stick with the budget or the diet. I think that’s a great example of a product category
    0:21:10 that despite the fact that there’s real functional value there, it hasn’t taken off because it
    0:21:14 didn’t address the emotional challenge that the consumer is facing.
    0:21:19 I think another category that has not worked super well is ones that are designed to be
    0:21:24 social but only transactional. I think there’s been this long history of people trying to
    0:21:29 get people to be more public about what their portfolio is, and then other people can invest
    0:21:35 based off of that portfolio, and it benefits the portfolio manager who’s sharing it. That’s
    0:21:41 one where it is almost purely transactional relationship with purely financial incentives.
    0:21:44 I think there’s been a lot of attempts at that. As far as I’m aware, none of them have
    0:21:48 really taken off, but I think that’s another category where when you just stick within one
    0:21:53 kind of bucket just within the transactional side, it’s really hard to layer social into
    0:21:54 that.
    0:21:58 So if we agree that social meets Vintec is really hard to do, but I’ve also heard you
    0:22:03 both say it is the holy grail. Why is that? What makes it so powerful if we can get there?
    0:22:07 I think first of all, if you just look at it, the most narrow lens is just from a core
    0:22:13 business perspective. Stickiness, cross-out, acquisition, all of these things that are
    0:22:18 super hard problems for most Vintec companies become dramatically easier if there’s a strong
    0:22:24 social layer. So that’s the most narrow lens. And then I think the broadest lens is just
    0:22:30 ending this dynamic where we’re alone together. Everyone’s in a dark room feeling bad about
    0:22:34 their money with everyone else in that same dark room, and I think if you can turn the
    0:22:40 light on, then all of a sudden, it is an opportunity to uplift everyone a little bit and normalize
    0:22:44 the situation that folks are in. I think that with, especially we talked about both the
    0:22:50 good side of Insta, but Insta is also a very public place to talk about your spending,
    0:22:55 and I think that that drives a perverse set of expectations around what’s normal, and
    0:22:56 we should try to change that.
    0:23:00 Yes. There’s multiple levels to why social plus money is this holy grail. Another lens
    0:23:07 is it broadens the solution space within which, as a founder, you can operate because now you’re
    0:23:12 not just on the transactional level or you’re not just on the emotional and cognitive level,
    0:23:17 you’re now across all three. If you actually have financial or social plus Vintec or whatever
    0:23:23 it is, so you can now design things that have some combination of those three levers, which,
    0:23:26 if you’re competing against a purely transactional thing or you’re competing against a purely
    0:23:31 emotional thing, you now just have more factors that you can operate across. The flip side
    0:23:37 to that is it’s combinatorially more complicated to do, but if you do do it, you’re in a class
    0:23:38 of your own.
    0:23:40 Thank you for joining us on the A16Z podcast.
    0:23:41 Thanks, Lauren.
    0:23:42 Thanks, Darcy.
    0:23:43 Thanks, Anish.
    0:23:43 Cheers.
    0:23:53 [BLANK_AUDIO]

    The last financial crisis prompted many consumers to reassess their banking expectations—none more so than millennials and Gen-Z-ers. While revealing one’s financial information was once considered taboo, now consumers are more apt than ever to openly discuss money and debt on online platforms. It’s a trend that’s evident on both ends of the spectrum, whether that’s people divulging their crushing levels of debt on Twitter and Instagram (#debtfreejourney), bragging about their credit scores, or bemoaning their latest stock trades. And the repercussions extend far beyond social media. 

    In this conversation with fintech general partner Anish Acharya (a former product manager at Credit Karma), consumer tech partner D’Arcy Coolican (a social+ fintech founder himself), and host Lauren Murrow, we discuss why the “holy grail” of social plus fintech is both so challenging and, potentially, so rewarding. We cover which products and companies are taking advantage of it (some in rather novel ways), how it’s being driven by various subcultures online, and why this shift is happening now.  

  • Innovation Through Software Development and IT

    AI transcript
    0:00:05 Hi everyone, welcome to the A6NZ podcast, I’m Sonal.
    0:00:08 So one of the recurring themes we talk a lot about on this podcast is how software changes
    0:00:11 organizations and vice versa.
    0:00:16 More broadly, it’s really about how companies of all kinds innovate with the org structures
    0:00:18 and tools that they have.
    0:00:22 And today’s episode, a rerun of a very popular episode from a couple years ago, draws on
    0:00:28 actual research and data from one of the largest large-scale studies of software and organizational
    0:00:30 performance out there.
    0:00:34 Joining me in this conversation are two of the authors of the book Accelerate, the Science
    0:00:39 of Lean Software and DevOps by Nicole Forsgren, Jez Humble, and Jean Kim.
    0:00:43 We have the first two authors, so Nicole, who did her PhD research trying to answer
    0:00:48 the lucid, eternal questions around how to measure software performance in orgs, especially
    0:00:52 given past debates, around does IT matter?
    0:00:57 She was the co-founder and CEO of Dora, which put out the annual State of DevOps report.
    0:01:02 Dora was acquired by Google Cloud a little over a year ago, and she will soon be joining
    0:01:05 GitHub as VP of Research and Strategy.
    0:01:10 And then we also have Jez Humble, who was CTO at Dora, is currently in developer relations
    0:01:17 at Google Cloud and is also the co-author of the books The DevOps Handbook, Lean Enterprise,
    0:01:18 and Continuous Delivery.
    0:01:23 In the conversation that follows, Nicole and Jez share their findings about high-performing
    0:01:27 companies, even those that may not think they’re tech companies, and answer my questions about
    0:01:32 whether there’s an ideal org type for this kind of innovation, whether it’s the size
    0:01:36 of the organization, the software architecture they use, their culture or people, and where
    0:01:39 the role of software and IT lives within that.
    0:01:44 But first, we begin by talking briefly about the history of DevOps and where that fits
    0:01:48 in the broader landscape of related software movements.
    0:01:50 So I started as a software engineer at IBM.
    0:01:54 I did hardware and software performance, and then I took a bit of a detour into academia
    0:01:59 because I wanted to understand how to really measure and look at performance that would
    0:02:04 be generalizable to several teams in predictable ways and in predictive ways.
    0:02:10 And so I was looking at and investigating how to develop and deliver software in ways
    0:02:15 that were impactful to individuals, teams, and organizations.
    0:02:20 And then I pivoted back into industry because I realized this movement had gained so much
    0:02:26 momentum and so much traction, and industry was desperate to really understand what types
    0:02:30 of things are really driving performance outcomes and excellence.
    0:02:32 And what do you mean by this movement?
    0:02:38 This movement that now we call DevOps, so the ability to leverage software to deliver
    0:02:44 value to customers, to organizations, to stakeholders.
    0:02:47 And I think from a historical point of view, the best way to think about DevOps, it’s
    0:02:53 a bunch of people who had to solve this problem of how do we build large distributed systems
    0:02:59 that were secure and scalable and be able to change them really rapidly and evolve them.
    0:03:02 And no one had had that problem before, certainly at the scale of companies like Amazon and
    0:03:03 Google.
    0:03:07 And that really is where the DevOps movement came from, trying to solve that problem.
    0:03:11 And you can make an analogy to what Agile was about since the kind of software crisis
    0:03:17 of the 1960s and people trying to build these defense systems at large scale, the invention
    0:03:24 of software engineering as a field, Margaret Hamilton, her work at MIT on the Apollo program.
    0:03:28 What happened in the decades after that was everything became kind of encased in concrete
    0:03:33 in these very complex processes, this is how you develop software.
    0:03:36 And Agile was kind of a reaction to that, saying we can develop software much more
    0:03:40 quickly with much smaller teams in a much more lightweight way.
    0:03:43 So we didn’t call it DevOps back then, but it’s also more Agile.
    0:03:45 Can you guys break down the taxonomy for a moment?
    0:03:48 Because when I think of DevOps, I think of it in the context of the containerization
    0:03:51 of code and virtualization.
    0:03:56 I think of it in the context of microservices and being able to do modular teams around
    0:03:57 different things.
    0:03:59 There’s an organizational element, there’s a software element, there’s an infrastructure
    0:04:03 component, like paint the big picture for me of those building blocks and how they all
    0:04:04 kind of fit together.
    0:04:07 Well, I can give you a very personal story, which was my first show after college was
    0:04:12 in 2000 in London, working at a startup where I was one of two technical people in the startup.
    0:04:17 And I would deploy to production by FTP and code from my laptop directly into production.
    0:04:21 And if I wanted to roll back, I’d say, “Hey, Johnny, can you FTP your copy of this file
    0:04:22 to production?”
    0:04:23 And that was our rollback process.
    0:04:27 And then I went to work in consultancy where we were on these huge teams and deploying
    0:04:30 to production, there was a whole team with a Gantt chart which put together the plan
    0:04:31 to deploy to production.
    0:04:32 And I’m like, this is crazy.
    0:04:36 Unfortunately, I was working with a bunch of other people who also thought it was crazy.
    0:04:40 And then we came up with these ideas around deployment automation and scripting and stuff
    0:04:41 like that.
    0:04:44 And suddenly we saw the same ideas had popped up everywhere, basically.
    0:04:48 I mean, it’s realising that if you’re working in a large complex organisation, Agile’s going
    0:04:54 to hit a brick wall because unlike the things we were building in the ’60s, product development
    0:04:56 means that things are changing and evolving all the time.
    0:04:58 So it’s not good enough to get to production the first time.
    0:05:00 You’ve got to be able to keep getting there on and on.
    0:05:01 And that really is where DevOps comes in.
    0:05:05 It’s like, well, Agile, we’ve got a way to build and evolve products, but how do we keep
    0:05:10 deploying to production and running the systems in production in a stable, reliable way, particularly
    0:05:12 in the distributed context?
    0:05:16 So if I phrase it another way, sometimes there’s a joke that says day one is short and day
    0:05:17 two is long.
    0:05:18 What does that mean?
    0:05:19 Right.
    0:05:20 So day one is when we create all these–
    0:05:21 That’s by the way sad that you have to explain the joke to me.
    0:05:22 No, it’s–
    0:05:26 No, which is great, though, because so day one is when we create all of these systems.
    0:05:28 And day two is when we deploy to production.
    0:05:33 We have to deploy and maintain forever and ever and ever and ever.
    0:05:35 So day two is an infinite day.
    0:05:36 Right, exactly.
    0:05:37 Yeah.
    0:05:38 First successful product.
    0:05:39 Hopefully.
    0:05:41 We hope that day two is really, really long.
    0:05:45 And we’re fond of saying Agile doesn’t scale.
    0:05:48 And sometimes I’ll say this, and people shoot laser beams out of their eyes.
    0:05:50 But when we think about it, Agile was meant for development.
    0:05:53 Just like Jez said, it speeds up development.
    0:05:58 But then you have to hand it over and especially infrastructure and IT operations.
    0:05:59 What happens when we get there?
    0:06:02 So DevOps was sort of born out of this movement.
    0:06:06 And it was originally called Agile System Administration.
    0:06:10 And so then DevOps sort of came out of development and operations.
    0:06:14 And it’s not just DevOps, but if we think about it, that’s sort of the bookends of
    0:06:15 this entire process.
    0:06:17 Well, it’s actually like day one and day two combined into one phrase.
    0:06:19 Day one and day two.
    0:06:23 The way I think about this is I remember the stories of Microsoft in the early days and
    0:06:29 the waterfall cascading model of development, Leslie Lamport once wrote a piece for me about
    0:06:33 why software should be developed like houses because you need a blueprint.
    0:06:37 And I’m not a software developer, but it felt like a very kind of old way of looking at
    0:06:38 the world of code.
    0:06:40 I hate that metaphor.
    0:06:41 Tell me why.
    0:06:44 If the thing you’re building has well understood characteristics, it makes sense.
    0:06:47 So if you’re building a trust bridge, for example, there’s well-known understood models
    0:06:51 of building trust bridges, you plug the parameters into the model and then you get a trust bridge
    0:06:52 and it stays up.
    0:06:55 Have you been to Sagrada Familia in Barcelona?
    0:06:56 Oh, I love Gaudi.
    0:06:57 Okay.
    0:07:00 So if you go into the crypt of the Sagrada Familia, you’ll see his workshop and there’s
    0:07:05 a picture, in fact, a model that he built of the Sagrada Familia, but upside down with
    0:07:07 the weight simulating the stresses.
    0:07:10 And so he would build all these prototypes and small prototypes because he was fundamentally
    0:07:12 designing a new way of building.
    0:07:17 All Gaudi’s designs were hyperbolic curves and parabolic curves and no one had used that
    0:07:18 before.
    0:07:19 Things that had never been pressure tested.
    0:07:20 Right.
    0:07:21 Literally.
    0:07:22 In that case.
    0:07:23 Exactly.
    0:07:24 He didn’t want them to fall down.
    0:07:25 So he built all these prototypes and did all this stuff.
    0:07:29 He built his blueprint as he went by building and trying it out, which is a very rapid prototyping
    0:07:30 kind of model.
    0:07:31 Absolutely.
    0:07:34 So in the situation where the thing you’re building has known characteristics and it’s
    0:07:38 been done before, yeah, sure, we can take a very phased approach to it.
    0:07:42 And, you know, for designing these kind of protocols that have to work in a distributed
    0:07:46 context and you can actually do formal proofs of them, again, that makes sense.
    0:07:51 But when we’re building products and services where particularly we don’t know what customers
    0:07:55 actually want and what users actually want, it doesn’t make sense to do that because you’ll
    0:07:57 build something that no one wants.
    0:07:58 You can’t predict.
    0:08:00 And we’re particularly bad at that, by the way.
    0:08:05 Even companies like Microsoft, where they are very good at understanding what their
    0:08:09 customer base looks like, they have a very mature product line.
    0:08:15 Ronnie Cahave has done studies there and only about one-third of the well-designed features
    0:08:16 deliver value.
    0:08:18 That’s actually a really important point.
    0:08:22 The mere question of does this work is something that people really clearly don’t pause to
    0:08:26 ask, but I do have a question for you guys to push back, which is, is this a little bit
    0:08:27 of the cult?
    0:08:31 Oh, my God, it’s like so developer-centric, let’s be agile, let’s do it fast, our way,
    0:08:35 you know, two pizzas, that’s the ideal size of a software team and, you know, I’m not
    0:08:36 trying to mock it.
    0:08:41 I’m just saying that isn’t there an element of actual practical realities like technical
    0:08:46 debt and accruing a mess underneath all your code and a system that you may be there for
    0:08:49 two or three years and you can go after the next startup, but okay, someone else has to
    0:08:51 clean up your mess.
    0:08:53 Tell me about how this fits into that big picture.
    0:08:55 This is what enables all of that.
    0:08:56 Oh, right.
    0:08:57 Interesting.
    0:08:59 So it’s not actually just creating a problem because that’s how I’m kind of hearing it.
    0:09:00 No, absolutely.
    0:09:05 So you still need development, you still need test, you still need QA, you still need operations,
    0:09:08 you still need to deal with technical debt, you still need to deal with re-architecting
    0:09:12 really difficult large monolithic code bases.
    0:09:17 What this enables you to do is to find the problems, address them quickly, move forward.
    0:09:22 I think that the problem that a lot of people have is that we’re so used to couching these
    0:09:26 things as trade-offs and as dichotomies, the idea that if you’re going to move fast, you’re
    0:09:27 going to break things.
    0:09:32 The one thing which I always say is, if you take one thing away from DevOps is this, high-performing
    0:09:34 companies don’t make those trade-offs.
    0:09:36 They’re not going fast and breaking things.
    0:09:40 They’re going fast and making more stable, more high-quality systems, and this is one
    0:09:44 of the key results in the book, in our research, is this fact that high-performers do better
    0:09:49 at everything because the capabilities that enable high-performance in one field, if done
    0:09:51 right, enable it in other fields.
    0:09:55 If you’re using version control for software, you should also be using version control for
    0:09:56 your production infrastructure.
    0:10:00 If there’s a problem in production, we can reproduce the state of the production environment
    0:10:05 in a disaster recovery scenario, again in a predictable way that’s repeatable.
    0:10:07 I think it’s important to point out that this is something that happened in manufacturing
    0:10:08 as well.
    0:10:09 Give it to me.
    0:10:13 I love when people talk about software as drawn from hardware analogies as my favorite
    0:10:14 type of metaphor.
    0:10:20 Okay, so Toyota didn’t win by making shitty cars faster, they won by making higher-quality
    0:10:22 cars faster and having shorter time to market.
    0:10:25 The lean manufacturing method, which by the way also spawned lean startup thinking and
    0:10:26 everything else connected to it.
    0:10:30 And DevOps pulls very strongly from lean methodologies.
    0:10:34 So you guys are probably the only people to have actually done a large-scale study of
    0:10:36 organizations adopting DevOps.
    0:10:38 What is your research and what did you find?
    0:10:39 Sure.
    0:10:44 My research really is the largest investigation of DevOps practices around the world.
    0:10:48 We have over 23,000 data points, all industries.
    0:10:49 Give me like a sampling, like what are the range of industries?
    0:10:56 So I’ve got entertainment, I’ve got finance, I have healthcare and pharma, I have technology.
    0:10:57 Government.
    0:10:58 Government, education.
    0:11:00 You basically have every vertical.
    0:11:01 And then when you tell you around the world.
    0:11:07 So we’re primarily in North America, we’re in Amia, we have India, we have a small sample
    0:11:08 in Africa.
    0:11:09 Right.
    0:11:13 And we break down like the survey methodology questions that people have in the ethnographic
    0:11:17 world, the way we would approach it is that you can never trust what people say they do.
    0:11:19 You have to watch what they do.
    0:11:23 However, it is absolutely true, and especially in a more scalable sense, that there are really
    0:11:25 smart surveys that give you a shit ton of useful data.
    0:11:26 Yes.
    0:11:30 And part two of the book covers this in almost excruciating detail.
    0:11:31 We like knowing methodologies.
    0:11:32 Yes.
    0:11:33 So it’s nice to share that.
    0:11:37 Well, and it’s interesting because Jez talked about in his overview of Agile and how it changes
    0:11:41 so quickly and we don’t have a really good definition, but that does is it makes it difficult
    0:11:42 to measure.
    0:11:43 Right.
    0:11:49 And so what we do is we’ve defined core constructs, core capabilities, so that we can then measure
    0:11:50 them.
    0:11:57 We go back to core ideas around things like automation, process, measurement, lean principles.
    0:12:02 And then I’ll get that pilot set of data and I’ll run preliminary statistics to test for
    0:12:06 discriminant validity, convergent validity, composite reliability.
    0:12:09 Make sure that it’s not testing what it’s not supposed to test.
    0:12:12 It is testing what it is supposed to test.
    0:12:15 Everyone is reading it consistently the same way that I think it’s testing.
    0:12:20 I even run checks to make sure that I’m not inadvertently inserting bias or collecting
    0:12:23 bias just because I’m getting all of my data from surveys.
    0:12:25 Sounds pretty damn robust.
    0:12:28 So tell me then what were the big findings?
    0:12:30 That’s a huge question, but give me the hit list.
    0:12:31 Well, okay.
    0:12:35 So let’s start with one thing that Jess already talked about, speed and stability go together.
    0:12:39 This is where he was talking about there not being necessarily a false dichotomy and that’s
    0:12:41 one of your findings that you can actually accomplish both.
    0:12:42 Yeah.
    0:12:43 And it’s worth talking about how we measure those things as well.
    0:12:48 So we measure speed or tempo as we call it in the book or sometimes people call it throughput
    0:12:49 as well.
    0:12:53 Which is a nice full circle manufacturing idea, like the semiconductor circuit throughput.
    0:12:54 Yeah, absolutely.
    0:12:56 I love hardware analogies for software, I told you.
    0:12:57 A lot of it comes from lean.
    0:13:01 So lead time, obviously one of the classic lean manufacturing measures we use.
    0:13:02 How long does it take?
    0:13:06 You look at the lead time from checking into version control to release into production.
    0:13:09 So that part of the value stream because that’s more focused on the DevOps end of things.
    0:13:11 And it’s highly predictable.
    0:13:12 The other one is release frequency.
    0:13:13 So how often do you do it?
    0:13:17 And then we’ve got two stability metrics and one of them is time to restore.
    0:13:21 So in the event that you have some kind of outage or some degradation in performance in
    0:13:24 production, how long does it take you to restore service?
    0:13:27 For a long time we focused on not letting things break.
    0:13:30 And I think one of the changes, paradigm shifts we’ve seen in the industry, particularly
    0:13:32 in DevOps, is moving away from that.
    0:13:36 We accept that failure is inevitable because we’re building complex systems.
    0:13:40 So not how do we prevent failure, but when failure inevitably occurs, how quickly can
    0:13:41 we detect and fix it?
    0:13:42 MTBF, right?
    0:13:43 Mean time between failures.
    0:13:48 If you only go down once a year, but you’re down for three days and it’s on Black Friday.
    0:13:52 But if you’re down very small, low blast, very, very small blast radius and you can come
    0:13:57 back almost immediately and your customers almost don’t notice.
    0:13:58 That’s fine.
    0:14:00 The other piece around stability is change fail, right?
    0:14:03 When you push a change into production, what percentage of the time do you have to fix
    0:14:04 it?
    0:14:05 Because something went wrong.
    0:14:07 By the way, what does that tell you if you have a change fail?
    0:14:10 So in the lean kind of discipline, this is called percent complete and accurate.
    0:14:12 And it’s a measure of a quality of your process.
    0:14:17 So in a high quality process, when I do something for Nicole, Nicole can use it rather than
    0:14:21 sending it back to me and say, “Hey, there’s a problem with this.”
    0:14:24 And in this particular case, what percentage of the time when I deploy something to production
    0:14:27 is there a problem because I didn’t test it adequately.
    0:14:29 My testing environment wasn’t production like enough.
    0:14:31 Those are the measures for finding this.
    0:14:36 But the big finding is that you can have speed and stability together through DevOps.
    0:14:38 Is that what I’m hearing?
    0:14:39 Yes, yes.
    0:14:40 High performers get it all.
    0:14:42 Low performers kind of suck at all of it.
    0:14:43 Medium performers hang out in the middle.
    0:14:46 I’m not seeing trade-offs four years in a row.
    0:14:50 So anyone who’s thinking, “Oh, I can be more stable if I slow down,” I don’t see it.
    0:14:54 It actually breaks a very commonly held kind of urban legend around how people believe
    0:14:55 these things operate.
    0:14:58 So tell me, are there any other sort of findings like that?
    0:14:59 Because that’s very counterintuitive.
    0:15:01 Okay, so this one’s kind of fun.
    0:15:07 One is that this ability to develop and deliver software with speed and stability drives organizational
    0:15:08 performance.
    0:15:09 Now, here’s the thing.
    0:15:11 I was about to say, that’s a very obvious thing to say.
    0:15:13 So it seems obvious, right?
    0:15:17 Developing and delivering software with speed and stability drives things like profitability,
    0:15:19 productivity, market share.
    0:15:26 Okay, except if we go back to Harvard Business Review 2003, there’s a paper titled, “IT Doesn’t
    0:15:27 Matter.”
    0:15:32 We have decades of research, I want to say at least 30 or 40 years of research showing
    0:15:37 the technology does not drive organizational performance.
    0:15:38 It doesn’t drive ROI.
    0:15:43 And we are now starting to find other studies and other research that backs this up.
    0:15:48 Eric Brinniol sent out of MIT, James Best sent out of Boston University, 2017.
    0:15:50 Did you say James Bessen?
    0:15:51 Yeah.
    0:15:52 Oh, I used to edit him, too.
    0:15:54 Yeah, it’s fantastic.
    0:15:56 Here’s why it’s different.
    0:16:01 Because before, right in like the 80s and the 90s, we did this thing where like, you’d
    0:16:03 buy the tech and you’d plug it in and you’d walk away.
    0:16:07 It was on-prem sales model where you like deliver and leave as opposed to like software
    0:16:09 as a service and the other ways that things happen.
    0:16:11 And people would complain if you tried to upgrade it too often.
    0:16:12 Oh, right.
    0:16:17 The key is that everyone else can also buy the thing and plug it in and walk away.
    0:16:22 How is that driving value or differentiation for a company?
    0:16:27 If I just buy a laptop to help me do something faster, everyone else can buy a laptop to do
    0:16:29 the same thing faster.
    0:16:34 That doesn’t help me deliver value to my customers or to the market.
    0:16:36 It’s a point of parity, not a point of distinction.
    0:16:37 Right.
    0:16:40 And you’re saying that point of distinction comes from how you tie together that technology
    0:16:43 process and culture through DevOps.
    0:16:44 Right.
    0:16:46 And that it can provide a competitive advantage to your business.
    0:16:50 If you’re buying something that everyone else also has access to, then it’s no longer a
    0:16:51 differentiator.
    0:16:54 But if you have an in-house capability and those people are finding ways to drive your
    0:16:57 business, I mean, this is the classic Amazon model.
    0:17:01 They’re running hundreds of experiments in production at any one time to improve the
    0:17:02 product.
    0:17:05 And that’s not something that anyone else can copy, that’s why Amazon keeps winning.
    0:17:08 So what people are doing is copying the capability instead.
    0:17:09 And that’s what we’re talking about.
    0:17:10 How do you build that capability?
    0:17:14 The most fascinating thing to me about all this is honestly not the technology per se,
    0:17:17 but the organizational change part of it and the organizations themselves.
    0:17:22 So of all the people you studied, is there an ideal organizational makeup that is ideal
    0:17:23 for DevOps?
    0:17:27 Or is it one of these magical formulas that has this ability to turn a big company into
    0:17:31 a startup and a small company into, because that’s actually the real question.
    0:17:34 From what I’ve seen, there might be two ideals.
    0:17:39 The nice, happy answer is the ideal organization is the one that wants to change.
    0:17:44 That’s, I mean, given this huge n equals 23,000 dataset, is it not tied to a particular profile
    0:17:45 of a size of company?
    0:17:47 They’re both shaking their head just for the listeners.
    0:17:51 I see high performers among large companies.
    0:17:52 I see high performers in small companies.
    0:17:55 I see low performers in small companies.
    0:17:57 I see low performers in highly regulated companies.
    0:18:00 I see low performers in not regulated companies.
    0:18:03 So tell me the answer you’re not supposed to say.
    0:18:11 So that answer is it tends to be companies that are like, oh shit, and they’re two profiles.
    0:18:16 Number one, they’re like way behind, and oh shit, and they have some kind of funds.
    0:18:25 Or they are like this lovely, wonderful bastion of like they’re these really innovative, high-performing
    0:18:29 companies, but they still realize they’re a handful of like two or three companies ahead
    0:18:31 of them, and they don’t want to be number two.
    0:18:32 They are going to be number one.
    0:18:33 So those are sort of the ideal.
    0:18:35 I mean, just like anthropomorphize it a little bit.
    0:18:41 It’s like the 35 to 40 year old who suddenly discovers you might be pre-diabetic, so you
    0:18:43 better do something about it now before it’s too late.
    0:18:47 But it’s not too late because you’re not so old where you’re about to reach sort of
    0:18:50 the end of a possibility to change that runway.
    0:18:54 And then there’s this person who’s sort of kind of already like in the game running in
    0:18:57 the race and they might be two or three, but they want to be like number one.
    0:19:02 And I think to extend your metaphor, the companies that do well are the companies that never got
    0:19:05 diabetic in the first place because they always just ate healthily.
    0:19:07 They were already glucose monitoring.
    0:19:10 They had continuous glucose monitors on, which is like DevOps actually.
    0:19:11 They were always athletes.
    0:19:12 Right.
    0:19:15 You know, diets are terrible because at some point you have to stop the diet.
    0:19:18 And it has to start and start and stop as opposed to a way of life is what you’re saying.
    0:19:19 Right, exactly.
    0:19:24 So if you just always eat healthily and never eat too much or very rarely eat too much and
    0:19:27 do a bit of exercise every day, you never get to the stage like, oh my God, now I can
    0:19:29 only eat tofu.
    0:19:39 So like my loving professerness, nurture Nicole also has one more profile that like I love
    0:19:42 and I worry about them like mother hen.
    0:19:47 And it’s the companies that I talk to and they come to me and they’re struggling and
    0:19:52 I haven’t decided if they want to change, but they’re like, so we need to do this transformation
    0:19:53 and we’re going to do the transformation.
    0:19:57 And it’s either because they want to or when they’ve been told that they need to.
    0:20:01 And then they will insert this thing where they say, but I’m not a technology company.
    0:20:08 I’m like, but we just had this 20 minute conversation about how you’re leveraging technology to drive
    0:20:13 value to customers or to drive this massive process that you do.
    0:20:15 And then they say, but I’m not a technology company.
    0:20:19 I could almost see why they had that in their head because they were a natural resources
    0:20:20 company.
    0:20:23 But there was another one where they were a finance company.
    0:20:27 I mean, an extension of software eats the world is really every company is a technology
    0:20:28 company.
    0:20:32 It’s fascinating to me that that third type exists, but it is a sign of this legacy world
    0:20:38 moving into and I worry about them also, at least for me personally, you know, I lived
    0:20:42 through this like mass extinction of several firms and I don’t want it to happen again.
    0:20:46 And I worry about so many companies that keep insisting they’re not technology companies.
    0:20:49 And I’m like, oh, honey child, you’re a tech company.
    0:20:51 You know, one of the gaps in our data is actually China.
    0:20:55 And I think big China is a really interesting example because they didn’t go through the
    0:20:58 whole, you know, IT doesn’t matter phase.
    0:21:02 They’re jumping straight from no technology to Alibaba and Tencent, right?
    0:21:07 I think US companies should be scared because the moment Tencent and Alibaba already made
    0:21:12 moving into other developing markets and they’re going to be incredibly competitive because
    0:21:13 it’s just built into their DNA.
    0:21:16 So the other fascinating thing to me is that you essentially were able to measure performance
    0:21:20 of software and clearly productivity.
    0:21:22 Is there any more insights on the productivity side?
    0:21:23 Yes.
    0:21:24 Yes.
    0:21:25 I want to go.
    0:21:26 This is his favorite ramp.
    0:21:27 Jumping around and like waving his hand.
    0:21:31 So tell us the reason the manufacturing metaphor breaks down is because in manufacturing you
    0:21:32 have inventory.
    0:21:33 Yes.
    0:21:36 We do not have inventory in the same way in software.
    0:21:39 In a factory, like the first thing your lean consultant is going to do, walking into the
    0:21:42 factory is point to the piles of thing everywhere.
    0:21:47 But I think if you walk into an office where there’s developers, where’s the inventory?
    0:21:50 By the way, that’s what makes talking about this to executives so difficult.
    0:21:51 They can’t see the process.
    0:21:56 Well, it’s a hard question to answer because is the inventory the code that’s being written?
    0:22:00 And people actually have done that and said, “Well, listen, lines of code are an accounting
    0:22:04 measure and we’re going to capture that as, you know, capital.”
    0:22:05 That’s insane.
    0:22:08 It’s like an invitation to write crappy, unnecessarily long code.
    0:22:09 That’s exactly what happens.
    0:22:11 It’s like the olden days are getting paid for a book by how long it is and it’s like
    0:22:14 actually really boring when you can actually write it in like one third of the length.
    0:22:15 Let’s write it in German.
    0:22:16 Right, you know.
    0:22:17 I’m thinking of Charles Dickens.
    0:22:19 In general, you know, you prefer people to write short programs because they’re easier
    0:22:21 to maintain and so forth.
    0:22:23 But lines of code have all these drawbacks.
    0:22:25 We can’t use them as a measure of productivity.
    0:22:27 So if you can’t measure lines of code, what can you measure?
    0:22:30 Because I really want an answer like, how do you measure productivity?
    0:22:31 So velocity is the other classic example.
    0:22:38 Agile, there’s this concept of velocity, which is the number of story points a team manages
    0:22:41 to complete in an iteration.
    0:22:47 So before the start of an iteration in many agile, particularly scrum-based processes,
    0:22:48 you’ve got all this work to do.
    0:22:50 You’re like, “We need to build these five features.
    0:22:51 How long will this feature take?”
    0:22:54 And the developers fight over it and they’re like, “Oh, it’s five points.”
    0:22:57 And then this one’s going to take three points, this one’s going to take two points.
    0:23:00 And so you have a list of all these features and you don’t get through all of them.
    0:23:03 At the end of the iteration, the customer signs off, “Well, I’m accepting this one.
    0:23:04 This one’s fine.
    0:23:05 This one’s fine.
    0:23:06 This one’s a hot mess.
    0:23:07 Go back and do it again.”
    0:23:08 Whatever.
    0:23:09 The number of points you complete in the iteration is the velocity.
    0:23:12 So it’s like the speed at which you’re able to deliver those features.
    0:23:16 So a lot of people treat it like that, but actually, that’s not really what it’s about.
    0:23:20 It’s a relative measure of effort and it’s for capacity planning purposes.
    0:23:23 So basically, for the next iteration, we’ll only commit to completing the same velocity
    0:23:24 that we finished last time.
    0:23:27 So it’s relative and it’s team dependent.
    0:23:30 And so what a lot of people do is say they start comparing velocities across teams.
    0:23:34 Then what happens is, a lot of work, you need to collaborate between teams.
    0:23:38 But hey, if I’m going to help you with your story, that means I’m not going to get my
    0:23:42 story points and you’re going to get your story points, right, people can game it as
    0:23:43 well.
    0:23:45 You should never use story points as a productivity measure.
    0:23:48 So lines of code doesn’t work, velocity doesn’t work, what works?
    0:23:53 So this is why we like, two things in particular, one thing that it’s a global measure.
    0:23:57 And secondly, that it’s not just one thing, it mixes two things together, which might
    0:23:59 normally be intention.
    0:24:03 And so this is why we went for our measure of performance.
    0:24:11 So measuring lead time, release frequency, and then time to restore and change fail rate.
    0:24:15 Lead time is really interesting because lead time is on the way to production, right?
    0:24:17 So all the teams have to collaborate.
    0:24:21 It’s not something where I can go really fast in my velocity, but nothing ever gets delivered
    0:24:22 to the customer.
    0:24:23 It doesn’t count in lead time.
    0:24:24 So it’s a global measure.
    0:24:27 It takes care of that problem of the incentive alignment around the competitive dynamic.
    0:24:30 Also, it’s an outcome.
    0:24:31 It’s not an output.
    0:24:33 There’s a guy called Jeff Patton.
    0:24:36 He’s a really smart thinker in the kind of lead and agile space.
    0:24:43 He says, minimize output, maximize outcomes, which I think is simple but brilliant.
    0:24:45 It’s so simple because it just shifts the words to impact.
    0:24:49 And even we don’t get all the way there because we’re not yet measuring, did the features
    0:24:51 deliver the expected value to the organization or the customers?
    0:24:58 Well, we do get there because we focus on speed and stability, which then deliver the
    0:25:02 outcome to the organization, profitability, productivity, market share.
    0:25:07 But the second half of this, which I am also hearing is, did it meet your expectations?
    0:25:11 Did it perform to the level that you wanted it to?
    0:25:13 Did it match what you asked for?
    0:25:18 Or even if it wasn’t something you specified that you desired or needed, that seems like
    0:25:19 a slightly open question.
    0:25:20 So we did actually measure that.
    0:25:24 We looked at non-profit organizations and these were exactly the questions we measured.
    0:25:29 We asked people, did the software meet, I can’t remember what the exact questions were.
    0:25:33 Effectiveness, efficiency, customer satisfaction, delivery, mission goals.
    0:25:35 How fascinating that you do it non-profits because that is a larger move in the non-profit
    0:25:38 measurement space to try to measure impact.
    0:25:43 But we captured it everywhere because even profit seeking firms still have these goals.
    0:25:47 In fact, as we know from research, companies that don’t have a mission other than making
    0:25:49 money do less well than the ones that do.
    0:25:54 I think, again, what the data shows is that companies that do well on the performance measures
    0:25:58 we talked about outperform their low performing peers by a factor of two.
    0:26:02 A hypothesis is what we’re doing when we create these high performing organizations in terms
    0:26:06 of speed and stability is we’re creating feedback loops.
    0:26:11 What it allows us to do is build a thin slice, a prototype of a feature, get feedback through
    0:26:16 some UX mechanism, whether that’s showing people the prototype and getting their feedback,
    0:26:19 whether it’s running A/B tests or multivariate tests in production.
    0:26:23 It’s what creates these feedback loops that allow you to shift direction very fast.
    0:26:25 I mean, that is the heart of Lean Startup.
    0:26:29 It’s the heart of anything you’re putting out into the world is you have to kind of
    0:26:30 bring it full circle.
    0:26:33 It is a secret of success to Amazon, as you cited earlier.
    0:26:35 I would distill it to just that.
    0:26:37 I think I heard Jeff Bezos say the best line.
    0:26:40 It was at the Internet Association dinner in DC last year where he came and asked me
    0:26:41 about an innovation.
    0:26:44 He’s like, to him, an innovation is something that people actually use.
    0:26:47 And that’s what I love about the feedback loop thing, is it actually reinforces that
    0:26:49 mindset of that’s what innovation is.
    0:26:50 Right.
    0:26:54 So to sum up, the way you can frame this is DevOps is that technological capability
    0:26:59 that underpins your ability to practice Lean Startup and all these very rapid iterative
    0:27:00 processes.
    0:27:02 So I have a couple of questions then.
    0:27:07 So one is going back to this original taxonomy question, and you guys described that there
    0:27:09 isn’t necessarily an ideal organizational type.
    0:27:11 Which by the way, should be encouraging.
    0:27:12 I agree.
    0:27:17 It’s super encouraging and more importantly democratizing that anybody can become a hit
    0:27:18 player.
    0:27:19 We were doing this in the federal government.
    0:27:20 I love that.
    0:27:24 But one of my questions is, when we had Adrian Cockroft on this podcast a couple of years
    0:27:27 ago talking about microservices, and the thing that I thought was so liberating about what
    0:27:34 he was describing the Netflix story was that it was a way for teams to essentially become
    0:27:40 little mini product management units and essentially self-organize because the infrastructure
    0:27:48 by being broken down into these micro pieces versus say a monolithic kind of uniform architecture,
    0:27:53 I would think that being a organization that’s containerized its code in that way that has
    0:27:58 this microservices architecture would be more suited to DevOps.
    0:28:00 Or is that a wrong belief?
    0:28:04 I’m just trying to understand again that taxonomy thing of how these pieces all fit together.
    0:28:07 So we actually studied this as a whole section of architecture in the book where we looked
    0:28:09 at exactly this question.
    0:28:12 Architecture has been studied for a long time and people talk about architectural characteristics.
    0:28:16 There’s the ATAM, the architectural trade-off model that kind of email and developed.
    0:28:21 There’s some additional things we have to care about, testability and deployability.
    0:28:27 Can my team test its stuff without having to rely on this very complex integrated environment?
    0:28:31 Can my team deploy its code to production without these very complex orchestrated deployments?
    0:28:34 Basically, can we do things without dependencies?
    0:28:38 That is one of the biggest predictors in our cohort of IT performance is the ability of
    0:28:43 teams to get stuff done on their own without dependencies on other teams, whether that’s
    0:28:46 testing or whether it’s deploying or whether it’s planning.
    0:28:47 Even just communicating.
    0:28:53 Can you get things done without having to do mass communication and checking in permissions?
    0:28:57 Question I love, love, love asking on this podcast is we always revisit the 1937 Coast
    0:29:02 paper about the theory of the firm and its idea that transaction costs are more efficient.
    0:29:07 This is like the ultimate model for reducing friction and those transaction costs, communication,
    0:29:08 coordination costs, all of it.
    0:29:11 That’s what all the technical and process stuff is about that.
    0:29:13 I mean, Don Robinson once came to one of my talks on continuous delivery.
    0:29:18 At the end, he said, “So, continuous delivery, that’s just about reducing transaction costs,
    0:29:19 right?”
    0:29:20 And I’m like…
    0:29:21 An economist view of DevOps.
    0:29:22 I love it.
    0:29:23 You’re right.
    0:29:25 You’ve reduced my entire body of work to one sentence.
    0:29:27 It’s so much Conway’s Law, right?
    0:29:28 This would remind me what Conway’s Law is.
    0:29:33 Organizations which design systems are constrained to produce designs which are copies of the
    0:29:35 communication structures of these organizations.
    0:29:36 Oh, right.
    0:29:39 It’s that idea basically that your software code looks like the shape of the organization
    0:29:40 itself.
    0:29:41 Right.
    0:29:42 And how we communicate, right?
    0:29:46 So, which, you know, Jez just summarized, if you have to be communicating and coordinating
    0:29:48 with all of these other different groups…
    0:29:52 Command and control looks like waterfall, a more decentralized model looks like independent
    0:29:53 teams.
    0:29:54 Right.
    0:29:55 So, the data shows that.
    0:29:58 A lot of people jump on the microservices, containerization, bandwagon.
    0:30:03 There’s one thing that is very important to bear in mind, implementing those technologies
    0:30:05 does not give you those outcomes we talked about.
    0:30:07 We actually looked at people doing mainframe stuff.
    0:30:10 You can achieve these results with mainframes.
    0:30:16 Equally, you can use the, you know, Kubernetes and, you know, Docker and microservices and
    0:30:17 not achieve these outcomes.
    0:30:22 We see no statistical correlation with performance, whether you’re on a mainframe or a greenfield
    0:30:24 or a brownfield system.
    0:30:28 If you’re building something brand new or if you’re working on existing build.
    0:30:31 And one thing I wanted to bring up that we didn’t before is I said, you know, day one
    0:30:32 is short, day two is long.
    0:30:36 And I talked about things that live on the internet and live on the web.
    0:30:40 This is still a really, really smart approach for package software.
    0:30:47 And I know people who are working in and running package software companies that use this methodology
    0:30:51 because it allows them to still work in small, fast approaches.
    0:30:56 And all they do is they push to a small package pre-production database.
    0:31:01 And then when it’s time to push that code onto some media, they do that.
    0:31:02 Okay.
    0:31:05 So what I love hearing about this is that it’s actually not necessarily tied again to the
    0:31:07 architecture or the type of company you are.
    0:31:11 There’s this opportunity for everybody, but there is this mindset of like an organization
    0:31:12 that is ready.
    0:31:14 It’s like a readiness level for a company.
    0:31:15 Oh, I hear that all the time.
    0:31:19 I don’t know if I’d say there’s any such thing as readiness, right?
    0:31:21 Like there’s always an opportunity to get better.
    0:31:24 There’s always an opportunity to transform.
    0:31:29 The other thing that really drives me crazy and makes my head explode is this whole maturity
    0:31:30 model thing.
    0:31:31 Okay.
    0:31:33 Are you ready to start transforming?
    0:31:38 Well, like you can just not transform and then maybe fail, right?
    0:31:42 Maturity models, they’re really popular in industry right now, but I really can’t stress
    0:31:47 enough that they’re not really an appropriate way to think about a technology transformation.
    0:31:50 I was thinking of readiness in the context of like NASA technology readiness levels or
    0:31:54 TRLs, which is something we use to think about a lot for very early stage things, but you’re
    0:31:58 describing maturity of an organization and it sounds like there’s some kind of a framework
    0:32:02 for assessing the maturity of an organization and you’re saying that doesn’t work, but first
    0:32:05 of all, what is that framework and why doesn’t it work?
    0:32:10 Well, so so many people think that they want a snapshot of their like DevOps or their technology
    0:32:14 transformation and spit back a number, right?
    0:32:18 And then you will have one number to compare yourself against everything.
    0:32:24 The challenge though is that a maturity model usually is leveraged to help you think about
    0:32:27 arriving somewhere and then here’s the problem.
    0:32:29 Once you’ve arrived, what happens?
    0:32:30 Oh, we’re done.
    0:32:31 You’re done.
    0:32:33 And then the resources are gone.
    0:32:38 And by resources, I don’t just mean money, I mean time, I mean attention.
    0:32:44 We see year over year over year, the best, most innovative companies continue to push.
    0:32:46 So what happens when you’ve arrived, I’m using my finger quotes.
    0:32:47 You stop pushing.
    0:32:48 You stop pushing.
    0:32:54 What happens when executives or leaders or whomever decide that you no longer need resources
    0:32:55 of any type?
    0:33:00 I have to push back again though, doesn’t this help because it is helpful to give executives
    0:33:04 in particular, particularly those that are not tech native, coming from the seeds of
    0:33:09 the engineering organization, some kind of metric to put your head around where are we,
    0:33:10 where are we at?
    0:33:12 So you can use a capability model.
    0:33:17 You can think about the capabilities that are necessary to drive your ability to develop
    0:33:20 and deliver software with speed and stability.
    0:33:24 Another limitation is that they’re often kind of a lockstep or a linear formula, right?
    0:33:25 No, right.
    0:33:28 It’s like a stepwise A, B, C, D, E, one, two, three, four.
    0:33:32 And in fact, the very nature of anything iterative is it’s very nonlinear and circular.
    0:33:33 Feedback loops are circled.
    0:33:34 Right.
    0:33:37 And maturity models just don’t allow that.
    0:33:42 No, another thing that’s really, really nice is that capability models allow us to think
    0:33:46 about capabilities in terms of these outcomes.
    0:33:48 Capabilities drive impact.
    0:33:53 Maturity models are just this thing where you have this level one, level two, level
    0:33:54 three, level four.
    0:33:55 It’s a bit performative.
    0:34:02 And then finally, maturity models just sort of take this snapshot of the world and describe
    0:34:03 it.
    0:34:05 How fast is technology and business changing?
    0:34:11 If we create a maturity model now, let’s wait, let’s say four years, that maturity model
    0:34:14 is old and dead and dusty and gone.
    0:34:16 Do new technologies change the way you think about this?
    0:34:20 Because I’ve been thinking a lot about how product management for certain types of technologies
    0:34:24 changes with the technology itself and that machine learning and deep learning might be
    0:34:25 a different beast.
    0:34:26 And I’m just wondering if you guys have any thoughts on that.
    0:34:27 Yeah.
    0:34:30 I mean, me and Dave Farley wrote the continuous delivery book back in 2010.
    0:34:34 And since then, you know, there’s Docker and Kubernetes and large-scale adoption of the
    0:34:37 cloud and all these things that you had no idea would happen.
    0:34:40 People sometimes ask me, you know, isn’t it time you wrote a new edition of the book?
    0:34:43 I mean, yeah, we would probably rewrite it.
    0:34:45 Does it change any of the fundamental principles?
    0:34:46 No.
    0:34:50 Do these new tools allow you to achieve those principles in new ways?
    0:34:51 Yes.
    0:34:54 So, I think, you know, this is how I always come back to any problem is go back to first
    0:34:55 principles.
    0:34:56 Yeah.
    0:34:59 And the first principles, I mean, they will change over the course of centuries.
    0:35:04 I mean, we’ve got modern management versus kind of scientific management, but they don’t
    0:35:06 change over the course of like a couple of years.
    0:35:08 The principles are still the same.
    0:35:11 These give you new ways to do them, and that’s what’s interesting about them.
    0:35:13 Equally, things can go backwards.
    0:35:17 A great example of this is one of the capabilities we talk about in the book is working off a
    0:35:22 shared trunk or master inversion control, not going on these long-lived feature branches.
    0:35:26 And the reason for that is actually because of feedback loops.
    0:35:29 You know, developers love going off into a corner, putting headphones on their head and
    0:35:34 just coding something for like days, and then they try and integrate it into trunk, you
    0:35:35 know, and that’s a total nightmare.
    0:35:38 And not just for them, more critically for everyone else who then has to merge their
    0:35:41 coding so whatever they’re working on.
    0:35:42 So that’s hugely painful.
    0:35:45 Git is one of these examples of a tool that makes it very easy for people like, “Oh, I
    0:35:46 can use feature branches.”
    0:35:49 So I think, again, it’s non-linear in the way that you describe.
    0:35:50 Right.
    0:35:51 Gives you new ways to do things, are they good and bad?
    0:35:52 It depends.
    0:35:55 But the thing that strikes me about what you guys have been talking about as a theme in
    0:35:59 this podcast that seems to lend itself, well, to the world of machine learning and deep
    0:36:03 learning where that technology might be different, is it sort of lends itself to a probabilistic
    0:36:09 way of thinking and that things are not necessarily always complete, and that there is not a beginning
    0:36:13 and an end, and that you can actually live very comfortably in an environment where things
    0:36:18 are by nature complex, and that complexity is not necessarily something to avoid.
    0:36:22 So in that sense, I do think there might be something kind of neat about ML and deep learning
    0:36:26 and AI for that matter, because it is very much lending itself to that sort of mindset.
    0:36:27 Yeah.
    0:36:30 And in our research, we talk about working in small batches.
    0:36:35 There’s a great video by Brett Victor called Inventing on Principle, where he talks about
    0:36:39 how important it is to the creative process to be able to see what you’re doing, and
    0:36:43 he has this great demo of this game he’s building where he can change the code and the game
    0:36:46 changes its behavior instantly when you’re doing things like that.
    0:36:48 You don’t get to see that.
    0:36:52 No, and the whole thing with machine learning is how can we get the shortest possible feedback
    0:36:56 from changing the input parameters to seeing the effect so that the machine can learn,
    0:37:01 and that the moment you have very long feedback loops, the ML becomes much, much harder because
    0:37:04 you don’t know which of the input changes caused the change in output that the machine
    0:37:06 is supposed to be learning from.
    0:37:10 So the same thing is true of organizational change and process, and product development
    0:37:14 as well, by the way, which is working in small batches so that you can actually reason about
    0:37:15 causing effects.
    0:37:16 I changed this thing.
    0:37:17 It had this effect.
    0:37:20 Again, that requires short feedback loops.
    0:37:21 That requires small batches.
    0:37:24 That’s one of the key capabilities we talk about in the book, and that’s what DevOps enables.
    0:37:28 So we’ve been this hallway style conversation around all these themes of DevOps, measuring
    0:37:31 it, why it matters, and what it means for organizations.
    0:37:36 But practically speaking, if a company, and you guys are basically arguing it, any company,
    0:37:40 not necessarily a “company” that thinks it’s a tech company, and necessarily a company
    0:37:44 that has this amazing modern infrastructure stack, it could be a company that’s still
    0:37:45 working off mainframes.
    0:37:48 What should people actually do to get started, and how do they know where they are?
    0:37:52 So what you need to do is take a look at your capabilities, understand what’s holding you
    0:37:56 back, try to figure out what your constraints are.
    0:38:02 But the thing that I love about much of this is you can start somewhere, and culture is
    0:38:04 such a core, important piece.
    0:38:09 We’ve seen across so many industries, culture is truly transformative.
    0:38:13 In fact, we measure it in our work, and we can show that culture has a predictive effect
    0:38:17 on organizational outcomes and on technology capabilities.
    0:38:23 We use a model from a guy called Ron Westrom, who was a social scientist studying safety
    0:38:27 outcomes, in fact, in safety-critical industries like healthcare and aviation.
    0:38:33 He created a typology where he organizes organizations based on whether they’re pathological, bureaucratic
    0:38:34 or generative.
    0:38:35 That’s actually a great topology.
    0:38:37 I wanted to apply that to people I date.
    0:38:38 I know, right?
    0:38:39 Too real.
    0:38:40 I wanted to apply it to people.
    0:38:41 Too real.
    0:38:42 There’s a book in there, definitely.
    0:38:46 I like how I’m trying to anthropomorphize all these organizational things into people.
    0:38:47 But anyway, go on.
    0:38:52 Instead of the five love languages, we can have the three relationship types.
    0:38:55 Pathological organizations are characterized by a low cooperation between different departments
    0:38:58 and up and down the organizational hierarchy.
    0:39:00 How do we deal with people who bring us bad news?
    0:39:03 Do we ignore them, or do we shoot people who bring us bad news?
    0:39:04 How do we deal with responsibilities?
    0:39:08 Are they defined tightly so that when something goes wrong, we know whose fault it is, so
    0:39:09 we can punish them?
    0:39:12 Or do we share risks, because we know we’re all in it together, and it’s the team?
    0:39:13 You all have to get in the game.
    0:39:14 You’re all accountable, right?
    0:39:15 Exactly.
    0:39:16 We’re all in different departments.
    0:39:18 And crucially, how do we deal with failure?
    0:39:23 As we discussed earlier, in any complex system, including organizational systems, failure
    0:39:24 is inevitable.
    0:39:28 So failure should be treated as a learning opportunity, not whose fault was it, but why
    0:39:32 did that person not have the information they needed, the tools they needed?
    0:39:35 How can we make sure that when someone does something, it doesn’t lead to catastrophic
    0:39:39 outcomes, but instead it leads to contained small blast radiuses?
    0:39:40 Right.
    0:39:41 Not an outage on Black Friday.
    0:39:42 Right.
    0:39:43 Exactly.
    0:39:45 So how do we deal with novelty?
    0:39:48 Is novelty crushed, or is it implemented, or does it lead to problems?
    0:39:52 One of the pieces of research that kind of confirms what we were talking about was some
    0:39:56 research that was done by Google, they were trying to find what makes the greatest Google
    0:39:57 team.
    0:40:01 You know, is it four Stanford graduates and no developer and fire all the managers?
    0:40:04 Is it a data scientist and a Node.js programmer and a manager?
    0:40:05 Right.
    0:40:08 One product manager paired with one system engineer, with one.
    0:40:14 And what they found was that the number one ingredient was psychological safety.
    0:40:17 Does the team feel safe to take risks?
    0:40:19 And this ties together failure and novelty.
    0:40:25 If people don’t feel that when things go wrong, they’re going to be supported, they’re not
    0:40:26 going to take risks.
    0:40:29 And then you’re not going to get any novelty, because novelty by definition involves taking
    0:40:30 risks.
    0:40:34 So we see that one of the biggest things you can do is create teams where it’s safe to
    0:40:39 go wrong and make mistakes, and where people will treat that as a learning experience.
    0:40:42 This is a principle that applies, again, not just in product development, you know, the
    0:40:46 lean start up, fail early, fail often, but also in the way we deal with problems at an
    0:40:48 operational level as well.
    0:40:50 And how we interact with our team when these things happen.
    0:40:54 So just to kind of summarize that, you have pathological, this is a power oriented thing
    0:40:58 where you know the people are scared, the messenger is going to be shot.
    0:41:02 Then you have this bureaucratic kind of rule oriented world where the messengers aren’t
    0:41:03 heard.
    0:41:07 And then you have the sort of generative, and again, I really wish I could apply this
    0:41:11 to people, but we’re talking about organizations here for culture, which is more performance
    0:41:12 oriented.
    0:41:15 And I just want to add one thing about this, you know, working in the federal government,
    0:41:17 you would imagine that to be a very bureaucratic organization.
    0:41:18 I would actually.
    0:41:22 And actually, what was surprising to me was that yes, there’s lots of rules.
    0:41:23 The rules aren’t necessarily bad.
    0:41:26 That’s how we can operate at scale is by having rules.
    0:41:28 But what I found was there was a lot of people who are mission oriented.
    0:41:32 And I think that’s a nice alternative way to think about generative organizations.
    0:41:34 You need to think about mission orientation.
    0:41:38 The rules are there, but if it’s important to the mission, we’ll break the rules.
    0:41:40 And we measure this at the team level, right?
    0:41:45 Because you can be in the government and there were pockets that were very generative.
    0:41:53 You can be in a startup and you can see startups that act very bureaucratic or very pathological.
    0:41:54 Right.
    0:41:55 The culture of the CEO.
    0:41:59 Where it’s not charismatic, inspirational vision, but to the expense of actually being
    0:42:01 heard and the messenger is shot, et cetera.
    0:42:05 And we have several companies around the world now that are measuring their culture on a
    0:42:09 quarterly cadence and basis because we show in the book how to measure it.
    0:42:12 Western’s typology was the table itself.
    0:42:16 And so we turn that into a scientific psychometric way to measure it.
    0:42:19 Now this makes sense why I’m putting these anthropomorphic analogies because in this
    0:42:22 sense organizations are like people.
    0:42:23 They’re made of people.
    0:42:24 Teams are organic entities.
    0:42:28 And I love that you said that the unit of analysis is a team because it means you can
    0:42:29 actually do something.
    0:42:31 You can start there and then you can like see if it actually spreads or doesn’t spread
    0:42:34 bridges, doesn’t bridge, et cetera.
    0:42:38 And what I also love about this framework is it also moves away from this cult of failure
    0:42:42 mindset that I think people tend to have where it’s like failing for the sake of failing.
    0:42:44 And you actually want to avoid failure.
    0:42:45 Right.
    0:42:48 And the whole point of failing is to actually learn something and then be better and take
    0:42:49 risks.
    0:42:50 So you can implement these new things.
    0:42:52 And very smart risks.
    0:42:53 So what’s your final?
    0:42:58 I mean, there’s a lot of really great things here, but like what’s your final sort of parting
    0:43:02 take away for listeners or people who might want to get started or think about how they
    0:43:03 are doing.
    0:43:06 So I think, you know, we’re in a world where technology matters.
    0:43:10 Anyone can do this stuff, but you have to get the technology part of it right.
    0:43:15 That means investing in your engineering capabilities, in your process, in your culture, in your
    0:43:17 architecture.
    0:43:20 We dealt with a lot of things here that people think are intangible and we’re here to tell
    0:43:21 you they’re not intangible.
    0:43:22 You can measure them.
    0:43:24 They will impact the performance of your organization.
    0:43:29 So take a scientific approach to improving your organization and you will read the dividends.
    0:43:32 When you guys talk about, you know, anyone can do this, the teams can do this, but what
    0:43:37 role in the organization is usually most empowered to be the owner of where to get started?
    0:43:39 Is it like the VP of engineering?
    0:43:41 Is it the CTO, the CIO?
    0:43:46 I was going to say, don’t minimize the role of and the importance of leadership.
    0:43:53 DevOps sort of started as a grassroots movement, but right now we’re seeing roles like VP and
    0:43:58 CTO being really impactful in part because they can set the vision for an organization,
    0:44:01 but also in part because they have resources that they can dedicate to this.
    0:44:04 We see a lot of CEOs and CTOs and CIOs in our business.
    0:44:05 We have like a whole briefing center.
    0:44:08 We hear what’s top of mind for them all the time.
    0:44:09 Everyone thinks they’re transformational.
    0:44:13 So like what actually makes a visionary type of leader who has that, not just the purse
    0:44:18 strings and the decision-making power, but the actual characteristics that are right
    0:44:19 for this.
    0:44:20 Right.
    0:44:21 And that’s such a great question.
    0:44:24 We dug into that in our research and we find that there are five characteristics that end
    0:44:31 up being predictive of driving change and really amplifying all of the other capabilities
    0:44:32 that we found.
    0:44:38 And these five characteristics are vision, intellectual stimulation, inspirational communication,
    0:44:40 supportive leadership, and personal recognition.
    0:44:46 And so what we end up recommending to organizations is absolutely invest in the technology.
    0:44:51 So invest in leadership in your people because that can really help drive your transformation
    0:44:52 home.
    0:44:56 Well, Nicole, Jez, thank you for joining the A6 and Z podcast.
    0:45:02 The book Just Out is Accelerate, Building and Scaling High-Performing Technology Organizations.
    0:45:03 Thank you so much, you guys.
    0:45:04 Thanks for having us.
    0:45:04 Thank you.

    One of the recurring themes we talk about a lot on the a16z Podcast is how software changes organizations, and vice versa… More broadly: it’s really about how companies of all kinds innovate with the org structures and tools that they have. 

    But we’ve come a long way from the question of “does IT matter” to answering the question  of what org structures, processes, architectures, and roles DO matter when it comes to companies — of all sizes  — innovating through software and more. 

    So in this episode (a re-run of a popular episode from a couple years ago), two of the authors of the book Accelerate: The Science of  Lean Software and DevOps, by Nicole Forsgren, Jez Humble, and Jean Kim join Sonal Chokshi to share best practices and large-scale findings about high performing companies (including those who may not even think they’re tech companies). Nicole was co-founder and CEO of Dora, which was acquired by Google in December 2018; she will soon be joining GitHub as VP of Research & Strategy. Jez was CTO at DORA; is currently in Developer Relations at Google Cloud; and is the co-author of the books The DevOps Handbook, Lean Enterprise, and Continuous Delivery.  

     

  • The Open Source CIO

    AI transcript
    0:00:05 The content here is for informational purposes only, should not be taken as legal business
    0:00:10 tax or investment advice or be used to evaluate any investment or security and is not directed
    0:00:14 at any investors or potential investors in any A16Z fund.
    0:00:18 For more details, please see a16z.com/disclosures.
    0:00:22 Hi, and welcome to the A16Z podcast.
    0:00:27 I’m Doss, and in this episode, we pull Mike Kelly, CIO of Red Hat, into a hallway style
    0:00:33 conversation with A16Z General Partner, Peter Levine, as part of our annual A16Z Innovation
    0:00:36 Summit, which happened late last year.
    0:00:38 We cover a lot of ground.
    0:00:43 They finish with M&A, given Red Hat has both been acquired and been an acquirer.
    0:00:48 Along the way, though, they touch on open hybrid architectures, when an open-source project
    0:00:52 becomes a product, and where services come in for an open-source startup.
    0:00:57 They start with a quick take from Peter on his classic post from 2014, why there will
    0:01:00 never be another Red Hat.
    0:01:09 Red Hat did such a great job in pioneering what I call open-source 1.0, the free and support
    0:01:15 model that their scale and capacity really made them a one-off.
    0:01:21 As a startup, to be able to go and create the same back-end infrastructure is quite expensive
    0:01:25 to go and do, so let me go one step further here.
    0:01:31 I don’t believe there will be another Red Hat with the Red Hat business model.
    0:01:37 However, I believe that there will be many, many, many successful open-source companies
    0:01:45 into the future that have different business models from Red Hat, that are further unlocking
    0:01:49 the potential of open-source, specifically open-source as a service.
    0:01:54 If we look at the history of open-source, as soon as the economics come into balance
    0:02:00 with the technology, we see entrepreneurs flourish, and the community flourishes because
    0:02:02 there’s sustainability.
    0:02:08 I think this whole SaaS open-source as a service has unlocked a whole new economic model.
    0:02:13 Peter’s article ended with maybe even Red Hat should think about becoming the next Amazon,
    0:02:17 and I think alluding to this kind of SaaS era that we’re in.
    0:02:21 How has that changed how you’re approaching open-source and open-source communities?
    0:02:25 Well, I think that our model started off as an on-prem subscription, which was pretty
    0:02:31 unique at the time, and as the public cloud has taken home, one of the benefits that we
    0:02:36 see is all of those technologies are built on the core asset that we have, which is Linux,
    0:02:41 and the different providers have different instantiations of that technology, different
    0:02:45 distributions of it, but our approach was to make sure that our technology runs on all
    0:02:49 of them because, to us, it doesn’t really make a difference.
    0:02:53 We have partnerships with all of the major cloud providers, and we obviously have our
    0:02:55 on-prem capabilities as well.
    0:02:59 The idea of this hybrid world is the one we placed a lot of bets on, the one that actually
    0:03:02 fortunately has evolved to be the dominant design.
    0:03:04 You talk a little bit about the dominant design.
    0:03:07 How do you view this emerging enterprise architecture?
    0:03:11 Where are we in that open or hybrid future?
    0:03:19 There was this view about five years ago, I would say, that the cloud takes over.
    0:03:21 There would be no more on-prem.
    0:03:25 There would only be one cloud provider, and now what we’re seeing is that there are multiple
    0:03:33 cloud providers, and the pendulum has sort of swung back to where there’s a right place
    0:03:40 for certain on-prem software and infrastructure and applications, and there’s the right use
    0:03:43 of the cloud.
    0:03:51 There are many tools now that makes the integration of public and private, i.e., hybrid, seamless
    0:03:54 across these different domains.
    0:03:58 Once we have that, there’s really no edge or core, there’s just compute.
    0:04:03 When we first started studying cloud and all of its different instantiations of what it
    0:04:08 was going to be and the hype that surrounded it, it was a binary thing.
    0:04:11 It was either you’re all public or you’re all on-prem, and it’s just like, “Come on,
    0:04:13 that doesn’t make any sense.”
    0:04:18 What has come to fruition now, I think, is everybody starting to recognize all the choice
    0:04:23 that’s available, all the just incredible amount of innovation that’s taken place, that for
    0:04:28 someone in a job like mine, it’s our responsibility and our job to take advantage of it.
    0:04:35 The means by which I can manage it is almost as important as the means in which I can just
    0:04:36 use it.
    0:04:43 Here in my job, your partners and other functions in the company shouldn’t care what’s underneath
    0:04:44 the solution.
    0:04:48 All they should care about is that the solution is correct, and it’s optimized both for agility
    0:04:51 and cost purposes for whatever problem you’re trying to solve.
    0:04:55 Peter, you’ve said software as a service has really cracked open-source in terms of its
    0:05:01 valuations and its potential, but at the same time, the end customer doesn’t really know
    0:05:03 if it’s open-source or not.
    0:05:09 From a development standpoint, we get all the innovation, the community, the bug fixing
    0:05:15 that open-source has been great at for the past 30, 40 years, but really we can monetize
    0:05:21 open-source at the full value of that software because people don’t care.
    0:05:23 All they want is the service.
    0:05:29 Just give me whatever that software provides, and I don’t really care whether it’s open-source
    0:05:35 or not, and oh, by the way, I’m willing to pay full value for that stack.
    0:05:42 In the 1.0 era, the economic problem, and I ran an open-source company in the 1.0 era,
    0:05:49 I know the economic problem, is a buyer would compare, would say, “Okay, you’re giving away
    0:05:56 your software for free and charging for support, and I’m going to go compare you to your proprietary
    0:06:04 counterpart,” and the proprietary counterpart charges 80 cents for the software and 20 cents
    0:06:05 for support.
    0:06:10 Therefore, we’re going to only pay you 20 cents because all you’re doing is providing
    0:06:11 support.
    0:06:18 Now, if it’s run as a service and support and the service of the software is all built
    0:06:25 in together, it’s 100 cents, and let me also add that going from open-source bits, the source
    0:06:34 code to creating a reliable, manageable service, there’s a lot of work in that.
    0:06:38 It’s not like you have open-source, and all of a sudden, you cobble this stuff together
    0:06:41 and you get open-source as a service.
    0:06:46 There’s a huge difference between a project and a product, and that is really, really
    0:06:53 important, especially if you’re in my role in a company and you are inevitably going
    0:06:58 to have members of your team saying, “Well, we’ll just get the free version,” and it’s
    0:07:01 like, “Okay, well, who’s going to patch it?
    0:07:07 Who are we relying on to provide feature function updates, integration, et cetera, et cetera,
    0:07:08 et cetera?”
    0:07:13 The notion that people don’t care because it’s a service, I think is true to a certain
    0:07:18 extent, but the person that’s ultimately responsible ought to care on who’s behind the scenes.
    0:07:23 The good thing is all this innovation that’s happening, especially in the software, in
    0:07:26 the infrastructure and cloud space, it’s all user-driven innovation.
    0:07:31 It’s all people that are practitioners that have a problem, and they try to go solve the
    0:07:37 problem, and there’s a group that rallies around it, and the dominant design forms, and then
    0:07:41 it would take the upstream project and create products.
    0:07:45 You mentioned this idea of the difference between a project and a product.
    0:07:49 How do you evaluate or think about that difference?
    0:07:53 What tells you something is no longer just a project, it’s a fully-baked product?
    0:07:55 You as an IT buyer might want to invest in.
    0:07:59 Well, I think when a company stands up and puts some service around it, anybody can go
    0:08:05 get the community version of a piece of software and use it as they see fit.
    0:08:10 The minute it becomes a product is when a company says, “We offer a business model around
    0:08:12 that particular project.”
    0:08:16 It’s interesting what happened with the role of IT in a lot of companies.
    0:08:21 For the longest time, what is our core competency was the discussion, and we said, “Well, we’re
    0:08:30 really not great at IT, so we should try to run that at an optimal cost and look for partners
    0:08:34 that can run it better than we end because we’re not in the IT business.”
    0:08:38 Back in that time, open source was mostly a commodity play.
    0:08:41 That’s how Red Hat got put on the map, was we were commoditizing a product.
    0:08:47 Nowadays, where every company is all of a sudden a technology company, and companies are looking
    0:08:52 to IT as, “Oh, we’re going to use technology to disrupt our competitors.”
    0:08:57 People are in a job like mine, have to sort of retool ourselves, having the capability
    0:09:03 for one individual team to run a distribution of open source software if the community version
    0:09:08 is more tricky than having a trusted advisor partner with you and do it side by side.
    0:09:13 As a buyer, I encourage everybody to inspect pretty heavily what’s behind the scenes there,
    0:09:16 and how do I know who’s hand to shake when everything goes really well?
    0:09:19 Let’s say I start an open source company.
    0:09:24 When does Red Hat say, “We’re going to grab those bits and put them into our distribution
    0:09:27 versus we’re going to allow that company to exist?”
    0:09:33 There’s always the self-rationalized argument, which I would do if I were Red Hat to say,
    0:09:37 “Look, our customers want one stop, and for anything infrastructure, we’re going to go
    0:09:41 off for that because that’s what our customers are asking for.”
    0:09:45 Maybe help me and us to understand how you think about that.
    0:09:49 First and foremost, you’ve got to look through it through the filter of what is our strategy?
    0:09:50 What are we going after?
    0:09:56 There are lots of parts of the enterprise where we have not played historically, and
    0:09:59 there are parts where we play and we would try to play well.
    0:10:00 So we’re always looking at the portfolio.
    0:10:01 What’s the right mix?
    0:10:03 What’s the right value proposition for us?
    0:10:04 It’s interesting.
    0:10:12 Just from an entrepreneur’s viewpoint, if I start company A versus B, what’s the likelihood
    0:10:19 that Red Hat is either going to want to partner with me or adopt that technology?
    0:10:26 From my lens, if the company that’s founded is the founder of the project is the CEO and
    0:10:31 the five people that he worked with on the project, maybe there’s seven or eight employees
    0:10:36 total, I’m probably going to scratch my head about that in terms of the longevity and just
    0:10:38 the sustainability of it.
    0:10:42 It might be good for some experimental stuff I’m doing in my shop, but for production type
    0:10:43 stuff you’ve got to think twice about it.
    0:10:44 Yeah, for sure.
    0:10:49 But those companies that are small, they start out that way and then they get a tailwind
    0:10:51 and then now they’re 50 people.
    0:10:59 At that point, as was with the company that I ran, we got to be of a scale where customers
    0:11:02 actually trusted us and we could go do things.
    0:11:05 As somebody in IT who’s kind of evaluating these different projects, maybe the first
    0:11:11 ones to test things out, as you mentioned, how do you decide which bets are worth making
    0:11:13 from a technology perspective?
    0:11:14 What are you looking for?
    0:11:16 Every CIO on the planet is trying to do this.
    0:11:21 You’re trying to balance operational excellence and running the business with innovation and
    0:11:23 driving the business forward.
    0:11:28 Again, if much of the innovation is coming from the open source community, then a lot
    0:11:34 of the bets that you’re placing for new technologies are rooted in solutions that are born there.
    0:11:38 For me, I always try to think about how are we balancing those two things because it’s
    0:11:40 really important.
    0:11:45 If all you do is focus on keeping the lights on and making sure everything hums, you’re
    0:11:49 going to miss opportunity to drive the business forward.
    0:11:53 To me, it’s all about striking a balance and our team, we spend a lot of time thinking
    0:11:55 about what are the strategic priorities of the company?
    0:11:57 How do we want to translate those in IT?
    0:11:59 Where can we take some calculated risks?
    0:12:05 Really curious to just hear how that has informed product development within Red Hat and what
    0:12:09 sort of advice you might have for others in terms of using their own software to advance
    0:12:10 it.
    0:12:11 We have a program within Red Hat.
    0:12:14 It’s called Red Hat on Red Hat.
    0:12:17 I made it pretty clear from the beginning that that doesn’t mean by default we’re just
    0:12:18 going to choose our products.
    0:12:20 I mean, they have to work.
    0:12:27 We had to create some bridges and some trust with engineering and try to demonstrate that
    0:12:31 we could be that customer zero and drink our own champagne.
    0:12:35 What advice do you have, I guess, for somebody who’s in that process of trying to build that
    0:12:36 feedback loop?
    0:12:43 What does it take to get trust between IT or your internal customer and engineering to
    0:12:45 actually get them to listen to that feedback?
    0:12:49 You have to prove that what you’re really hired to do, which is make sure the company
    0:12:53 runs, is happening really, really well and garner some respect and some credibility that
    0:12:54 way.
    0:12:56 Then you can start to build trust.
    0:13:00 If all you’re focusing on is giving feedback and the servers go down every five minutes,
    0:13:01 you can have a problem.
    0:13:06 To me, I’ve always viewed the ability for us to deploy Red Hat’s product and give feedback
    0:13:08 is a privilege.
    0:13:12 We have to earn that because if you don’t, you’re just a noisy distraction.
    0:13:16 Let’s talk a little bit about mergers and acquisitions because I think that’s an example
    0:13:21 where often you’re looking to buy innovation or core functionality.
    0:13:27 How do you then as an IT department approach integrating that in?
    0:13:34 Every acquisition and coming together of companies or divestiture or whatever, they’re all different.
    0:13:35 I’ve been through a lot of them.
    0:13:40 To me, the common denominator in all of them is a deep understanding of the culture of
    0:13:44 each company because that will determine how close you want to be and how far apart
    0:13:49 you need to remain with the focus on the original thesis for why you’re buying the company in
    0:13:50 the first place.
    0:13:53 In a lot of cases, open source companies, it’s about the people.
    0:13:57 If you buy a company for the people that are there and you try to integrate things, people
    0:14:00 don’t want integrated, you destroy all the value while you bought it the first place.
    0:14:04 There’s a spectrum of M&A.
    0:14:12 If you’re acquiring a small organization and it’s the few technical people, that’s very
    0:14:18 different than acquiring a much larger company that has a full sales, marketing kind of whole
    0:14:19 energy around it.
    0:14:27 I mean, you guys were just acquired by IBM, so there you go, tiny companies swallowed
    0:14:31 by a giant.
    0:14:34 There was a lot beyond the technical capabilities.
    0:14:39 There’s a lot of channel and go-to-market capabilities, and you all are pretty independent
    0:14:46 from IBM, so that’s an example of full independence because I would imagine the two cultures when
    0:14:52 integrated together might have really hampered the technical and go-to-market capability
    0:14:56 of Red Hat, and so therefore, in that case, you leave it alone.
    0:15:03 In other cases, you would combine things to where, let’s say, in my company, we were acquired,
    0:15:08 and we leveraged the sales organization of the acquiring company, but we’re standalone
    0:15:14 from a technical standpoint because it was believed that our product fed into a much larger
    0:15:20 sales organization would increase the traction as opposed to us doing it alone.
    0:15:26 From a spreadsheet standpoint, when the two companies meet initially, everything looks
    0:15:27 wonderful.
    0:15:31 It’s one plus one equals three, everything’s accretive, we’re going to go do all these
    0:15:37 great things, and a lot of times it doesn’t quite work out that way, and a lot of it has
    0:15:44 to do with integration and how you think about the operating framework of the two organizations
    0:15:45 post-acquisition.
    0:15:51 My view is, if you take the time and study that and you get it right, the spreadsheet
    0:15:57 model that was produced will be proven to be incorrect because you’ll beat it by so much.
    0:16:05 My advice to entrepreneurs I gave myself this advice was if you are considering an acquisition,
    0:16:10 think about the level of autonomy that you are comfortable with once you’re inside the
    0:16:17 new organization, because let’s say I’m the CEO of my company, even if there’s five people
    0:16:22 in my company, I’m the one who’s making all the decisions, and then you’re acquired by
    0:16:27 a larger organization, in the new company you might be a director in the engineering group
    0:16:33 with five direct reports, so I would really think about your own level of happiness inside
    0:16:38 this big company, am I going to be able to really do what I need to do?
    0:16:39 That’s fascinating.
    0:16:42 That’s not something I’ve heard talked about a lot, because usually people are thinking
    0:16:47 about the dollar amounts, the valuations, and that’s a very human component to it.
    0:16:51 The dollar part, of course, is a factor.
    0:16:58 The company that’s acquiring the small company wants that team to stay, so they may negotiate
    0:17:03 a deal where you get paid out over three years, and you don’t get it all up front.
    0:17:08 If you’re making a commitment to the buying organization that me and my team, we’re going
    0:17:13 to stick around, and the day after you get your payday you leave, that’s a credibility
    0:17:14 issue.
    0:17:19 I think it’s very important to make sure that if you are committing to stay, or let’s even
    0:17:27 say financially, you are incented to stay, make sure it’s a job that you’re able and
    0:17:30 willing to go and do, otherwise stay independent.
    0:17:34 But don’t fool yourself into believing that if it’s a miserable environment that you’re
    0:17:38 going into, that you’re just going to be happy because you happen to get paid.
    0:17:40 It’s like basic relationship advice.
    0:17:42 If it’s bad now, it’s probably going to be bad later.
    0:17:43 Right.
    0:17:47 As an entrepreneur, as a CEO, you have an obligation to your team.
    0:17:52 They’re going to trust that you’re going to make the right decision, put that team in
    0:17:58 a reasonably good place in the new organization, and those are the discussions that I would
    0:18:04 have with the acquiring organization to make sure that everything aligns beyond just the
    0:18:06 financial numbers.
    0:18:11 It is a negotiation with the acquiring company because if I’m, let’s say, an entrepreneur
    0:18:15 and I have a couple of hundred people and I have a sales organization, the best case
    0:18:21 for me is that we’re left as an independent company, and all we do is get funding from
    0:18:22 the mother ship.
    0:18:28 Now, the acquiring company may say, “Well, wait a minute, we have this tremendous go-to-market
    0:18:36 engine with 3,000 salespeople and marketing and all that, and we believe that it’s better
    0:18:43 for your sales to actually be incorporated into our sales so we don’t have confusion
    0:18:46 at the customer’s side.”
    0:18:52 That’s a negotiation, and then whatever you come up with, you want to make sure that it’s
    0:18:57 durable and that everyone is reasonably happy with the outcome.
    0:19:03 For me, it was all about establishing the guiding principles upfront, knowing that there’s
    0:19:08 probably somebody who’s done something like this before, and you should go talk to them.
    0:19:14 If a large company is acquiring a small company, chances are that large company has done many,
    0:19:16 many, many acquisitions.
    0:19:22 There are plenty of people to go talk to inside the company to say, “Hey, how did it go?
    0:19:24 What would you do differently?”
    0:19:28 Furthermore, these acquisitions have to be successful.
    0:19:34 There are big deals, and some manager is on the hook to make them work successfully, maybe
    0:19:36 all the way up to the CEO.
    0:19:42 If there are elements that the acquiring company can improve relative to their overall process
    0:19:48 or org design or whatever, they’re happy to go and make those changes.
    0:19:54 I think that goes back into community and how you’re treating the communities that you
    0:19:55 become the custodians of.
    0:19:59 What advice do you have for somebody who’s managing an open-source project to be good
    0:20:02 custodians of the community?
    0:20:06 My advice would be stay focused on the problem you’re trying to solve, be a good citizen
    0:20:11 of the community, build partnerships, and continue to recognize that it’s not about
    0:20:12 you, it’s about us.
    0:20:13 I think that’s a great note to end on.
    0:20:15 I just want to say thank you, Mike.
    0:20:16 Thank you, Peter, for joining.
    0:20:17 Sure.

    In 2014, in “Why There Will Never Be Another Red Hat,” Peter Levine argued that Red Hat’s open source business model of commercializing support and services was highly difficult to replicate. Instead, he predicted the future of open source companies would be open source-as-a-service. And today SaaS has emerged as the dominant business model.

    In this podcast, recorded as a hallway-style conversation as part of the a16z Innovation Summit last year, Peter chats with Red Hat CIO, Mike Kelly, about what it means to be an open source CIO today – and how even Red Hat is evolving in the open SaaS era. They cover everything from why open hybrid has become the dominant enterprise architecture to how CIOs should think about adopting new technologies to what it takes for an M&A to be successful, beyond the spreadsheets.

  • Novel Coronavirus Updates: How Healthcare System, Tests Work; More

    AI transcript
    0:00:07 Hi everyone, welcome to the A6NZ podcast, I’m Sonal.
    0:00:12 We’ve been covering the novel coronavirus and COVID-19 disease on our other show, 16
    0:00:16 Minutes, which you can find in a separate feed if you haven’t subscribed already, but
    0:00:22 given that the topic of health system preparedness is top of mind right now and that the latest
    0:00:28 CDC briefing touched on issues with test kits, the patient perspective of how the U.S. health
    0:00:32 care system works, with clinicians calling the health department and so on, we’re running
    0:00:38 last week’s episode of 16 Minutes in this feed because in it we covered how these tests
    0:00:44 work, how the U.S. health care system works today when it comes to epidemics and preparedness
    0:00:46 and where we might go in the future.
    0:00:54 As a reminder, you can visit cdc.gov and who.int for more information, but as of now, the World
    0:00:58 Health Organization reported on February 25th that for the first time since the onset of
    0:01:04 symptoms of the first identified case of COVID-19, there have been more new cases reported from
    0:01:09 countries outside of China than from China, and the CDC reported on February 26th that
    0:01:15 there’s news about community spread, which means that cases of COVID-19 are appearing
    0:01:18 without a known source of exposure.
    0:01:23 And those communities currently include Hong Kong, Italy, Iran, Singapore, South Korea,
    0:01:25 Taiwan, and Thailand.
    0:01:29 So that’s the latest updates, now onto last week’s episode.
    0:01:34 Hi everyone, welcome to the 23rd episode of 16 Minutes, our show where we cover the headlines
    0:01:38 and what’s in the news, what’s happening, and tease apart what’s hype, what’s real
    0:01:39 from our vantage point in tech.
    0:01:41 I’m Sonal.
    0:01:44 Today we’re doing another update on the topic of coronavirus.
    0:01:48 We did a deeper dive in episode 21, which you can find in this feed or on our website
    0:01:51 at a6nz.com/16minutes.
    0:01:55 Much of that background is still relevant today, but in this episode we’re going to
    0:01:56 cover two segments.
    0:02:00 First, we’ll do a high-level overview of some of the practical implications for the U.S.
    0:02:05 healthcare system with a6nz.bio general partner Julie Yu, and then the second segment is a
    0:02:09 quick situation update from our previous episode with Judy Svitskaya.
    0:02:12 As a reminder, all the sources and reports cited in this episode will be included in
    0:02:16 the show notes, and we are not covering the clinical infectious disease specifics as we
    0:02:20 will bring on our other experts for that in an upcoming episode.
    0:02:21 So that’s a context.
    0:02:25 Now before we chat, let me quickly share the latest updates, which are that the day after
    0:02:30 we dropped our last episode, the World Health Organization declared on January 30th that
    0:02:34 the coronavirus outbreak is a, quote, “public health emergency of international concern.”
    0:02:37 And then the day after that, the Health and Human Services Secretary of the United States
    0:02:41 declared a public health emergency to aid the nation’s healthcare community in responding
    0:02:45 to the novel coronavirus, which, by the way, was officially named last week.
    0:02:48 It is now known as COVID-19.
    0:02:52 And to be clear, that’s the name of the disease, not the virus, which, as mentioned in our
    0:02:58 last episode, was known as 2019 NCOV, but is now known as SARS-CoV-2.
    0:03:03 And then also, as of last week, a lot happened in a week, the CMS, the U.S. Centers for
    0:03:08 Medicare and Medicaid Services, developed a new billing code for providers and laboratories
    0:03:12 to test patients for this virus that causes COVID-19.
    0:03:16 And we’ll share details about how that test works in the second half of this episode, as
    0:03:18 well as the latest global numbers.
    0:03:22 But first, now let’s cover the U.S. care delivery aspects.
    0:03:28 According to the CDC, as of February 17th, there are a total of 467 persons under investigation
    0:03:34 for this in the United States, identified across 42 states, with 15 confirmed positive
    0:03:36 for it and 60 pending.
    0:03:40 So Julie, practically speaking, what’s actually happening here in our health care system as
    0:03:41 it works today?
    0:03:43 What happens when someone walks into a hospital?
    0:03:47 So it depends a lot on where you’re walking into.
    0:03:53 Most of the time, because our health care system is characterized by such access constraints,
    0:03:56 you may see a lot of these patients actually showing up in the emergency room.
    0:04:01 What happens is that they will check in with a registrar, essentially, and be asked, “What
    0:04:02 is your reason for being here?”
    0:04:05 Typically, they’ll also be collecting your insurance information.
    0:04:07 You will do a physical visual assessment.
    0:04:09 They might ask some very generic questions.
    0:04:14 One of the training motions that’s happening in hospitals is that people are trying to
    0:04:18 train those frontline staff to ask questions like, “Have you traveled to China in the last
    0:04:19 two weeks?”
    0:04:20 Et cetera.
    0:04:24 And so you have to deploy field resource to make sure that even those frontline questions
    0:04:25 are being asked.
    0:04:26 Right.
    0:04:27 I get it.
    0:04:30 Sort of the difference between a generalist triage model and a more specialist triage
    0:04:31 model.
    0:04:32 Exactly.
    0:04:33 Because that’s the biggest blind spot right now.
    0:04:36 One of the big risks of this particular virus is that the pre-syntomatic period while you
    0:04:39 are still contagious is fairly lengthy.
    0:04:42 And so that’s one of the big sort of gaps right now is, you know, how do we just identify
    0:04:43 those people?
    0:04:46 So after they go through the ER and then what happens?
    0:04:51 So assuming that people are being appropriately assessed and there is a determination that
    0:04:56 there’s a potential risk that you are a coronavirus patient, you administer the test, again, assuming
    0:05:00 that the test kits are in supply and based on those results.
    0:05:05 If the patient is quarantined and assuming, again, that they are in an acute care facility
    0:05:10 that has infrastructure to actually perform an appropriate quarantine, typically those
    0:05:14 quarantine rooms are what are called negative pressure rooms, which basically means the
    0:05:18 air in that room is sort of minimal seepage externally.
    0:05:21 You’re essentially isolating the potential germs and contagion.
    0:05:26 But again, that sort of begs again the point of, “Are you showing up at an ED of a facility
    0:05:28 that actually has all this infrastructure?”
    0:05:32 Many of these patients might just be walking into an urgent care clinic or a primary care
    0:05:33 clinic.
    0:05:37 And so oftentimes it might be the case that the patient could get sent home or referred
    0:05:41 into one of these facilities with further delay, further exposure points, et cetera.
    0:05:46 So basically there’s a potential for a lot of chaos on the front lines because we don’t
    0:05:49 clearly understand where the risk points are.
    0:05:53 And we’re sort of waiting for the patients to essentially show up versus being able to
    0:05:54 be proactive.
    0:05:55 Right.
    0:05:56 And how about on the treatment side?
    0:05:57 So there currently is no treatment for this.
    0:06:02 My partner Jorge and I, and Jorge being an expert in genomics, oftentimes talk about the
    0:06:07 areas of medicine and healthcare where clearly there’s an application for technology that
    0:06:11 makes complete sense, but oftentimes it’s the business model component of it that holds
    0:06:12 things back.
    0:06:13 What do you guys mean by that?
    0:06:19 So we have the capabilities to rapidly sequence bugs and other viral forms.
    0:06:25 And there’s in theory a capability that says if you are able to quickly identify and rapidly
    0:06:30 identify in the field, what type of bug you’re dealing with, that you could also synthesize
    0:06:36 a vaccine on demand based on the fact that we can increasingly print genomic tools and
    0:06:37 genomic content.
    0:06:38 That’s technically possible right now?
    0:06:39 The technology exists.
    0:06:41 It’s not yet been deployed into practice.
    0:06:45 There’s still a great degree of validation and testing.
    0:06:49 Obviously we have a very rigorous system through which these types of technology are brought
    0:06:53 to market with regards to clinical trials and regulation and whatnot.
    0:06:58 The other piece is historically vaccines and other types of treatments like this have not
    0:07:03 been a lucrative area for businesses to go into for a number of reasons.
    0:07:08 And that’s another area that’s TBD is can you actually find the reimbursement path for
    0:07:09 getting these products to market?
    0:07:10 Okay.
    0:07:13 So where we are right now, it seems like the focus is on what I’m calling the 3Gs, gowns,
    0:07:14 goggles, and gloves.
    0:07:19 I’m also very interested at a broader level because the World Health Organization did their
    0:07:22 first annual report on global preparedness for health emergencies.
    0:07:25 They basically wrote in their report, just came out last year, and they have targets
    0:07:30 to September 2020 for progress towards that, that countries, donors, and multilateral institutions
    0:07:35 must be prepared for the worst, quote, “A rapidly spreading pandemic due to a lethal
    0:07:40 respiratory pathogen, whether naturally emergent or accidentally or deliberately released,
    0:07:44 poses additional preparedness requirements, and that we must ensure adequate investment
    0:07:48 in developing innovative vaccines and therapeutics as you talked about, surge manufacturing capacity,
    0:07:51 appropriate non-pharmaceutical interventions, et cetera, et cetera.”
    0:07:53 I guess I have two questions for you here.
    0:07:58 One, where are we as a country from a systemic point on that readiness?
    0:08:01 And then two, what does it say about where we should be?
    0:08:05 So this to me is one of the biggest cases to be made for this concept of the unbundling
    0:08:06 of the hospital.
    0:08:12 When you look back at the history of how the facility side of healthcare has evolved, hospitals
    0:08:16 were something that were born in the last century or so on the premise that if you were
    0:08:21 to centralize the scarce resources, the doctors, the clinicians in a central location that
    0:08:22 you could get efficiencies.
    0:08:27 And by the way, also have the infrastructure, like the op-ex and cap-ex required to do big
    0:08:30 labs and centralize the facilities and high-end procedures.
    0:08:31 Right.
    0:08:32 Exactly.
    0:08:33 Not just the people.
    0:08:34 Exactly.
    0:08:37 And so the unfortunate consequence of that is that, yes, you can have these now very
    0:08:41 high-end facilities that perform very advanced procedures, but where, again, we are forcing
    0:08:45 the patients to travel outside of their homes, but also get exposed to others who have other
    0:08:46 illnesses.
    0:08:51 In fact, hospital-acquired infections are one of the major contributors to comorbidities
    0:08:53 for patients who come to these acute care facilities.
    0:08:56 We are in the middle of flu season, remember?
    0:08:57 Yes.
    0:09:01 So you’re already having rooms full of patients who suspect that they have some kind of illness.
    0:09:05 That’s kind of like an iconic motion within our healthcare system is that we force patients
    0:09:11 to come to these central monolithic facilities to get any kind of care versus going to them,
    0:09:12 making it convenient to them.
    0:09:16 And actually, it’s interesting that when you look back in the early 1900s, nearly half
    0:09:19 of healthcare was actually delivered in the home.
    0:09:22 Less than 1% of healthcare is now delivered in the home, even for the most senior and
    0:09:24 frail patients in America.
    0:09:25 Right.
    0:09:28 And it’s also an access issue, because it means that people who can’t afford or live
    0:09:33 in big hubs where you can afford these types of high, varying quality.
    0:09:38 What that’s predicated on, though, it requires productization of the types of technologies
    0:09:42 that you see in these hospital settings in such a way that can be decentralized.
    0:09:47 A great basic but kind of elegant example of this is you see companies, one in particular
    0:09:50 comes to mind that is doing a connected thermometer.
    0:09:53 It’s marketed towards parents as something that they can use for their kids.
    0:09:58 And when you look at the back end of their business, it’s basically a data company that
    0:10:03 is acting as a sentinel to collect information about temperatures in communities and essentially
    0:10:07 predict when there will be a flu outbreak or a cold outbreak, et cetera.
    0:10:12 And they actually notify not only the end users, but they have connectivity into schools,
    0:10:14 churches, other institutions.
    0:10:19 And you can imagine that a system like that at scale for various types of diseases could
    0:10:22 actually enable this sort of truly decentralized model.
    0:10:27 But the only way that this can happen is if you have interoperable data systems that can
    0:10:32 not only collect data from the clinical setting and make it readily available on an ad hoc
    0:10:37 basis and across facilities across the country, but also take into account non-traditional
    0:10:41 data sources like these smart devices that are connected in the communities to augment
    0:10:44 your visibility across patient populations.
    0:10:45 Okay.
    0:10:47 So that’s sort of the unbundling of the hospital.
    0:10:51 In that context, it all comes together like connects the dots.
    0:10:56 This is how interoperability and data liquidity and data from unconventional sources and all
    0:10:58 this stuff comes together.
    0:11:01 That’s on the future of where we could go and what the ideal state could be.
    0:11:04 What are some of the things that can happen now inside the hospital?
    0:11:07 There’s, I would say, the human elements, the operational elements, and then the technology
    0:11:08 elements.
    0:11:14 So on the human side, this is what these organizations are sort of designed to do is deploy large
    0:11:19 swaths of human labor in such a way that can sort of react to healthcare needs.
    0:11:24 Operationally speaking, we mentioned earlier the logistics of how a patient flows through
    0:11:25 the hospital.
    0:11:28 You need to anticipate all the potential entry points that patients are coming in.
    0:11:32 The hospital these days are health systems, really, and they need to have connectivity
    0:11:37 into their primary care clinics, their urgent care clinics, et cetera, to really understand
    0:11:40 systematically what’s going on across the network.
    0:11:41 And now the tech part.
    0:11:42 That’s what I’m most interested in given your vantage point.
    0:11:43 Yeah.
    0:11:44 Here’s what I’m going to say.
    0:11:48 One nice thing about EHRs now, they are literally the primary tool that frontline clinicians
    0:11:50 are using.
    0:11:56 You’ve seen this now, hospitals literally interjecting very basic questions into the medical record
    0:12:01 to prompt them to ask the things that could qualify whether or not a patient might potentially
    0:12:03 be at risk for coronavirus.
    0:12:08 So that’s where the fact that we now have this broad infrastructure layer laid down can
    0:12:12 actually provide tremendous value in that you can make one change that does get propagated
    0:12:15 to all of the endpoints in the care delivery system.
    0:12:17 So doing things at scale through technology, basically.
    0:12:22 So bottom line for me, Julie, how should we think about this in terms of the tech and
    0:12:26 the delivery side and preparedness for the epidemic at that level?
    0:12:31 I think this is shedding light on the fact that we as a healthcare system have many nodes
    0:12:37 of potential failure when it comes to widespread epidemics and pandemics, but the direction
    0:12:42 and everything that we’ve talked about around the notion of decentralization, of unbundling
    0:12:48 of hospital, of using technology and distributed data streams to be able to be more responsive
    0:12:51 and nimble is coming to light.
    0:12:54 And so we will take learnings from this and apply it towards what the future of healthcare
    0:12:55 needs to look like.
    0:12:56 Thank you for joining this segment.
    0:12:57 All right.
    0:12:58 Thank you so much.
    0:13:01 Now let me introduce Judy Savitskaya on the A6NZ Bio team.
    0:13:02 Welcome, Judy.
    0:13:03 Thanks, Donald.
    0:13:04 Okay.
    0:13:07 So let me just give a quick update on the stats of the disease.
    0:13:11 This is Situation Report Number 25 from the World Health Organization.
    0:13:13 We just came out February 14th.
    0:13:16 Here’s the high-level summary of the numbers.
    0:13:21 So globally, there are now 49,053 laboratory-confirmed cases.
    0:13:26 In China, there are 48,548 laboratory-confirmed ones.
    0:13:31 And then outside of China, there are 505 across 24 countries with two deaths outside of China.
    0:13:35 The other thing, though, is there was a huge spike in the numbers.
    0:13:39 And that was because they will include the number of clinically diagnosed cases into
    0:13:43 the number of confirmed cases so that patients could receive timely treatment.
    0:13:46 And previously, patients could only be diagnosed by test kits.
    0:13:47 What does this mean scientifically?
    0:13:48 Yeah.
    0:13:53 So these cases have in the past been basically labeled as coronavirus cases, whether they
    0:13:56 have the right nucleic acid sequence that belongs to that virus.
    0:14:01 What they’re saying now is that they’re also going to count anybody who is symptomatic
    0:14:05 in all the same ways that the virus has been presenting itself in other patients and has
    0:14:06 the CT scan evidence.
    0:14:11 So the former FDA commissioner, Scott Gottlieb, noted that this is happening because it’s
    0:14:14 in the absence of a PCR test, which we briefly talked about last time.
    0:14:18 There’s an open question about why these are not yet available at scale.
    0:14:21 But can you give us a little bit more detail about what is the PCR test scientifically?
    0:14:22 Yeah.
    0:14:27 So PCR test stands for polymerase chain reaction, basically with amplifying a piece of DNA or
    0:14:31 RNA nucleic acid by copying it over and over and over again.
    0:14:35 What you’re doing in this test is basically you’re taking a sample from the patient.
    0:14:37 There’s some nucleic acids in there.
    0:14:41 The sequence is very long, but you take a small sequence of DNA, RNA, whatever you’re
    0:14:43 trying to amplify.
    0:14:44 This is an RNA virus.
    0:14:49 So you’re trying to bind it with a sequence that you know belongs to that virus.
    0:14:52 You attach it, it’s about 20 bases in length.
    0:14:56 You use the polymerase chain reaction to extend out that 20 base primer to cover the entire
    0:15:00 sequence or whatever like piece of the sequence that you’re trying to amplify.
    0:15:02 And then you get many, many copies this way.
    0:15:04 What does that give you having the many, many copies?
    0:15:05 Surveillance or absence, right?
    0:15:08 So, and amounts, it’s called real time PCR.
    0:15:09 I actually don’t love the name.
    0:15:14 I think QPCR is a better name for this quantitative PCR because it’s telling you how many pieces
    0:15:18 of essentially like what is the viral load in the bloodstream or the load of whatever
    0:15:20 pathogen you’re looking for.
    0:15:24 So Keith Robison, who’s currently principal scientist at Ginkgo wrote about, you know,
    0:15:25 how some of these tests work.
    0:15:30 And he basically agrees with you that it should be called QPCR because as you note, what you’re
    0:15:31 basically describing as it’s quantitative.
    0:15:32 Yeah.
    0:15:33 And real time doesn’t really mean much.
    0:15:38 But there’s another critical reason why people don’t like RT-PCR is because there’s a completely
    0:15:41 different concept that is called reverse transcriptase PCR.
    0:15:44 That’s why it’s kind of hard to talk about this with this virus because it’s an RNA virus.
    0:15:45 Right.
    0:15:48 In fact, he also talks about the fact that PCR works with DNA.
    0:15:52 But yet you’re telling me coronavirus is RNA, so can you help explain that distinction?
    0:15:53 Absolutely.
    0:15:58 So in this reaction, what you’re doing is using a polymerase that is used to binding either
    0:16:00 DNA or RNA and then extending it.
    0:16:04 So in the case of the RNA viruses, you need the reverse transcriptase.
    0:16:10 So this is a weirdo polymerase that binds RNA templates and then extends and produces
    0:16:11 DNA.
    0:16:13 And the reason that you want DNA is that it’s really stable.
    0:16:15 We have a ton of ways to measure it.
    0:16:17 RNA is a little bit more fickle.
    0:16:23 So if you can turn this RNA signature, this RNA message into a DNA output that actually
    0:16:26 substantially simplifies downstream processing.
    0:16:30 So this reverse transcriptase piece is what is doing the RNA to DNA translation.
    0:16:31 Okay.
    0:16:33 So we’ve talked about what’s going on in the test.
    0:16:36 Let’s quickly talk about some of the differences from what we last talked about.
    0:16:41 We talked about R0 last time, which is really practically how many people, a newly infected
    0:16:46 person is likely to pass a virus on to and you explained what variables go into it.
    0:16:48 What is your take on where we are with the R0?
    0:16:49 Yeah.
    0:16:52 We just talked about the spike, the definition of what this disease is.
    0:16:55 Is it the viral load or is it like these symptoms?
    0:16:56 That’s changing as well.
    0:16:59 So I still think it’s too early to calculate an R0.
    0:17:04 There’s still a ton of cases out there that are not showing symptoms, so we can’t really
    0:17:06 calculate the number of people who have gotten infected.
    0:17:11 I think we have technically approached the point where it is a pandemic, although the
    0:17:13 definition for pandemic is quite loose.
    0:17:17 The World Health Organization defines it as a worldwide spread of a new disease.
    0:17:21 The Centers for Disease Control and Prevention, the CDC and the U.S. have a bit looser of
    0:17:25 a definition describing as a disease that spreads across regions.
    0:17:29 And quote from the CDC website is the fact that this virus has caused illness, including
    0:17:35 illness resulting in death and sustained person-to-person spread in China is concerning.
    0:17:39 These factors meet two of the criteria of a pandemic.
    0:17:41 And by the way, people want to read an excellent piece.
    0:17:45 Helen Branswell, and I mentioned her in our last episode, has a great piece in stat news
    0:17:49 with the headline quote, “Undershining Pandemics, What They Mean, Don’t Mean, and What Comes
    0:17:51 Next with the Coronavirus.”
    0:17:53 From your take, why is it so freaking confusing?
    0:17:58 The term pandemic is not particularly useful in this case because it only tells you about
    0:17:59 the geographical spread.
    0:18:02 It’s not actually telling you about the danger of the disease.
    0:18:07 Like flu is a global pandemic annually, but the term doesn’t necessarily mean, you know,
    0:18:09 very fatal or spreads very fast.
    0:18:13 It just means it’s been into more than two geographies outside of its original origin.
    0:18:20 So if a flu is a pandemic, that’s also endemic in that it is in our population and circulates.
    0:18:22 Can you actually explain endemic?
    0:18:25 Because my understanding of the word comes from like understanding evolution and Darwin
    0:18:28 and knowing about endemic species and the Galapagos.
    0:18:29 Yeah.
    0:18:30 What does that mean?
    0:18:32 So endemic is a more useful term than pandemic.
    0:18:37 It’s something that is going to live in a latent way in the population or in the environment.
    0:18:41 We should see a returning flu as the quintessential example of this.
    0:18:45 It’s still an open question as to whether this coronavirus is going to become endemic.
    0:18:46 Okay.
    0:18:49 So that’s the difference between pandemics, endemic, and add one more name to the list,
    0:18:50 which is misinfodemic.
    0:18:56 I’ve read a lot of people describing this potentially as an infodemic because of the
    0:19:00 spread of some fantastic rapid science, which you talked about last time, but there’s also
    0:19:03 a spread of misinformation as well.
    0:19:05 And so the two of these things are going hand in hand.
    0:19:08 There’s a group that has already published an epidemiological model of what they expect
    0:19:09 the spread to be.
    0:19:15 Again, if any of the data that’s going into there is either intentionally falsified or
    0:19:17 it is just too early.
    0:19:18 Incomplete.
    0:19:19 We don’t have good enough data.
    0:19:21 Or like the measurements have changed, right?
    0:19:26 So in the middle of last week, the way that Chinese hospitals were measuring cases changed.
    0:19:29 So that’s going to mess up the data pretty substantially.
    0:19:33 So I think that these models are going to suffer if garbage in, garbage out.
    0:19:35 If this infodemic issue continues.
    0:19:36 Okay.
    0:19:40 So beyond the numbers and the definition, let’s quickly talk about some of the weightings.
    0:19:44 According to the World Health Organization, some of the data from China last before this
    0:19:50 big spike suggested that 82% of confirmed cases have only mild infection.
    0:19:56 About 15% are severe enough to require hospital care and about 3% need intensive care.
    0:19:59 And then preliminary data suggested that roughly 2% of the people who tested positive for the
    0:20:00 virus have died.
    0:20:05 And that’s important because last time we reported the CFR, the case fatality rates,
    0:20:07 which for SARS was at 10%.
    0:20:14 And for MERS, it was actually 37% in Saudi Arabia, but 34% outside of that region.
    0:20:18 So last time you talked about the paradox between deadliness and the R0.
    0:20:20 What’s your updates, if any, on that?
    0:20:25 So the reason for that is that you can’t really have a high fatality rate and a fast
    0:20:26 spreading virus.
    0:20:30 Basically, dead people can’t spread the disease and people who are, you know, confined to
    0:20:32 their beds also can’t spread the disease as fast.
    0:20:35 But there’s another variable, which is incubation time.
    0:20:41 So this is the length of time that it takes for the infection to demonstrate some symptoms.
    0:20:44 And there’s a different period of time that’s called the latent period, which is the time
    0:20:49 between getting infected and becoming infectious.
    0:20:50 So these are two different variables.
    0:20:52 And these interplay in a really interesting way.
    0:20:56 If the latent time is really short, so you are infectious almost as soon as you’ve been
    0:21:00 infected, but the incubation time is long, you have no idea that you’re infected.
    0:21:02 You have no symptoms.
    0:21:05 You feel completely normal, but it turns out that you’re actually spreading the virus.
    0:21:10 So in that case, this sort of paradox between the case fatality and the spread rate is going
    0:21:14 to break because you can start spreading without actually having symptoms.
    0:21:18 It’s also probably too early to tell what the exact incubation period is going to be.
    0:21:22 Most estimates I’ve seen have topped out at about 14 days, but that’s still pretty long.
    0:21:25 So it’s something to definitely take into consideration.
    0:21:26 Okay.
    0:21:30 So bottom line it for me, where are we now in the situation update from the news and
    0:21:31 your perspective?
    0:21:35 So the bottom line is it’s still too early to put hard numbers on any of these facts.
    0:21:40 It’s important to keep track of where the cases are coming up, where they’re being reported,
    0:21:44 and don’t jump to any conclusions about case fatality rates, about R knots, because it’s
    0:21:46 just too early.
    0:21:49 Other than that, the same precautions apply.
    0:21:50 Thank you for joining the segment.

    This episode covers the following — since our previous deep-dive on the novel coronavirus outbreak — including:

    1. practical implications for the U.S. healthcare system given how it works today, and where we might go in the future — with a16z general partner Julie Yoo, given our vantage point in tech; and
    2. how the rt-PCR test works — with a16z bio partner Judy Savitskaya;

    …in conversation with Sonal Chokshi.

    Sources for updates at top:

    Sources for last week’s episode:

    image: CDC test kit for COVID-19/ Wikimedia Commons 

  • Metrics and Mindsets for Retention & Engagement

    AI transcript
    0:00:05 The content here is for informational purposes only, should not be taken as legal business
    0:00:10 tax or investment advice or be used to evaluate any investment or security and is not directed
    0:00:15 at any investors or potential investors in any A16Z fund. For more details, please see
    0:00:21 A16Z.com/disclosures. Hi, everyone. It’s Marketplaces Week over here. Thanks
    0:00:26 to our consumer team releasing a new index of the next industry-defining marketplaces.
    0:00:32 You can check that out at A16Z.com/marketplace100. But what happens as such marketplaces and other
    0:00:38 platforms and products evolve over time as do their users? The conversation that follows
    0:00:41 is one of our more popular episodes from a couple years ago, featuring general partners
    0:00:47 Andrew Chen and Jeff Jordan in conversation with me on how after you acquire users, which
    0:00:52 we covered in another episode, then how do you keep them engaged, retain them, and even
    0:00:58 resurrect or re-engage them and what are the key metrics? But first, we began with what
    0:01:02 happens after the initial acquisition as different kinds of users join a product or
    0:01:07 platform over time. What does that mean for engagement and where do cohort analyses come
    0:01:08 in?
    0:01:12 One of the things that you see is that people end up using these products very differently
    0:01:17 because the kinds of users that you’re getting are changing over time. When you look at something
    0:01:24 like rideshare, all the early cohorts are basically people in urban areas. These days,
    0:01:29 all of rideshare is more like suburban or rural folks because you’ve saturated all of
    0:01:36 the center. What you tend to see is as you acquire your core demographic out, that actually
    0:01:42 ends up showing up in the engagement. Going back to natural gravity to the whole thing,
    0:01:46 because gravity also hits the engagement side of things as well, and then ultimately the
    0:01:52 LTV because your users are typically getting less valuable. It may take years to see this
    0:01:56 kind of play out, but that’s kind of the natural law of things.
    0:01:59 There is a progression in these and particularly the ones that are really successful. Early
    0:02:04 on, it’s all about getting users. Just like users, users, users. If you’re wildly successful
    0:02:10 at doing that, you run out of users or you start running low on users and you have to
    0:02:15 go to engagement. Pinterest has a very high quality problem right now. Most women in
    0:02:18 America have downloaded the Pinterest app.
    0:02:20 Oh yeah, I’ve had it for years.
    0:02:24 Some growth can come through, okay, there are some number of women who’ve never heard of
    0:02:28 Pinterest somewhere in the country, but much more so, they need to engage and re-engage
    0:02:33 the existing audience. I mean, we love engagement from an investor standpoint because it’s just
    0:02:34
    0:02:36 It shows stickiness.
    0:02:40 You can often hack your way into new users. It’s really hard to hack your way into true
    0:02:41 engagement.
    0:02:42 Keeping them.
    0:02:47 If someone’s spending 20 minutes a day on your site, Pinterest and OfferUp, the major
    0:02:53 investment thesis was, “Oh my God, look at that engagement kind of thing.” If they can
    0:02:55 scale the user base, it’s a beautiful deal.
    0:02:59 What we mean by engagement is actually interacting with them and seeing their activity because
    0:03:05 to Andrew’s three points of acquisition engagement retention, the third piece is keeping them.
    0:03:10 The way that we’ll often analyze this is looking at cohort analyses where we’ll look at each
    0:03:15 batch of users that’s joining in each week and really start to dissect, “Well, how active
    0:03:16 are they really?”
    0:03:22 To compare all these cohorts over time, you’re basically putting the users that come in from
    0:03:27 a particular time frame, let’s say it’s a week, and you’re putting them into a bucket.
    0:03:31 What you’re doing is you want to compare all of these different buckets against each other.
    0:03:36 What you typically do is you look at a bucket of a cohort of users and you say, “Okay, well,
    0:03:40 once they’ve signed up, the week after, how active are they? What about the week after
    0:03:44 that and the week after that and you can build out a curve?” It just turns out that these
    0:03:49 curves, once you’ve looked at enough of them, surprisingly, human nature, they all look
    0:03:50 kind of the same.
    0:03:51 I bet.
    0:03:55 They kind of all kind of curve down and for the good ones, they start to flatten out and
    0:03:59 they plateau and then for the really good ones, they’ll actually swing back up and people
    0:04:01 will come back to the surface.
    0:04:06 What you want to do is you want to compare the various cohorts against each other in
    0:04:13 time to see if you can spot any trends on how the usage patterns are increasing or decreasing.
    0:04:18 When you add a new layer to layer cake, you might unlock a bunch of new behavior.
    0:04:22 You might unlock a bunch of new frequency that didn’t exist before or alternatively,
    0:04:27 over long thresholds of time, people tend to become less active as you move out of your
    0:04:28 course.
    0:04:29 The cohort graduates.
    0:04:33 If not, a specific cohort of users flattens out is really important because if you’re
    0:04:37 in a world where they slowly degrades and then all of a sudden it’ll actually go to
    0:04:42 zero, that means that you’re naturally always filling up the bucket.
    0:04:43 You kind of have a leaky bucket.
    0:04:44 You’re constantly filling it out.
    0:04:45 You’re always filling it up.
    0:04:46 Right?
    0:04:51 What happens is that gets progressively harder if you want to keep your overall growth rate
    0:04:57 because that means you have to double, triple, quadruple your acquisition in order to counteract
    0:04:58 for that.
    0:05:03 That growth accounting equation that’s often thrown around is that your net MAUs, so your
    0:05:09 net monthly active users, equals all the new people that you’re acquiring, right, minus
    0:05:14 all the people that are churned, right, and then plus all the people that you’re resurrecting,
    0:05:15 you know.
    0:05:16 Reengaging.
    0:05:17 Reengaging, exactly.
    0:05:18 Right.
    0:05:19 That are coming back after they’ve churned.
    0:05:23 And so what happens is for a new startup, you are completely focused on new users because
    0:05:26 you don’t really have that many users to churn.
    0:05:30 And over time, as you get bigger and bigger and bigger, what you find is that your churn
    0:05:33 rate starts to, you know, it’s a percentage of your actives.
    0:05:37 And so, you know, the evolution of most of these companies as they’re getting bigger
    0:05:43 tends to start with acquisition, then focus much more on, you know, churn and retention,
    0:05:47 and then ultimately also to layer in resurrection as well.
    0:05:50 And the cohort curves have a couple other features that I love.
    0:05:56 And usually in marketplace businesses, the best models are built off of the cohort curves.
    0:05:57 Oh, interesting.
    0:06:00 Because you have to understand that degradation and where it goes.
    0:06:03 Using cohorts really give you a sense of, are there network effects?
    0:06:07 And network effect is the business gets more valuable, the more users that use it.
    0:06:12 If it gets more valuable, your newer cohorts should behave better than your early cohorts.
    0:06:13 Why is that?
    0:06:16 Because the service is more valuable given how many there are.
    0:06:17 Oh, interesting.
    0:06:18 So that’s kind of a tip.
    0:06:19 I get that.
    0:06:22 If you’re going to get more restaurants, you’re going to get a whole lot more reservations
    0:06:25 per diner because you are serving more than you need.
    0:06:30 So the open table cohorts would climb up and get more attractive over time.
    0:06:34 Versus, you know, we talked about typically they tended to grade over time.
    0:06:38 If you’ve reversed the polarity and they’re growing over time, it means you’ve made the
    0:06:41 business more valuable and then you start projecting forward.
    0:06:44 Okay, what a better way to know the business is actually more valuable than thinking is
    0:06:46 valuable and bleeding your own mind.
    0:06:50 And in network effects business, we always ask, show us the cohorts.
    0:06:52 Everyone asserts, I’m a network effect.
    0:06:53 I’m a network effect.
    0:07:00 But when you say show me the data, cohort curves, or they don’t lie, they don’t lie.
    0:07:02 The other really interesting part is segmenting it.
    0:07:04 I was about to actually ask you what are the buckets of cohorts?
    0:07:06 Are they all demographic data?
    0:07:10 For a bunch of hyper-local type businesses, the reason why segmenting it based on market
    0:07:15 geography, why that’s so valuable is because then you can compare markets against each
    0:07:16 other.
    0:07:19 You can say, well, you know, this market which has much more density in terms of the number
    0:07:23 of scooters behaves like this, and you can start to draw conclusions, you know, sort
    0:07:26 of a natural A/B test in order to do that.
    0:07:30 And I think the similar kind of analysis you can do for B2B companies is for products that
    0:07:33 have different size teams using it.
    0:07:37 If you have a really large team that are all using a product, well, are they all using
    0:07:39 the product more as a result?
    0:07:42 And let’s compare that to something that maybe only has a couple, right?
    0:07:45 And so this way, you can start to kind of disassemble, you know, the structure of these
    0:07:48 networks and do they actually lead to higher engagement?
    0:07:50 Slack would be a perfect example of that.
    0:07:54 You know, just if you have five people in the organization using Slack, you get one use
    0:07:55 curve.
    0:07:58 If you have, you know, if the organization, it’s the operating system for the organization,
    0:07:59 you have a very different curve.
    0:08:03 Though it’s not just an accident, you have to sort of architect it, not just expect like
    0:08:05 serendipity to fall into place.
    0:08:10 So after you get the new users, the way that you have to think about it is around quality,
    0:08:11 right?
    0:08:14 And you have to make sure that the new users turn into engaged users.
    0:08:17 One of the things people often talk about is just sort of this idea of like an aha
    0:08:22 moment or a magic moment where the user really understands the true value of the product.
    0:08:23 But often that involves a bunch of setup.
    0:08:27 So for example, for all the different social products, whether that’s Twitter or Facebook
    0:08:31 or Pinterest, et cetera, you have to make sure that when you first bring a new user
    0:08:36 and they have to follow all the right people, they have to get the onboarding experience.
    0:08:39 Which by the way, isn’t just signing up, but it’s actually, you know, doing all the
    0:08:45 things to get to this like, aha, where you’re like, oh, I get this product, it’s for me.
    0:08:49 And once you get that, then they’re kind of, then you have the opportunity to keep them
    0:08:51 in this engaged state over time.
    0:08:55 Is that really such a thing that there is like an aha moment or is it sort of like
    0:08:56 accumulative?
    0:08:59 A lot of the later users on Facebook came because everyone else was already there.
    0:09:01 Is this only tied to new users?
    0:09:05 In the case of Facebook, actually the fact that everyone was already there makes the
    0:09:07 aha moment that much more powerful, right?
    0:09:11 Because all your friends and family, they’re already there, your feed’s already full of
    0:09:12 content.
    0:09:15 And the first time that you see photos that maybe, you know, of someone that you went
    0:09:16 to high school with, right?
    0:09:17 Yeah.
    0:09:18 That’s actually what happened to me.
    0:09:20 I was so excited when I saw an old friend, right?
    0:09:21 Right.
    0:09:22 Yeah, exactly.
    0:09:25 And so what that means is like, you get the product and then afterwards, you know, when
    0:09:28 you actually are getting these push notifications or emails that are like, hey, it’s someone’s
    0:09:32 birthday or you know, whatever, like you’ve internalized what that product is.
    0:09:36 And you know, this moment is different for all sorts of different companies.
    0:09:39 I’ve always heard this referred to as the magic number.
    0:09:43 When you show up and it’s a blank slate, it’s like, what is this about?
    0:09:49 But they would drive you maniacally to, you know, follow people because that when you
    0:09:54 got to their magic number where they had statistically correlated the number of followers with long
    0:09:59 term engagement and retention, they would kill you to get you there doing what felt
    0:10:04 like a natural acts of like, yeah, you log on with follow and you say no and say, yes.
    0:10:10 But when they got you there, it kicked in and the service then quote unquote worked for
    0:10:11 you.
    0:10:13 A lot of the entrepreneurs I work with are trying to figure out what is my magic moment
    0:10:16 that then creates the awareness of the value problem.
    0:10:18 So take the example of Pinterest.
    0:10:21 Pinterest when it goes to a new market, first of all, they figure out they need a lot of
    0:10:23 local content to make it compelling to local users.
    0:10:29 The U.S. corpus of images doesn’t necessarily is helpful in international markets but isn’t
    0:10:30 sufficient.
    0:10:31 You’re right.
    0:10:35 Like, sorry, I don’t only want like skirts, you may not be able to wear in certain regions.
    0:10:36 Exactly.
    0:10:39 I haven’t worn a sorry in North America at a long time.
    0:10:44 But then once you have the content set, then you have to get compelling information to
    0:10:47 that individual in front of them, which, you know, you don’t know the individual when
    0:10:48 they walk in the door.
    0:10:52 The faster they do that, the more quickly, the better the business performs, engagement
    0:10:54 goes up, retention goes up and it works.
    0:10:58 So different entrepreneurs had to figure out what is that?
    0:11:01 What experience do they want to deliver where people get it?
    0:11:03 And then how do you engineer your way into delivering it?
    0:11:04 Okay.
    0:11:08 So they’ve kind of come up through acquisition and you’ve gotten new users.
    0:11:09 They get the product.
    0:11:13 You even have hopefully a way to measure that and see and track it over time.
    0:11:17 Do you want to then go into trying to get different users?
    0:11:18 Do you take your existing users?
    0:11:22 One of the things that we covered very early on is that with SaaS, you always want to try
    0:11:28 to take existing users and upsell them because it’s way more expensive to acquire a new customer
    0:11:29 in that context.
    0:11:30 I mean, of course, you want to grow your customers.
    0:11:32 How does this play out in this context?
    0:11:33 What happens next?
    0:11:34 A lot of companies is a progression.
    0:11:38 So almost all the early activity in the company is, okay, how do I get the users?
    0:11:44 As you get users, you get more and more leverage from efforts at activation and retention and
    0:11:45 engagement.
    0:11:46 So, use Pinterest as an example again.
    0:11:50 A very high percentage of women in America have downloaded Pinterest.
    0:11:56 Then the leverage quickly goes into, okay, how do I keep them engaged, reactivates the
    0:12:02 one who disappears and their acquisition efforts in the U.S. get de-emphasized and all the
    0:12:06 leverage is there, except as they’re going international, they’re still in that acquisition
    0:12:07 part of the curve.
    0:12:11 So, I think the leverage changes over time based on the situation in the company.
    0:12:16 Facebook hasn’t had any users in the U.S. forever because they have them all.
    0:12:19 This kind of goes back to this portfolio approach to thinking about your users.
    0:12:25 Once you have an active base of users and customers, what starts to get really interesting
    0:12:29 is to really analyze what are the things that actually set that group up to be successful,
    0:12:33 really long-term sticky users versus what are the behaviors and profiles where users
    0:12:34 aren’t successful, right?
    0:12:38 You actually throw your data science team on it to figure out all the different weights
    0:12:44 for both behavioral as well as the demographic and profile-based stuff on there.
    0:12:48 So, one of the first things that you figure out is that each one of these products actually
    0:12:55 has this ladder of engagement where oftentimes new users show up to do something that’s
    0:13:00 valuable but potentially infrequent, and you need to actually level them up to something
    0:13:02 that happens all the time.
    0:13:06 For example, when you first install Dropbox, the easiest thing that you can do is you can
    0:13:10 use it to just sync your home and your work computers, right?
    0:13:15 And that’s great, but really the way to get those users to become really valuable is for
    0:13:18 them to start sharing folders at work with their colleagues.
    0:13:22 Because once they have that and people are dragging files in, they’re really starting
    0:13:25 to collaborate on things, that’s like the next level of value that you can actually
    0:13:30 have on a daily basis versus this thing that is in the background that’s just syncing
    0:13:31 your storage.
    0:13:34 So, what are some of the things that people can then do to move those users up that ladder
    0:13:35 of engagement?
    0:13:40 Step one is really segmenting your users into this kind of engagement map.
    0:13:45 Oftentimes, you’ll see this visualized as a kind of state machine where you have folks
    0:13:48 that are new, you have folks that are casual, and you want to track how much they’re moving
    0:13:51 up or down in each one of these steps.
    0:13:53 And then once you have that, then the question is, okay, well, great, how do you actually
    0:13:55 get them to move from one place to the other?
    0:13:57 First, there’s content and education.
    0:14:01 They need to know in context that they can actually do something.
    0:14:06 So, for example, if you can get your users to set their home and work for a transportation
    0:14:11 product, then you can maybe figure out, okay, should I prompt them in the morning to try
    0:14:13 their ride based on what the ETAs are, right?
    0:14:15 Like, in the app, there would be some kind of notification.
    0:14:17 Like, life cycle messaging factor in there.
    0:14:21 The second is, of course, if your product has some kind of monetary component, then you
    0:14:23 can use incentives 10 bucks off.
    0:14:27 Your next subscription, if you do this behavior that we know for sure, gets you kind of to
    0:14:28 the next step.
    0:14:32 And then the third thing is really just refining the product for that particular use case.
    0:14:36 But maybe there are certain kinds of products that are transacted all the time, and so you
    0:14:41 maybe want to waive fees or give some credits or you do something in order to get people
    0:14:43 to kind of get addicted to that as a thing.
    0:14:47 And a really interesting thing is the frequency with which something’s consumed.
    0:14:53 I mean, eBay had enormous levels of engagement early on for a commerce app in particular.
    0:14:57 People would spend hours just browsing because early on it was about collectibles and it
    0:14:58 was about people’s passion.
    0:15:04 So if someone’s passionate about depression or glass, they will spend hours if you give
    0:15:08 them that depth of content to say, “Oh my God, I just found the perfect item.”
    0:15:11 Open table and Airbnb are both typically much more episodic.
    0:15:14 Most people don’t dine at fine dining restaurants with high frequency.
    0:15:18 Our median user dined twice a year on open table.
    0:15:22 And so that has completely different marketing implications and user implications.
    0:15:26 Measurement’s probably even more important in the engagement retention thing because
    0:15:32 we got our data scientists to understand the different consumer journeys through our product.
    0:15:38 And then we tried to develop tactics to accelerate the journeys we wanted and limit the journeys
    0:15:39 we don’t want.
    0:15:44 But in order to develop your strategy, you really need to understand how your users are
    0:15:47 behaving at a really refined level.
    0:15:49 So what are some of the engagement metrics?
    0:15:51 One really important area is frequency.
    0:15:55 Just how often are you using the product regardless of the intensity and the length of the sessions
    0:15:58 and all that other stuff, you know, just literally just frequency of sessions.
    0:16:04 We might often ask for a daily active user divided by monthly active user ratio.
    0:16:07 And that gives you a sense for like how many days is a user active.
    0:16:08 Doubt them out.
    0:16:13 You recently put a post out on the DAU/MAU metric.
    0:16:17 And when it works and when it doesn’t, there’s a lot of nuances around when to apply it and
    0:16:18 when not to.
    0:16:22 DAU/MAU was very much popularized by the fact that Facebook used it, including in their
    0:16:24 public financial statements.
    0:16:27 And it really makes sense for them because they’re an advertising business and it matters
    0:16:30 a lot that people use them a lot all the time, right?
    0:16:31 Right.
    0:16:34 It’s like counting impressions and being able to sell that to advertisers, right?
    0:16:35 Exactly.
    0:16:39 And they have historically been 60% plus daily actives over monthly actives.
    0:16:40 And that’s very high.
    0:16:44 You know, you’re using it more than half the days in a month.
    0:16:48 On the flip side, what I was talking about in my essay about this is that DAU/MAU can
    0:16:51 tell you if something’s really high frequency and if it’s working.
    0:16:55 But a lot of times products are actually lower DAU/MAU for a very good reason because they’re
    0:16:58 sort of just a natural cadence, you know, to the product.
    0:17:02 Like you’re not going to get somebody who is using a travel product to use it more than
    0:17:04 a couple of times per year.
    0:17:07 And yet there are many valuable travel companies, obviously.
    0:17:09 So you’re saying don’t live and die by that alone.
    0:17:10 Exactly, right.
    0:17:13 Because it really depends on the product you have, the type of nature of use that it has,
    0:17:14 et cetera.
    0:17:18 You just want to make sure that the metric reflects whatever strategy that you’re putting
    0:17:19 in place.
    0:17:22 If you think that your product is a daily use product and you’re going to monetize using,
    0:17:25 you know, a little bit of money that you’re making over a long period of time, but your
    0:17:30 DAU/MAU is low, is like sub 15%, then like it’s probably not going to work.
    0:17:35 And then a metric called L28, which is something else that was pioneered certainly early at
    0:17:36 Facebook.
    0:17:37 And it’s a histogram.
    0:17:38 And what you want to do is…
    0:17:40 And a histogram is a frequency diagram.
    0:17:41 Right.
    0:17:45 A frequency diagram that basically says, okay, you know, show a bar showing how many users
    0:17:50 have visited once in that month, then twice in the month, and then three times in the
    0:17:52 month, and then four times in the month, and you kind of build that all the way out to
    0:17:53 28 days.
    0:17:55 Because there’s 28 days in the month on average, right?
    0:17:57 And the 28 days is to remove seasonality.
    0:18:00 And then related one obviously is like L7, right?
    0:18:01 So just like last seven days.
    0:18:02 And so what you want to see…
    0:18:04 You don’t want to see wows, weekly, active users.
    0:18:05 Is that really a thing, by the way?
    0:18:06 Am I just making that up?
    0:18:07 Right.
    0:18:08 Yeah, wow.
    0:18:09 That was over a while ago.
    0:18:10 You just coined it.
    0:18:11 No, great.
    0:18:12 I’m not reclaiming retainment.
    0:18:13 Why not?
    0:18:14 Right.
    0:18:17 And so the idea with, you know, an L28 or an L7 is the idea that you should actually
    0:18:23 start to see when you graph this out that there’s a group of people who just use it 28
    0:18:25 days out of 28 days, right?
    0:18:29 And that there’s a big group of people who use it 27 days out of 28 days, right?
    0:18:30 And that there’s a big cluster.
    0:18:33 And so that’s how you know that you actually have a hardcore segment.
    0:18:38 And that’s really important because in all these products you typically have a core part
    0:18:41 of the network that’s driving the rest of it, whether that’s power sellers or power
    0:18:45 buyers or, you know, in a social network, the creators versus the consumers.
    0:18:49 Actually, I’ve heard this referred to as the smile because the one use is always pretty
    0:18:50 big.
    0:18:51 A lot of people show up once.
    0:18:53 I don’t understand what this is and disappear.
    0:18:54 So that’s the one.
    0:18:57 And then they typically slide down more people use it.
    0:19:03 Fewer people use it two days in one, three days in two, done right, it starts to increase
    0:19:04 at the end.
    0:19:06 So you basically get a smile, you just go down.
    0:19:08 And I mean, that’s really powerful.
    0:19:10 Facebook had a smile.
    0:19:12 WhatsApp had a smile.
    0:19:13 Instagram had a smile.
    0:19:18 If you take a step back, it’s a precondition for investing in a venture business essentially
    0:19:19 that there’s growth.
    0:19:24 If it didn’t market and then you want to see growth, but growth by itself is not sufficient.
    0:19:26 Investors love engagement.
    0:19:31 So Pinterest, the key driver of Pinterest, it was growing, but the users were using it
    0:19:32 maniacally.
    0:19:33 Oh my God.
    0:19:36 I think I spent an entire Thanksgiving using Pinterest.
    0:19:41 Was the engagement that blew my mind much more than the growth offer up has engagement
    0:19:45 that’s similar to social sites like Instagram and Snap.
    0:19:50 I mean, a commerce site, mobile classifieds, people just sit there in troll looking for
    0:19:55 marketers.
    0:19:59 So Datamow, Smile, all these metrics are so core to us because a big engaged audience
    0:20:01 is so rare.
    0:20:04 And as a result, it’s almost always incredibly valuable.
    0:20:07 And the engagement ends up being very related to acquisition.
    0:20:11 Because when you look at all the different acquisition loops, whether it’s paid marketing
    0:20:15 or a viral loop or whatever, all of those things are actually powered by engagement
    0:20:16 ultimately.
    0:20:21 We need people to get excited about a product in order to share content off of that platform
    0:20:24 to other platforms in order to get a viral loop going.
    0:20:30 And so one of the things I was going to also add on Daumau and L28 is that they’re actually
    0:20:31 really hard to game, right?
    0:20:32 Which is fascinating.
    0:20:36 Whereas growth can be very easy to game.
    0:20:37 Right.
    0:20:38 Exactly.
    0:20:39 Yeah.
    0:20:40 Why is that?
    0:20:41 What’s the difference?
    0:20:42 The typical approach is to say, well, I’m going to add an email notifications.
    0:20:43 I’m going to do more push notifications.
    0:20:44 I’m going to do more of this and that.
    0:20:48 And then automatically, you know, these metrics ought to go up, right?
    0:20:53 The challenging thing is actually usually sending out more notifications will actually
    0:20:56 cause more of your casual users to show up because your hardcore users were already kind
    0:20:58 of showing up, you know, already.
    0:21:03 And what that does is that’ll increase your monthly actives number, but actually not
    0:21:05 increase your daily actives as much.
    0:21:10 So I’ve actually seen cases where sending out more email decreases your Daumau as opposed
    0:21:11 to increasing it.
    0:21:12 That’s really interesting.
    0:21:16 When you think about this portfolio of metrics, it really tells you a story about people are
    0:21:18 kind of coming but not really staying.
    0:21:22 If you get an email or push notification every day, eventually you turn them off and then
    0:21:23 you just stop.
    0:21:27 So then you get counted as a male for that period of time and then, you know, you lose
    0:21:28 them as it out.
    0:21:31 Acquisition is super easy to game because you can just spend money.
    0:21:35 Or you got a distribution hack that works early on in the Facebook platform.
    0:21:40 Companies literally got to a million users and it felt like minutes just because there
    0:21:46 were so many people on Facebook and the ones who were early just got exploding user bases.
    0:21:50 There were a number of concepts whose mean number of visits was one.
    0:21:51 They never came back.
    0:21:56 So you get to see these incredibly seductive growth curves, but our job is essentially
    0:22:01 to be cynical and just say, okay, we need to go below that because there are a lot of
    0:22:03 talented growth hackers who can drive growth.
    0:22:08 I looked at a number of businesses that tens of millions of users and no one ever came
    0:22:09 back.
    0:22:11 Engagement is so, so key.
    0:22:14 So we’ve talked especially about the fact that growth and network effects are not the
    0:22:18 exact same thing because network effects by definition are that a network becomes more
    0:22:21 valuable the more users that use it.
    0:22:23 What happens on the engagement side with network effects?
    0:22:26 What are the things we should be thinking about in that context?
    0:22:30 Typically network effects, if they’re real, manifest in data.
    0:22:33 Things like the cohort curves improve over time.
    0:22:35 Usually there’s a decay with network effects.
    0:22:39 There often is a reversal where they’re growing because it’s more valuable.
    0:22:40 Their smile essentially.
    0:22:44 My diligence at OpenTable was I looked at San Francisco, which was their first market
    0:22:50 and sales rep productivity grew over time, restaurant churn decreased over time.
    0:22:52 The number of diners per restaurant increased over time.
    0:22:56 The percentage that booked through OpenTable versus the restaurant’s own website moved
    0:23:00 towards OpenTable dramatically, every metric improved.
    0:23:04 And so, you know, that’s where it both drives good engagement, but also it just improves
    0:23:05 the investment basis.
    0:23:06 The value overall, right?
    0:23:11 The interesting points about network effects is that we often talk about it as if it’s
    0:23:12 a binary thing.
    0:23:13 Right.
    0:23:14 Or homogenous.
    0:23:15 Like all network effects are equal when they’re not.
    0:23:16 Exactly, right.
    0:23:18 When you look at the data, what you really figure out is network effect is actually like
    0:23:22 a curve and it’s not like a binary yes/no kind of thing.
    0:23:27 So, you know, for example, I would guess that if you plotted the number, if you took a bunch
    0:23:32 of cities, every city was a data point and you graphed on one side the number of restaurants
    0:23:36 in the city versus the conversion rate for that city.
    0:23:39 You would quickly find that when cities have more restaurants, the conversion rate is higher,
    0:23:40 right?
    0:23:41 I’m just guessing.
    0:23:43 It’s almost perfect with one refinement.
    0:23:47 The number of restaurants you have is a percent of that market’s restaurant universe.
    0:23:48 Okay, right.
    0:23:50 Because having a hundred restaurants in Des Moines is different than having a hundred
    0:23:51 restaurants in Manhattan.
    0:23:52 Makes total sense.
    0:23:57 So, not only that, what you then quickly figure out is that there’s some kind of a diminishing
    0:24:00 effect to these things often in many cases.
    0:24:05 So, for example, in rideshare, if you are going to get a car called 15 minutes versus
    0:24:07 10 minutes, that’s very meaningful.
    0:24:11 But if it’s, you know, five minutes versus two minutes, your conversion rate doesn’t
    0:24:12 actually go up.
    0:24:16 If you can express your network effect in this kind of a manner, then what you can start
    0:24:21 to show is, okay, yeah, we have a couple new investment markets that maybe, you know,
    0:24:24 don’t have as many restaurants or don’t have as many cars.
    0:24:29 But if we put money into them and invest in them and build the right products, et cetera,
    0:24:30 then you can grow.
    0:24:34 You can do this kind of same analysis, whether you’re talking about, you know, YouTube channels
    0:24:37 and the number of subscribers you might have.
    0:24:38 Having more videos is better.
    0:24:39 I’m sure you can show that.
    0:24:43 If you go into the workplace and you start thinking about collaboration tools, then what
    0:24:50 you ought to see is that as more people use your chat platform or your collaborative document
    0:24:53 editing platform, then the engagement on that is going to be higher.
    0:24:56 And you should be able to show that in the data by comparing a whole bunch of different
    0:24:57 teams.
    0:25:01 Okay, so we’ve talked about engagement and also how it applies to network effects.
    0:25:04 Are engagement and retention the same thing?
    0:25:06 I mean, in all honesty, they sound like they would be the same thing.
    0:25:07 There’s overlap.
    0:25:08 Yeah, there’s overlap.
    0:25:09 Yeah.
    0:25:10 Just to give a couple examples.
    0:25:14 So weather is low frequency, but high retention because like, you’re actually going to need
    0:25:15 to know what the weather is.
    0:25:16 Only once a day.
    0:25:17 You know, yeah.
    0:25:19 Unless you live in San Francisco, you got to check it like 20 times a day with all the
    0:25:20 network.
    0:25:21 Right, exactly.
    0:25:22 Or if you live down here, you have to check it twice a year.
    0:25:23 That’s true.
    0:25:24 It’s actually the same year around.
    0:25:28 That’s actually what it showed was actually more that generally people didn’t really check
    0:25:29 it that often.
    0:25:33 However, we were highly likely to have it installed and running after 90 days because
    0:25:34 that’s, it’s a reference thing.
    0:25:35 It’s so important.
    0:25:36 Yeah.
    0:25:41 Versus if you look at something like games or ebooks or, you know, those kinds of products,
    0:25:45 like really high engagement because you’re like, all right, I’m going to get to, I’m
    0:25:48 going to finish this like trashy science fiction novel that I’ve been reading.
    0:25:50 I’m just going to like get to it.
    0:25:53 But then as soon as you’re done, you’re like, okay, there’s no reason why I would go back
    0:25:54 and read it again.
    0:25:58 So the real difference is that engagement obviously varies depending on the product.
    0:26:02 The type of thing it is, whether it’s a weather or ebook and retention is, are you still using
    0:26:04 it after X amount of time?
    0:26:06 And different companies have different cadences.
    0:26:12 If the average users twice a year retention is, did they book annually other businesses
    0:26:13 or did they come daily?
    0:26:17 But the model behind retention is completely different and the model behind engagement
    0:26:18 is completely different.
    0:26:19 Right.
    0:26:22 The chart that I’d love to really see is one that was a bunch of different categories
    0:26:26 that’s retention versus frequency versus monetization.
    0:26:30 And I think you got to be like really good at least on one of those axes.
    0:26:32 So we’ve done sort of this taxonomy of metrics.
    0:26:34 We’ve talked about the acquisition metrics.
    0:26:38 We’ve talked about some engagement metrics, primarily frequency and engagement.
    0:26:42 It’s also time, not just how frequent someone is, but just how much time do they spend,
    0:26:48 time spent on site, on the piece, writing comments, not just because I mean, the number
    0:26:52 of businesses that have great engagement is not high because they’re only so many minutes
    0:26:53 in the day.
    0:26:58 And so you’re just looking for where, okay, they’re just passing time and enjoying it.
    0:27:01 And they both have obvious monetization associated with that behavior.
    0:27:04 This is why Netflix is so freaking genius because when they literally invented the format
    0:27:08 of binge watching, which you could not do, which is, I love it because it’s a very internet
    0:27:09 native concept.
    0:27:11 I mean, they’ve literally fucked up everyone else’s engagement numbers.
    0:27:16 I think that’s one of the narratives on why building consumer products is much harder
    0:27:17 these days.
    0:27:18 And do you think it’s true or not?
    0:27:21 Well, because it used to be that you were, you know, what kind of time were you competing
    0:27:23 for in the first couple of years of the smartphone?
    0:27:26 You were competing against literally, I’m going to stare at the back of this person’s
    0:27:30 head, or I can like use some cool app that I’ve downloaded, right?
    0:27:34 Versus these days, you actually have to take minutes away from other products.
    0:27:35 Yes.
    0:27:40 And it’s typically other behemoths because the top apps are almost all done by Facebook,
    0:27:45 Amazon, Google, and, you know, breaking through just, Mark calls it the first page.
    0:27:50 The people who are on the first screen are just such the incumbents.
    0:27:54 And sure, most people have Facebook on the screen and YouTube on the screen and Amazon
    0:27:55 on the screen.
    0:28:01 You know, that competition is a big overhang right now in consumer investing because you
    0:28:03 have to displace someone’s minutes.
    0:28:06 Yeah, I would add one more layer to that, at least on the content side, which is I think
    0:28:09 a lot of people make a lot of category errors because they think they’re competing with
    0:28:11 like-minded players.
    0:28:14 And in fact, when it comes to things like content and attention, you’re competing with just
    0:28:15 about anything that grabs your attention.
    0:28:17 It’s not just other media outlets.
    0:28:18 It’s Tinder.
    0:28:19 It’s Tinder.
    0:28:20 It’s a dating app.
    0:28:21 It’s something else.
    0:28:26 I’m riding on the train for an hour. I could, you know, see one of my friends on our Facebook,
    0:28:27 watch videos on YouTube.
    0:28:28 Yeah, that actually changes the time blocks.
    0:28:31 Xerox Park did a really interesting study on micro-weighting moments, and they’re literally
    0:28:35 the little snatches of time, like two seconds here and there, that you might be weighting
    0:28:39 in line or doing something so you can do a lot of snack size things in that period, which
    0:28:41 is also another interesting thing to think about for how people engage with your business.
    0:28:45 So it’s actually funny because there’s some businesses that have good engagement where
    0:28:49 it’s one session that goes on for a while, YouTube or Netflix or something like that.
    0:28:55 There are others that are multiple small sessions at an aggregate because it’s the micro opportunities
    0:28:56 to.
    0:28:58 And Google is the best example of this, right?
    0:29:03 In fact, if you spend a lot of time on Google.com, you know, refining your searches and clicking
    0:29:05 around, that means actually the service is doing poorly.
    0:29:06 They failed.
    0:29:07 Interesting.
    0:29:10 Their goal is to get you to their advertisers as fast as they can.
    0:29:14 That’s a frequency play and a monetization play ultimately as opposed to an engagement
    0:29:15 one.
    0:29:16 Yes.
    0:29:17 That’s fascinating.
    0:29:18 And then some products are more on the engagement side.
    0:29:20 You have to optimize it based on how you’re monetizing it.
    0:29:22 What are some of the metrics for retention?
    0:29:24 I mean, is it just, should I stay or should I go?
    0:29:25 Is that the retention metric?
    0:29:29 And I think the big thing is the concept of churn is a tricky one.
    0:29:34 In some cases, like subscription, Hulu, Netflix, and then also in the SaaS world, whether or
    0:29:36 not you’re still continuing to pay or not, right?
    0:29:38 And that’s really obvious.
    0:29:41 The thing that’s tricky for a lot of these consumer products, especially episodic ones
    0:29:44 and it’s actually less whether they’ve quote unquote churned or not.
    0:29:47 It’s actually just whether or not they’re active or inactive and whether or not that’s
    0:29:52 happening at a rate that you in your business strategy have decided is acceptable or not.
    0:29:56 If every Halloween, you know how there’s those costume stores that like open all over the
    0:29:57 place.
    0:30:01 If every Halloween, you go back and you buy a costume, but you’re inactive the rest
    0:30:02 of the time.
    0:30:03 Have you churned or not?
    0:30:04 Like it’s not clear.
    0:30:07 And I would argue you’ve not churned because you’re doing exactly what they want, which
    0:30:09 is to buy a costume every Halloween.
    0:30:12 It seems like it makes assessing the retention of a consumer business very difficult.
    0:30:14 You adjust the time period that you’re relevant on it.
    0:30:20 If the average diner dines twice a year, so you can apply that metric travels a similar
    0:30:24 thing Airbnb is, you know, for the average user relatively infrequent, you have to tailor
    0:30:26 your look to what are they trying to do.
    0:30:30 So if you’re trying to stay up with your friends and you’re doing it twice a year, yeah, that
    0:30:31 doesn’t work.
    0:30:32 So Facebook has got a whole different center.
    0:30:36 One of the things that companies can often do is to measure upstream signal.
    0:30:40 So for example, Zillow, you’re probably not going to buy a house very often, right?
    0:30:43 Maybe, you know, a couple of times in your life.
    0:30:47 However, what’s really interesting is they can say, well, you know, maybe folks aren’t
    0:30:49 buying houses, but at least are we top of mind?
    0:30:52 Are they checking the houses that are going on sale in their neighborhood?
    0:30:53 Are they opening up the emails?
    0:30:55 Are they, you know, doing searches, right?
    0:30:57 Why do you call that upstream?
    0:30:58 In the funnel.
    0:31:01 You’re kind of going up in the funnel and you’re tracking those metrics as opposed to, you
    0:31:02 know, purchases.
    0:31:06 So even, you know, for open table, it’s like, okay, great, well, maybe if you’re not actually
    0:31:10 completing the reservations, are you at least checking the app for availability?
    0:31:12 What’s new restaurants where I want to dine there?
    0:31:16 There’s some level of content consumption throughout this entire episode.
    0:31:21 There seems to be this interesting dance between architecting and discovering like you might
    0:31:25 know some things upfront because you’re trying to be intentional and build these things.
    0:31:29 And then there are things that you discover along the way as your product and your views
    0:31:31 and your data evolves.
    0:31:34 How do you advise people to sort of navigate that dance?
    0:31:38 You iterate, you develop hypotheses, you put it out there and you test the hypothesis.
    0:31:41 You know, I think my product is going to behave this way and then did it.
    0:31:45 Probably the most important thing is for me, marketing can be art, marketing can be science.
    0:31:48 In the consumer internet, it’s more science.
    0:31:53 Some companies can effectively do TV campaigns, large media budgets, things like that.
    0:31:58 For me, the better companies typically just rip apart their metrics, understand the dynamics
    0:32:03 of their business and then figure out ways to improve the business through that knowledge.
    0:32:06 And that knowledge could feed back into new product executions or new marketing strategies
    0:32:08 or new something.
    0:32:13 This consideration, but it’s informed by the data at a level that, you know, on the best
    0:32:16 companies is really, really deep.
    0:32:23 Ultimately, you have a set of strategies that you’re trying to pursue and you pick the metrics
    0:32:26 to validate that you’re on the right track, right?
    0:32:29 And a lot of what we’ve talked about today has really been the idea that actually there’s
    0:32:32 a lot of nature versus nurture kind of parts about this.
    0:32:35 You know, your product could just be located in but high monetization.
    0:32:38 And so you shouldn’t look at, you know, DA/UMAU.
    0:32:41 And so you have to find really the right set of metrics that show that you’re providing
    0:32:46 value to your customers first and foremost, and then really, you know, build your team
    0:32:50 and your product roadmap and everything in order to reinforce that.
    0:32:54 Find the loops and the networks that exist within your product, because those are the
    0:32:58 things that are going to keep your engagement improving over time, even in the face of competition.
    0:32:59 Growth is good.
    0:33:02 Growth and engagement is really, really, really good.
    0:33:03 Okay.
    0:33:04 So that’s fabulous.
    0:33:05 Well, thank you guys for joining the A6NC podcast.

    It’s “Marketplaces Week” for us at a16z, thanks to our consumer team releasing a new index of the next industry-defining marketplaces, the Marketplace 100.  

    But what happens as such marketplaces and other platforms evolve over time, as do their users? This episode is a rerun of a popular conversation from a couple years ago — featuring general partners Andrew Chen and Jeff Jordan (in conversation with Sonal Chokshi) — on what comes after user acquisition: retention. 

    It’s all about engagement. So what are the key metrics? And if different kinds of users join a  platform over time — what does that mean for engagement, and where do cohort analyses come in?

  • Tough Love, Global Diplomacy, and Lessons on Leadership

    AI transcript
    0:00:04 – Hi everyone, welcome to the A16Z podcast.
    0:00:07 In today’s episode, A16Z General Partner Katie Hahn
    0:00:10 interviews Susan Rice, the former National Security Advisor
    0:00:12 and U.S. Ambassador to the UN.
    0:00:15 She’s the author of a memoir, “Tough Love.”
    0:00:16 This is a candid talk
    0:00:18 in which Ambassador Rice discusses leadership,
    0:00:20 what it is, how to achieve it,
    0:00:22 and how to focus under the extreme pressure
    0:00:23 of global crisis.
    0:00:26 She also talks about U.S. foreign relations
    0:00:28 and what role the tech community can play.
    0:00:29 This conversation took place
    0:00:31 at our most recent innovation conference,
    0:00:33 the A16Z Summit.
    0:00:35 It was previously released on YouTube
    0:00:36 if you’d like to check it out there.
    0:00:40 (audience applauding)
    0:00:43 – Susan, it’s so great to see you again here in LA.
    0:00:45 And this time I get to share you with this audience,
    0:00:47 which I’m really excited about.
    0:00:49 You’ve had such an incredible life
    0:00:51 and you’ve been in so many rooms and situations
    0:00:54 that really very few of us, even in this rarefied room,
    0:00:57 will ever really get to experience.
    0:01:00 Aside from being Obama’s national security advisor
    0:01:03 and the ambassador, the U.S. Ambassador to the United Nations,
    0:01:05 you were also the youngest assistant secretary
    0:01:07 of state in the Clinton administration.
    0:01:10 And you were a Rhodes Scholar.
    0:01:12 You have your doctorate from Oxford.
    0:01:14 And of course, all of these experiences
    0:01:16 meant that you had a front row seat
    0:01:19 to some pretty interesting situations,
    0:01:22 things like the Snowden Leaks, North Korea,
    0:01:25 negotiations with Iran,
    0:01:28 the war against ISIS, the Ukraine.
    0:01:31 And now you’re on the board of Netflix.
    0:01:32 You write for the New York Times
    0:01:35 and you’ve just published your memoir, “Tough Love.”
    0:01:37 So Susan, in “Tough Love,”
    0:01:40 you write that when you were in your younger years,
    0:01:43 when you were 32, people said about you
    0:01:46 that you were smart and dynamic and decisive.
    0:01:48 But they also said you were,
    0:01:52 and I quote, “Brash, demanding and impatient.”
    0:01:55 And I’m wondering if these traits are unbalanced.
    0:01:57 Do you think they were a bug or a feature
    0:01:59 as you rose through the ranks of the government?
    0:02:01 – Well, first of all, Katie,
    0:02:02 thank you so much for doing this.
    0:02:03 And good afternoon, everyone.
    0:02:05 It’s great to be with you.
    0:02:07 Thank you.
    0:02:14 I would say that I had a mix of qualities at age 32
    0:02:17 that were on the one hand feature and the other hand bug.
    0:02:22 On the feature side, I do think I had strong preparation.
    0:02:25 I was hungry, I was driving a team
    0:02:28 to a very particular set of outcomes.
    0:02:31 That was feature, but I was impatient.
    0:02:36 I was brash, and I think that I learned the hard way
    0:02:40 that I had to adjust some of those characteristics.
    0:02:42 They were more on the bug side
    0:02:47 and they were not well suited to the environment
    0:02:47 in which I was in.
    0:02:50 This was when I was a very young assistant secretary
    0:02:52 of state for African affairs.
    0:02:54 I’d started the job having worked
    0:02:56 at the White House previously.
    0:03:01 I was 32 years old and not only the youngest person
    0:03:06 by far among the people who worked with me and under me,
    0:03:09 but I was also the mother
    0:03:12 of a three-month-old breastfeeding son.
    0:03:15 And the combination of all of those things,
    0:03:18 plus my characteristics in the State Department,
    0:03:22 were, I think, off-putting to some.
    0:03:27 And I had a wonderful set of advisors and mentors,
    0:03:30 some of whom who took me to the woodshed
    0:03:33 and delivered a dose of tough love at a stage
    0:03:35 when it was very useful to me.
    0:03:36 – Yeah, and in particular,
    0:03:39 I know you write about several of those mentors in the book,
    0:03:41 but is there one that really exemplifies
    0:03:44 helping you overcome some of those,
    0:03:45 as you said, those characteristics
    0:03:48 that you’ve deemed were a bug?
    0:03:53 – Well, the most impactful experience was in 1998.
    0:03:57 I’d been in the job about a year.
    0:04:00 And 1998, none of you will recall,
    0:04:02 but I’ll remind you it was the year
    0:04:04 when not only on the African continent,
    0:04:08 we had wars break out between Ethiopia and Eritrea,
    0:04:13 huge war in the Congo, wars in West Africa as well.
    0:04:16 And over the summer in August,
    0:04:19 Al Qaeda attacked our embassies in Kenya and Tanzania
    0:04:24 and killed 12 Americans and over 200 Kenyans
    0:04:27 and left thousands wounded and our embassies destroyed.
    0:04:31 And so it was a really high pressure, high intensity time.
    0:04:35 And my approach to dealing with all of this
    0:04:38 was to keep focused on the mission,
    0:04:41 to drive through the pain,
    0:04:46 to just stay focused and push myself and the team
    0:04:48 as hard and as fast as we can
    0:04:50 to deal with all these simultaneous challenges.
    0:04:55 But just before Christmas, a colleague,
    0:04:56 a man named Howard Wolpe,
    0:04:59 who was a former member of Congress from Michigan
    0:05:01 and was working as a political appointee
    0:05:03 in the State Department,
    0:05:06 he took me out to lunch at a really crappy Chinese restaurant
    0:05:08 near the State Department.
    0:05:10 And I thought it was just gonna be a social occasion.
    0:05:13 And after a few bites, he came straight out
    0:05:17 and said, you know, Susan, you’re gonna fail in this job
    0:05:19 if you don’t change course.
    0:05:22 You’re smart, you’re committed, you know your brief,
    0:05:23 you’re hard charging,
    0:05:26 you’ve got the support of the Secretary of State
    0:05:27 and the President,
    0:05:32 but you are not being sufficiently deferential
    0:05:35 to sufficiently appreciative of the expertise
    0:05:38 of the senior people working with you.
    0:05:40 And you’re not bringing the team along,
    0:05:44 you’re not investing your team in the outcomes.
    0:05:47 You’re just driving relentlessly towards an outcome
    0:05:49 and you’re losing people.
    0:05:53 And if you don’t change course, you’re gonna fail.
    0:05:55 And I don’t wanna see you fail.
    0:05:57 And so we then had a conversation
    0:06:01 which was obviously pretty bracing for me,
    0:06:06 but I realized that he was doing this as a huge favor.
    0:06:08 He was doing this as somebody who cared.
    0:06:09 He could have basically said, you know,
    0:06:12 I don’t care if you fail, that’s not my problem.
    0:06:15 But he took me under his wing and gave me that advice
    0:06:17 which enabled me, I think,
    0:06:22 to be a far more patient, more inclusive,
    0:06:28 more collaborative leader and manager of teams
    0:06:30 than I had otherwise been.
    0:06:35 And that helped me soften some of those qualities
    0:06:37 that we described as a bug.
    0:06:39 And so that by the time I completed my tenure
    0:06:41 at the end of the Clinton administration,
    0:06:45 I think I really had learned and grown
    0:06:46 in ways that were very valuable.
    0:06:51 And I think I was able to leave behind a record of success
    0:06:53 without which I’m not sure I would be,
    0:06:55 have gone on to do the other things
    0:06:57 that I ended up doing in the Obama administration.
    0:06:59 – Well, one of the things that struck me
    0:07:01 in reading the book is you were so fortunate
    0:07:04 to have a number of mentors like that,
    0:07:05 including your own parents.
    0:07:06 And so I wanna take a step back
    0:07:08 and talk about your origin story
    0:07:10 because I’m sure a lot of people in this room
    0:07:12 are familiar with a lot of your accomplishments,
    0:07:15 but your parents were also really accomplished
    0:07:16 in their own right.
    0:07:19 I mean, your dad descended from slaves in South Carolina,
    0:07:22 went on to become a member of the Tuskegee Airmen.
    0:07:24 And then he went on also
    0:07:27 to become an economics professor at Cornell,
    0:07:30 eventually serving as governor of the Federal Reserve Bank
    0:07:33 and in several senior roles at Treasury and the World Bank.
    0:07:37 Your mom had a very different experience.
    0:07:40 She was the daughter of immigrants from Jamaica
    0:07:42 who settled in Maine,
    0:07:44 which explains your main connection.
    0:07:49 And she went on to Radcliffe, not only to Radcliffe,
    0:07:52 but also to become the student body president
    0:07:53 and then served on the boards
    0:07:57 of 11 different major public companies.
    0:07:59 Now, that seems, all of those things
    0:08:02 seem like really impressive accomplishments
    0:08:04 for any person at any time,
    0:08:08 but really rare, especially for a woman of color
    0:08:09 at that time.
    0:08:13 And so I’m just curious, what lessons did you take
    0:08:15 from these incredible parents you had?
    0:08:19 – Well, I really was blessed with two extraordinary parents
    0:08:23 who came, as Katie said, from extremely different backgrounds,
    0:08:25 but they had several things in common.
    0:08:27 They had a commitment to education,
    0:08:31 they had a commitment to service,
    0:08:36 and they had a sense that they had been blessed
    0:08:38 with the gifts of their parents and grandparents,
    0:08:41 and it was their responsibility to make the most of those,
    0:08:44 and the expectation for me and my brother
    0:08:45 was that we’d do the same.
    0:08:51 And as you said, their background’s very different,
    0:08:53 but on my father’s side,
    0:08:59 he grew up in really the most raw form of Jim Crow,
    0:09:05 and brutal segregation in South Carolina, born in 1920.
    0:09:08 And then, as you said, served at Tuskegee
    0:09:10 with the Tuskegee Airmen.
    0:09:14 And his challenge, as somebody whose parents
    0:09:18 and grandparents had both gone to college,
    0:09:21 his grandfather, my great grandfather, was a slave
    0:09:24 who ended up getting a college education
    0:09:28 after fighting in the Civil War on the side
    0:09:31 of the Union Army and founding a school in New Jersey
    0:09:34 that educated generations of African Americans.
    0:09:38 So there was a tradition on my father’s side
    0:09:43 of having the extraordinary opportunity to attend university,
    0:09:47 but in his experience, he was so freighted
    0:09:52 with the oppression of bigotry and segregation,
    0:09:54 and so resentful of having to serve
    0:09:58 in the segregated military in World War II
    0:10:03 and be expected to prove what to him was absolutely obvious,
    0:10:06 which was that African Americans could fly
    0:10:08 and fight as well as anybody.
    0:10:10 So he’d left trying to figure out
    0:10:15 how does an African American man in the 1940s,
    0:10:19 who had already gotten a college education,
    0:10:22 went on to get his PhD in economics at Berkeley,
    0:10:27 believe in himself when society is pushing him down.
    0:10:29 And my mom, from her perspective,
    0:10:30 a very different set of challenges,
    0:10:33 but again, the daughter of immigrants
    0:10:34 who came to this country with nothing,
    0:10:36 sent all their kids to college,
    0:10:42 and the expectation for her was also to excel and succeed.
    0:10:45 And what they taught me and my brother was, in essence,
    0:10:50 that we couldn’t let other people define us for us.
    0:10:53 We had to believe in ourselves and know our worth
    0:10:56 and not let others discount us.
    0:11:00 My father had an expression which was,
    0:11:04 if my being black is going to be a problem,
    0:11:08 it’s gonna be a problem for somebody else, not for me.
    0:11:11 In other words, what he understood was that bigotry
    0:11:15 is the function of somebody else’s insecurity.
    0:11:17 And even though there’s structural and institutional
    0:11:21 and legal impediments that he faced every step of the way,
    0:11:24 he did realize that he got to choose
    0:11:26 how he thought of himself.
    0:11:31 And if he let the bigot’s definition of him become his own,
    0:11:33 then the bigot would succeed and he would fail.
    0:11:36 He would not believe in his own capacity.
    0:11:41 And so what he and my mother taught me and my brother, John,
    0:11:46 is that we were worthy, we were capable,
    0:11:48 and we had to believe in ourselves.
    0:11:52 And we would inevitably encounter racism or sexism
    0:11:55 or ageism or whatever it might be.
    0:11:57 But the way to deal with that is,
    0:12:00 in essence, a psychological jujitsu,
    0:12:05 to let that be somebody else’s concern, not yours.
    0:12:09 And to try not to expend your precious mental energy
    0:12:11 doubting yourself.
    0:12:13 And that’s really hard to do,
    0:12:15 whether you’re a male or a female,
    0:12:17 a person of color or not.
    0:12:20 – Yeah, wow, so powerful.
    0:12:22 I’m wondering also, in addition to the lessons
    0:12:24 that you were taking from your parents,
    0:12:24 and you wrote about them,
    0:12:26 I encourage everyone who hasn’t read the book
    0:12:27 to go read for yourself,
    0:12:30 because they’re really a set of extraordinary things
    0:12:33 you took from both your mom and your dad
    0:12:34 and their extended family.
    0:12:36 I mean, you write a lot about some of the memories
    0:12:39 you had growing up, the summers in Maine.
    0:12:41 But I’m also curious in writing your book,
    0:12:43 if there are themes that you kind of discovered
    0:12:47 about yourself that help motivate you
    0:12:50 to become the kind of successful person that you became.
    0:12:54 – Well, writing the book was a real opportunity,
    0:12:58 a gift of a chance to reflect
    0:13:00 and to think back as to all of the things
    0:13:01 that influenced me,
    0:13:04 because frankly, I realized in writing this,
    0:13:06 that essentially from high school,
    0:13:09 until the day I left the Obama administration,
    0:13:12 I’d been going at almost full speed nonstop.
    0:13:17 And what I really realized
    0:13:20 is that the most formative experiences
    0:13:23 were the lessons I learned from my parents,
    0:13:28 and the real challenge I had coming through
    0:13:30 my parents’ divorce.
    0:13:32 You’ve heard how great my parents were,
    0:13:33 and they really were,
    0:13:35 but they absolutely had no business
    0:13:37 being married to each other.
    0:13:39 And there’s– – And you wrote about that a lot,
    0:13:41 and you talked about it. – I write a lot about it.
    0:13:42 I write a lot about it,
    0:13:45 because I realized that I can’t explain myself
    0:13:46 without explaining that experience.
    0:13:47 – Can you impact that a little,
    0:13:49 because I think that’s just really so interesting
    0:13:52 as you found yourself in some of these crisis situations
    0:13:54 later, mostly professionally,
    0:13:57 but also personally, explain that a little bit,
    0:14:00 how you think that your parents’ own relations
    0:14:02 with each other and then their eventual divorce
    0:14:04 kind of contributed to that.
    0:14:07 – Well, by the time I was about seven,
    0:14:12 they were fighting constantly, and sometimes violently,
    0:14:15 and it was really terrifying for me and my brother,
    0:14:18 who was two years younger than me.
    0:14:21 We’d be in bed at night trying to go to sleep,
    0:14:24 and I’d wake up to them screaming and yelling,
    0:14:29 and I was scared, frankly, that it could spin out of control.
    0:14:32 And so I would creep downstairs and spy on them,
    0:14:36 and try to figure out if this was gonna get out of control.
    0:14:40 And if I feared it might, I’d intervene,
    0:14:42 sometimes physically,
    0:14:48 but more often actually trying to talk them down
    0:14:51 and therefore listen to what they were arguing about,
    0:14:53 what were the, who was making what point
    0:14:57 and where reason lay at seven or eight.
    0:14:59 – So you’re doing diplomacy then, really.
    0:15:03 I mean, really a precursor to what came later,
    0:15:04 I guess, professionally.
    0:15:06 I had no idea, obviously, that any of that
    0:15:07 would have any relevance,
    0:15:12 but I did find myself trying to fire fight, in essence.
    0:15:20 And then when I was 10, they actually separated
    0:15:24 and then went through a very bitter and ugly divorce
    0:15:26 and a very public custody battle.
    0:15:29 And so really until I was 15,
    0:15:33 this thing dragged out in one shape or another.
    0:15:37 And I had to make a decision about
    0:15:41 whether I was gonna let it crush me
    0:15:44 or whether I was going to control what I could control
    0:15:48 and not try to be weighted down by what I couldn’t.
    0:15:49 I couldn’t control them
    0:15:51 and how they were dealing with each other,
    0:15:54 but I could control how I performed in school
    0:15:57 and whether I tried to repair my friendships
    0:15:58 which had suffered.
    0:16:01 And whether I was gonna be an athlete
    0:16:03 and a student leader and all this stuff.
    0:16:05 And what I learned from all of that
    0:16:08 is that I could take a hit and keep going.
    0:16:13 And it gave me a degree of confidence in my own resiliency
    0:16:17 that turns out, I think, in retrospect,
    0:16:19 to have been probably the most important,
    0:16:24 formative revelation that I had early on.
    0:16:28 And rather than feeling like, you know,
    0:16:29 this was the worst thing that ever could happen,
    0:16:30 which, of course, it wasn’t,
    0:16:34 but it was bad in my experience.
    0:16:36 I realized, wow, this was really bad,
    0:16:40 but I can still keep doing what I need to do.
    0:16:44 And I think that strength was something
    0:16:47 that I wouldn’t know I’d need down the road,
    0:16:48 but was incredibly valuable.
    0:16:50 – Well, we’ve talked before, you and I,
    0:16:52 about how you have an ability,
    0:16:54 I think you’d agree, to compartmentalize.
    0:16:55 – Yeah.
    0:16:59 – And that it served you well later professionally
    0:17:00 in times of crisis.
    0:17:02 – And by compartmentalize in this context,
    0:17:06 what I mean is, and as I had to do
    0:17:09 as national security advisor, for example,
    0:17:12 when there’s all this stuff going on,
    0:17:17 whether it’s your parents fighting or, you know,
    0:17:21 working on the most difficult problems and crises
    0:17:24 in the world when almost every major decision
    0:17:26 has life and death implications,
    0:17:31 I would found that I was able to do the work of the job
    0:17:34 and be focused and committed to that work
    0:17:39 without it affecting me in every day,
    0:17:43 all day emotionally and being debilitating.
    0:17:47 I feel, you know, if we’re working on a very difficult issue,
    0:17:50 I felt that weight, I felt that pain,
    0:17:55 but it didn’t become something that I could not cope with.
    0:17:59 It didn’t cripple my ability to focus
    0:18:01 and do the job functionally.
    0:18:04 And I think, you know, you have to have some measure
    0:18:06 of that wherever it comes from
    0:18:08 to work on those kinds of issues
    0:18:12 and not, you know, be crushed, for example,
    0:18:15 by the weight of the humanitarian crisis in Syria.
    0:18:17 – Well, and you’ve been in a number
    0:18:19 of those crisis situations, obviously,
    0:18:22 you just mentioned Syria, the humanitarian crisis.
    0:18:24 And I’m just wondering, you’re gonna tie it to this room,
    0:18:28 what best practices or philosophy
    0:18:31 do you bring to bear, Susan, in moments of real crisis?
    0:18:37 – Well, I think my way of approaching crisis is,
    0:18:39 first of all, to get super calm.
    0:18:41 The worst the situation is,
    0:18:46 the more I kinda just chill out and not freak out.
    0:18:51 – I mean, you wrote about the embassy bombings.
    0:18:54 – Yeah, the embassy bombings were an example.
    0:18:58 So, trying to stay calm, trying to gather the information,
    0:19:01 trying to focus on outcomes that we could control
    0:19:08 and not allow the overwhelming nature of the crisis
    0:19:14 to impede our ability to act rationally and effectively.
    0:19:19 So, in 1998, when the embassies were bombed
    0:19:24 in Kenya and Tanzania, my focus was on what can we do
    0:19:28 in the moment to be impactful and effective?
    0:19:31 We had to get search and rescue teams out
    0:19:34 in the shortest order to try to save people
    0:19:36 who were buried in the rubble.
    0:19:40 We had to get the FBI and the other investigative elements
    0:19:42 on the ground to gather the evidence
    0:19:45 so that we could find the perpetrators.
    0:19:48 We had to support the families of the victims
    0:19:50 with information and with comfort.
    0:19:54 We had to do all these things in the moment
    0:19:58 and so my emphasis was on what can we practically do
    0:20:03 immediately without falling apart and despairing
    0:20:06 and how also at the same time,
    0:20:07 and this is what I learned the hard way,
    0:20:11 became better at as I got more experiences,
    0:20:16 recognize that the people you are working with
    0:20:20 process these crises differently than you may
    0:20:23 and may need a different kind of support and approach.
    0:20:27 And so being a compassionate leader that recognizes
    0:20:29 that you need to provide space for people
    0:20:32 to work through their pain and cope with it
    0:20:36 while trying to keep them on the focus to be effective.
    0:20:40 That was where I was lacking at age 32
    0:20:44 and I hope by say 52, I’d gotten a little bit better at.
    0:20:45 – Yeah.
    0:20:47 Well, you know, look, you’ve clearly been
    0:20:51 in some really high pressure situations.
    0:20:54 And at the time you mentioned the embassy bombings,
    0:20:57 you know, you had Jake, your son,
    0:21:00 who was practically a newborn at that point, right?
    0:21:01 – He was a newborn.
    0:21:01 – He was a newborn, right?
    0:21:03 Well, so clearly you’ve been in these
    0:21:07 high pressure situations, but then you add marriage,
    0:21:09 you add kids and somehow you’re managing
    0:21:11 a really complicated life, Susan,
    0:21:13 and you’ve managed a really complicated life
    0:21:16 with a great deal of elegance as an outsider.
    0:21:17 – Thank you.
    0:21:18 – Looking in.
    0:21:20 And I’m wondering just as I think
    0:21:21 about all you’ve accomplished,
    0:21:23 and you have two kids we’ll talk about in a minute,
    0:21:26 and I think Ian is here in the audience, your husband.
    0:21:28 – My wonderful husband.
    0:21:30 – But what are, how are you hacking this?
    0:21:31 How have you done this?
    0:21:33 And what practical tips do you have
    0:21:34 for people in the audience?
    0:21:36 Because I’d sure love to hear them
    0:21:38 and I’m sure others would.
    0:21:41 How do you manage this really robust professional career
    0:21:45 and yet also a robust personal life?
    0:21:48 – Well, I don’t think anybody does it perfectly
    0:21:50 or to their own satisfaction.
    0:21:53 What I learned along the way is that there’s certain things,
    0:21:55 again, that you can control.
    0:21:58 And those are the ones you should focus on.
    0:22:03 So I really tried to take care of myself,
    0:22:06 to sleep as much as I reasonably could,
    0:22:10 to exercise as much as I reasonably could.
    0:22:14 And to prioritize time with family and friends
    0:22:16 because that was rejuvenative time.
    0:22:21 And gave me sort of the strength and the perspective
    0:22:25 to deal with the things I couldn’t control.
    0:22:27 Those were all critically important.
    0:22:30 And then I couldn’t have done it, frankly,
    0:22:34 without an extremely supportive and hands-on partner
    0:22:39 who was very much engaged in his own high pressure career
    0:22:43 as an executive producer at ABC News.
    0:22:47 But was hugely helpful with the kids,
    0:22:50 with my parents who were ailing at the time,
    0:22:51 and in supporting me.
    0:22:56 So I was blessed with all of those systems of support.
    0:23:02 But I think the main things that most of us
    0:23:06 can try to prioritize are taking care of our physical
    0:23:10 and mental health through basic things like sleeping
    0:23:13 and exercising, hopefully eating reasonably well.
    0:23:18 And cherishing that time with the people you love
    0:23:22 as what you need to keep giving you fuel.
    0:23:24 – That’s great practical advice.
    0:23:26 I mean, speaking of kids, you have two.
    0:23:27 – We have two.
    0:23:30 – Daughter Maris, who’s junior in high school.
    0:23:31 – Yes.
    0:23:34 – And then Jake, who’s a senior at Stanford.
    0:23:35 – Yes.
    0:23:36 – And everyone says this about their kids, Susan.
    0:23:40 Oh, there might, anyone who has more than one child
    0:23:42 says, oh, they’re so different from each other.
    0:23:46 But you kind of take things to a new extreme with your kids.
    0:23:47 Because–
    0:23:48 – They took us to an extreme.
    0:23:49 – They took you to an extreme.
    0:23:51 I mean, for those who aren’t familiar,
    0:23:55 I mean, your son Jake, here you are having served
    0:23:59 in the Clinton administration, in the Obama administration.
    0:24:02 And your son Jake is the president of,
    0:24:04 was president of the Stanford College Republicans?
    0:24:05 – Yes.
    0:24:08 – And then you have your daughter,
    0:24:10 and I wish we had a picture of them,
    0:24:11 but anyone can grab the book,
    0:24:14 and there’s pictures of them in the book.
    0:24:18 Maris, you describe us to the left of you and Ian.
    0:24:19 – Yes.
    0:24:20 – And yet the two of them are very close,
    0:24:22 and also close in age.
    0:24:24 And how did that happen?
    0:24:26 And tell us a little bit more about that.
    0:24:29 – Uh.
    0:24:32 (audience laughing)
    0:24:34 – I know you were trying to raise independent thinkers.
    0:24:38 – You know, we wonder sometimes what we fed them,
    0:24:43 and we really did try to teach them
    0:24:46 that they should think for themselves
    0:24:49 and have the courage of their convictions.
    0:24:53 And we tried to impress upon them our respect
    0:24:57 for their independence and individualism.
    0:24:59 And unfortunately, that’s what we got.
    0:25:00 (audience laughing)
    0:25:03 And we love them both.
    0:25:05 I mean, they’re both wonderful,
    0:25:07 bright, thoughtful, committed kids.
    0:25:09 And they’re not just different politically.
    0:25:11 I mean, they’re different temperamentally.
    0:25:13 They could not be more different.
    0:25:16 And sometimes you wonder, like, how’s that possible?
    0:25:19 Same household, same parents, same diet.
    0:25:22 – I mean, you took Jake with you campaigning.
    0:25:26 – Yeah, he used to be, he campaigned for me with me
    0:25:31 in 2008 for Obama in the snows of New Hampshire.
    0:25:35 And this was before he had this metamorphosis.
    0:25:38 – Very hosting speaking engagements at Stanford.
    0:25:39 – Yes.
    0:25:45 And he’s just, you know, he’s gone his own way politically,
    0:25:48 but not emotionally.
    0:25:52 He’s still very much my baby,
    0:25:57 and very much an integral part of our family.
    0:26:01 And so we have some robust debates,
    0:26:04 and sometimes at the dinner table, food will fly.
    0:26:06 (audience laughing)
    0:26:09 Mostly between the kids, I’d like to believe,
    0:26:12 but Ian is here, so I’m not gonna state that categorically.
    0:26:13 – Yeah, that’s great.
    0:26:17 – He knows better, but it’s all good.
    0:26:22 And I’ve learned a lot from having somebody so close to us
    0:26:27 who reflects and represents a very different perspective.
    0:26:30 And one that I think is really important
    0:26:33 for me to understand, but for all of us to understand,
    0:26:36 regardless of whether you’re on the right or the left,
    0:26:38 understanding, we’re in the middle more,
    0:26:40 like some of us wanna be,
    0:26:44 respecting opinions with which we differ,
    0:26:49 and being willing to engage them thoughtfully.
    0:26:51 – Yeah, well, it’s so great to see
    0:26:53 that you were able to raise such independent thinkers,
    0:26:56 in addition to doing everything else
    0:26:58 that you and Ian had going on.
    0:27:01 So hats off for that.
    0:27:03 And then also, you know, I was struck by,
    0:27:05 actually it’s such a coincidence
    0:27:07 that Shonda Rhimes is going to speak next,
    0:27:10 because Shonda Rhimes was one of the people
    0:27:12 who read your book first,
    0:27:15 and she said that reading your book was like a masterclass
    0:27:17 in how to be a powerful woman.
    0:27:19 I think reading your book was like a masterclass
    0:27:21 in how to be a powerful person.
    0:27:24 And many of us think that being a powerful woman
    0:27:26 equals being a career woman.
    0:27:29 But you know, Susan, you told a different story
    0:27:30 in your book.
    0:27:32 You talked not about just being a career woman.
    0:27:35 In fact, I think half of that book
    0:27:39 is about how to be a loving wife, a devoted mother,
    0:27:41 and also caring for your parents,
    0:27:43 both of them, when they were aging.
    0:27:45 And I know they’ve now both since passed.
    0:27:48 At the same time, you’re making these incredibly hard decisions
    0:27:51 and in the public eye, met with a great deal of scrutiny.
    0:27:53 You wrote about a great deal of scrutiny
    0:27:55 when your mom was watching you.
    0:27:59 You said obsessively on CNN during the Benghazi story.
    0:28:00 – Not watching me, but watching the news.
    0:28:01 – Watching the news.
    0:28:02 – Freaking out about me.
    0:28:03 – Right.
    0:28:06 And so amidst all that, you know,
    0:28:08 I wanna know, Susan, like what do you think
    0:28:12 takes to be a powerful woman or a powerful person?
    0:28:13 What are the traits?
    0:28:17 – I would say in the first instance,
    0:28:19 it requires confidence.
    0:28:23 It requires believing in your own self-worth.
    0:28:26 And that’s the huge gift I got from my parents.
    0:28:31 I think it requires integrity and strength
    0:28:33 and compassion, quite frankly.
    0:28:38 I think being powerful means not being hard.
    0:28:44 It means being, to the greatest extent possible,
    0:28:49 somebody who can lead and inspire and motivate others.
    0:28:54 And one of the things I learned as I grew
    0:28:58 from that young Brash assistant secretary
    0:29:03 was that the secret to having effective teams
    0:29:06 is that every member of the team feels valued
    0:29:11 and feels like they care and that they count.
    0:29:13 That you care about them and that they count.
    0:29:18 And so to me, that’s the secret sauce.
    0:29:23 It’s leading in a fashion that values the individuals
    0:29:27 and the human beings on the team.
    0:29:32 And the model, quite frankly, that President Obama set
    0:29:37 and that I and I think others tried to manifest
    0:29:42 was to give all of our colleagues the confidence
    0:29:45 to know that if and when they had to put
    0:29:48 their personal lives first because somebody was sick
    0:29:53 or their kid needed them for something important,
    0:29:56 that the team would fill in behind them
    0:29:59 and that we would manage collectively in their absence.
    0:30:02 Not none of us was indispensable,
    0:30:04 not when I was national security advisor, never.
    0:30:07 I had partners and deputies who could fill in
    0:30:11 and at the lowest levels, that was the way we tried
    0:30:12 to run our teams.
    0:30:15 If you had to go to do what was vitally important
    0:30:19 to you as a human being, then that was what was most important.
    0:30:22 Not least because you weren’t gonna be effective anyway,
    0:30:24 if you were stressing out about this,
    0:30:27 but also because it’s a way of saying we care about you
    0:30:31 and we value you as a human being and we got your back
    0:30:34 and we as a team can fill in behind you.
    0:30:40 And that I think is empowering to one’s team
    0:30:44 and one’s people, but it’s also in many ways
    0:30:47 the source of one’s own strength as a leader.
    0:30:50 – Speaking of being a leader and leadership,
    0:30:53 you have another, I mean, I’m curious what you think about
    0:30:56 then all of the traits you’re mentioning make me think,
    0:30:58 well, I would really like to work for that person.
    0:31:00 I really like them.
    0:31:03 And one of the favorite quotes that I have of yours,
    0:31:04 as you said, and I quote,
    0:31:08 “People who are so intent on being liked
    0:31:10 “may not have the fortitude to do the right thing
    0:31:11 “or the tough thing.”
    0:31:15 And so what advice would you give to leaders?
    0:31:18 A lot of leaders, including some in this room,
    0:31:19 really wanna be liked.
    0:31:22 – Well, I think, look, it’s always better
    0:31:25 to be liked than not be liked.
    0:31:26 Let’s be clear.
    0:31:30 But what I discovered at some stage was,
    0:31:32 at least for me, if I had to choose,
    0:31:34 if I couldn’t have both,
    0:31:38 I’d rather be respected than liked.
    0:31:41 And that was because I realized that sometimes,
    0:31:44 and this is sort of reflected in the quote you read,
    0:31:49 sometimes by being overly concerned about being nice,
    0:31:52 particularly women who sometimes that manifests
    0:31:54 as being deferential or asking for permission
    0:31:58 or affirmation, it’s not effective.
    0:32:01 And it is diminishing of your capacity
    0:32:05 to perform to your optimal level.
    0:32:07 And I realized that just by being me,
    0:32:09 by believing in myself,
    0:32:11 by being an African-American woman
    0:32:13 who really wasn’t asking for permission
    0:32:17 or affirmation in the circles in which I ran,
    0:32:19 some people weren’t gonna like that.
    0:32:21 – You said that you intimidated a lot of people
    0:32:23 most notably.
    0:32:25 – Some men, but I mean, I didn’t set out to do that,
    0:32:29 but I think, and I still don’t set out to do that,
    0:32:30 I’m just trying to be myself,
    0:32:33 but I’m not gonna be somebody I’m not
    0:32:35 to make somebody else more comfortable.
    0:32:36 – Well, I love that you’ve embraced
    0:32:37 those characteristics of yourself.
    0:32:41 – And that leads you to being not always liked.
    0:32:44 And if you’re so obsessed with being liked,
    0:32:48 I think it can lead you to be somebody you’re not.
    0:32:51 And as I said, better to be liked,
    0:32:54 I much prefer that,
    0:32:59 but not at the expense of being who I am.
    0:33:00 – Well, we’re gonna get to a,
    0:33:04 I wanna tell a story which I thought was fake news.
    0:33:06 And then I asked you about it and you said it was true.
    0:33:07 – It’s not fake news, it’s in the book.
    0:33:08 I don’t know where to go.
    0:33:12 – Well, I read it and I thought, oh, this is true.
    0:33:15 There’s a situation where at one time,
    0:33:17 you had to give the middle finger
    0:33:19 to Ambassador Richard Holbrook
    0:33:22 in front of a room full of ambassadors and diplomats.
    0:33:23 Can you tell us about that?
    0:33:27 – So we’re rewinding the tape again to this time.
    0:33:28 – To the brash days.
    0:33:31 – No, but this was not brash.
    0:33:36 This was implementing a philosophy
    0:33:41 that my father had beat into me from a very early age,
    0:33:45 which was don’t take crap off of anybody.
    0:33:47 If somebody is bullying you or dismissing you
    0:33:51 or discounting you, don’t let them get away with it.
    0:33:54 Now, I’d like to think that at 55,
    0:33:56 I might have found the words
    0:33:58 that would have been more appropriate,
    0:34:00 but words failed me in that moment
    0:34:04 and I ended up realizing that my hands had not failed me.
    0:34:11 But the back story is that I’m Assistant Secretary
    0:34:12 of State for African Affairs.
    0:34:15 I’m probably now 33 or 34.
    0:34:18 Ambassador Holbrook had been nominated
    0:34:20 to be the UN Ambassador,
    0:34:22 but not confirmed as confirmation
    0:34:24 had been held up for many months.
    0:34:27 And one day, I’m up on Capitol Hill
    0:34:29 meeting with members of Congress
    0:34:31 and my secretary calls.
    0:34:34 I remember those cell phones that were the size of bricks.
    0:34:37 That was what we were dealing with back in those days.
    0:34:40 And she says, Ambassador Holbrook is in your office
    0:34:43 and he wants to meet with you now.
    0:34:45 And I said, well, I’m sure you explained
    0:34:47 I’m on Capitol Hill meeting with members of Congress.
    0:34:49 I can’t just come back to meet with him now.
    0:34:51 Why don’t you schedule an appointment
    0:34:53 and we’ll figure it out.
    0:34:55 And she said, he’s not leaving.
    0:35:01 And I said, well, okay, then I’ll see him when I get back,
    0:35:02 but that’s gonna be a while
    0:35:04 and make sure you don’t take anything while I’m there.
    0:35:07 (audience laughs)
    0:35:09 So I come back about an hour and a half later
    0:35:12 and sure enough, he’s sitting in my office.
    0:35:15 Very comfortable on my couch.
    0:35:17 And I sit down and I introduced myself
    0:35:18 ’cause we’d never met.
    0:35:22 And I say, what’s so urgent
    0:35:27 that you had to be camped out here in my office?
    0:35:30 And the first words out of his mouth were,
    0:35:35 I dislike you already because you beat my record
    0:35:38 as the youngest regional assistant secretary of state.
    0:35:42 And our relationship went downhill from there.
    0:35:43 (audience laughs)
    0:35:48 And I realized, I was dealing with very talented,
    0:35:53 diplomat on the one hand, but a classic bully on the other.
    0:35:58 So now, maybe a year later, he’s UN ambassador.
    0:36:00 He’s established in the job.
    0:36:03 And he decides in the month that the United States
    0:36:05 is chairing the Security Council
    0:36:07 that he’s gonna make it the month of Africa.
    0:36:09 Africa already consumes a large share
    0:36:11 of the Security Council agenda.
    0:36:15 And that meant that we had to interact quite a bit.
    0:36:18 And he decided he was gonna have a summit meeting
    0:36:22 with the African heads of state from Central Africa.
    0:36:25 And he therefore summoned these heads of state.
    0:36:27 And of course, he was only an ambassador.
    0:36:28 So he had to have the secretary of state
    0:36:31 at least be the person to chair the meeting.
    0:36:35 And he summoned back the ambassadors who reported to me
    0:36:37 who were the ambassadors
    0:36:39 in each of these Central African countries.
    0:36:42 And he calls a meeting on a Sunday afternoon
    0:36:43 in his office in New York.
    0:36:48 And in the meeting are my maybe six or seven
    0:36:50 of the ambassadors who report to me,
    0:36:53 all of whom are 20 to 30 years my senior.
    0:36:58 All men, all white.
    0:37:02 And a handful of my staffers and Holbrook
    0:37:04 and a few of his team.
    0:37:07 And there’s a robust argument that we’re all engaged in
    0:37:10 about a real important policy issue.
    0:37:12 And at one stage after I’d listened to the debate,
    0:37:17 I weighed in with my own opinion, which differed from his.
    0:37:20 And he leans over this table where we’re all seated
    0:37:22 in a very cramped room.
    0:37:24 He’s a big guy with a hulking body.
    0:37:29 And he looks at me and he says, “Ah, I too remember
    0:37:33 when I was a young assistant secretary.”
    0:37:35 (laughing)
    0:37:36 And I was like–
    0:37:37 – And that’s where words failed you.
    0:37:38 – That’s where words failed me.
    0:37:44 And so I did exhibit my dismay with a gesture,
    0:37:49 which was displayed long enough for him to see it.
    0:37:54 And everybody else to see it and like freak out.
    0:37:57 Some with real relish and others with horror.
    0:38:00 And he just kept talking.
    0:38:03 And that meeting continued.
    0:38:05 It became a bit urban legend,
    0:38:08 but the end of the story is I realized
    0:38:11 that I had better discreetly step out of the meeting
    0:38:13 and call back to Washington.
    0:38:15 – To your boss, then, Madeline Albright.
    0:38:17 – To the secretary of state whom I called in,
    0:38:19 I said, “Madame Secretary, I’m calling to report
    0:38:21 that I’ve just given the finger
    0:38:24 to a member of President Clinton’s cabinet.”
    0:38:25 (laughing)
    0:38:28 She said, “Oh, tell me more.”
    0:38:30 (laughing)
    0:38:31 So I explained.
    0:38:33 And at the end she said words to the effect
    0:38:35 of “You go, girl.”
    0:38:38 (laughing and applauding)
    0:38:45 – Well, so fast forward from the brash,
    0:38:48 the brash woman that you once were, Susan.
    0:38:50 And I wanna go right into kind of one of the issues
    0:38:53 that consumed a lot of your time
    0:38:56 when you were working for President Obama was China.
    0:38:58 And now it seems like China’s taking
    0:38:59 even more of a center stage.
    0:39:01 Of course, a lot of people in this audience
    0:39:03 were talking a lot about tech and China
    0:39:07 and government and tech, or maybe not government and tech.
    0:39:10 And I wanna ask if you agree or disagree
    0:39:13 with a statement that I pulled.
    0:39:14 Actually, I won’t tell you who said this.
    0:39:16 I wanna see if you agree or disagree.
    0:39:19 That China poses one of the most severe
    0:39:22 intelligence collection threats to the United States
    0:39:24 and to U.S. businesses today.
    0:39:28 – Yes, agree, very strenuously.
    0:39:29 – And they’re doing it not with traditional
    0:39:34 spy craft anymore, but with putting actually agents
    0:39:37 in private companies and in graduate programs
    0:39:39 and universities in the U.S.
    0:39:43 Like, how should industry leaders in this room
    0:39:45 think about that and grapple with that?
    0:39:48 – Well, China is not only using human assets,
    0:39:53 as you just described, plants or moles.
    0:39:55 But they’re also using cyber tools, as we know,
    0:40:00 to steal intellectual property and exfiltrate data.
    0:40:04 I think that the most important thing
    0:40:07 that I would just share as a former National Security Advisor
    0:40:11 is this threat is deadly serious
    0:40:14 and it’s not getting any better.
    0:40:17 And China’s objective, quite plainly,
    0:40:21 is to compete and ultimately surpass us
    0:40:26 economically, geostrategically, technologically.
    0:40:29 And in fact, they’re explicitly stating it
    0:40:30 as their objective.
    0:40:33 And what they are doing to accomplish that
    0:40:37 is basically using any means at their potential disposal.
    0:40:41 And what we need to do as a nation,
    0:40:44 and I think it applies as much to the government
    0:40:46 as it does to the private sector,
    0:40:47 is to be witting of this threat
    0:40:51 and work really hard to prevent it.
    0:40:56 Recognizing that the most dangerous individuals
    0:41:00 are often the ones inside,
    0:41:02 as we in the United States government
    0:41:06 had learned the hard way many times with Snowden and others.
    0:41:10 That you really do need to take as seriously
    0:41:15 as you possibly can the hardening of your cyber security.
    0:41:21 That you also need to recognize that in your effort
    0:41:26 and work to get a foothold or expand your business in China,
    0:41:29 that as they ask you to do things
    0:41:32 that cause you to share information
    0:41:37 or provide the kinds of access or information that they seek,
    0:41:44 they’re doing it at our expense, geostrategically.
    0:41:47 And I think quite honestly,
    0:41:50 we really need a revolution of patriotism
    0:41:56 in business as well as in the tech sector,
    0:42:01 but as well as across the greater American public
    0:42:05 to recognize that we are unfortunately
    0:42:10 in a kind of Cold War type challenge.
    0:42:16 That’s not to say we have to treat China as an adversary.
    0:42:18 I actually don’t argue that,
    0:42:23 but we have to recognize that we are in a real competition
    0:42:28 that requires us to behave as if we’re in a competition,
    0:42:32 not as if everything is, you know, go along to get along.
    0:42:35 – And you coined that term today, didn’t you?
    0:42:37 The revolution of patriotism.
    0:42:39 And I asked if you’d ever said that before
    0:42:41 and you thought that the revolution of patriotism
    0:42:43 needs to happen in the tech community.
    0:42:45 – It needs to happen, including in the tech community.
    0:42:47 But not exclusively. – And how do we get that started?
    0:42:49 – And by the reason why we were talking
    0:42:54 about the tech community, just so people are understanding,
    0:42:59 given that we are in a era
    0:43:03 of arguably existential competition,
    0:43:09 we need to be matching to the extent we can,
    0:43:12 consistent with our democracy and our values,
    0:43:15 the strength of the Chinese model.
    0:43:16 The Chinese, as you all know,
    0:43:20 are using all elements of their capacity,
    0:43:25 government, the private sector, academia,
    0:43:29 in complete unison to advance their capacities,
    0:43:32 whether in biotech or AI or you name it.
    0:43:35 We’re not.
    0:43:39 We now have lost that historical triumvirate
    0:43:43 between the academy, the private sector and government
    0:43:48 that enabled us to compete against the Soviet Union.
    0:43:52 And there are all kinds of reasons why that’s broken down,
    0:43:57 but it’s the animosity between elements in the tech world
    0:44:04 towards government and arguably vice versa,
    0:44:08 that is in part preventing our capacity
    0:44:11 to concert our efforts consistent with our values
    0:44:14 and free enterprise and all of that stuff,
    0:44:17 that we need to be competitive.
    0:44:20 We’ve need to find ways to put that triumvirate
    0:44:22 in some form or fashion back together,
    0:44:27 not at the expense of our values,
    0:44:31 but in service of our strength and our competitiveness
    0:44:33 and ultimately our way of life.
    0:44:34 – Well, so there are a lot of leaders
    0:44:36 from the tech community in this room,
    0:44:37 and I’m just curious,
    0:44:39 how do you think we can get some of that collaboration
    0:44:42 going again practically?
    0:44:45 – Well, I don’t have all the answers to that,
    0:44:48 but I do think it needs to,
    0:44:53 it could be catalyzed by a sustained exchange
    0:44:57 that was institutionalized
    0:45:00 between the private sector and government.
    0:45:03 And we’ve got really smart, talented people in government.
    0:45:06 We’ve got even more smart, talented people
    0:45:08 in the private sector.
    0:45:10 And I think there’s,
    0:45:13 particularly among some in the employee base
    0:45:14 in the tech sector,
    0:45:17 a real suspicion of or hostility towards government
    0:45:21 and a perception that if you’re working on something
    0:45:24 that serves the US government
    0:45:27 and particularly might advantage us
    0:45:29 technologically or militarily,
    0:45:31 that somehow there’s something wrong with that.
    0:45:34 And that’s what I mean about a revolution in patriotism.
    0:45:36 We need to understand that actually,
    0:45:39 you know, we’re on the same team here.
    0:45:41 And by the way,
    0:45:43 to the extent that many companies
    0:45:46 are making compromises and accommodations
    0:45:49 to open the Chinese market
    0:45:51 and expand their foothold in the Chinese market,
    0:45:54 doing things that quite frankly in my judgment,
    0:45:57 advantage China in this competition,
    0:45:59 but then won’t be comfortable
    0:46:00 cooperating with the US government.
    0:46:03 I think we’ve got things kind of upside down.
    0:46:07 And so a partnership whereby,
    0:46:09 you know, for three, five years,
    0:46:13 you know, best in the brightest in both government
    0:46:16 and industry, you know,
    0:46:19 basically change places, trade places for a little while
    0:46:22 and learn to understand and respect the motives
    0:46:24 and the perspectives and the skills
    0:46:27 and the weaknesses of each,
    0:46:28 would be at least a starting point
    0:46:33 for trying to establish bridges
    0:46:38 and recognize that we are,
    0:46:41 just as we are in many other ways,
    0:46:44 you know, we have more that unites us than divides us.
    0:46:46 – Well, and I suppose you’re bringing,
    0:46:47 you’re on the board of Netflix.
    0:46:50 What kind of voice are you bringing to that boardroom
    0:46:53 and what some of the skills and experiences
    0:46:55 from your own past that you’re bringing to bear?
    0:46:57 Are you having these conversations?
    0:47:00 – Well, I think that the main thing that I bring
    0:47:02 is a deep knowledge and understanding
    0:47:05 about many, many different parts of the world
    0:47:06 and the international landscape
    0:47:09 to a company like Netflix that is increasingly
    0:47:13 growing globally and views its, you know,
    0:47:16 his path forward as being very much
    0:47:18 in the international realm.
    0:47:20 I have an understanding of, you know,
    0:47:23 of crisis management and how government works
    0:47:27 and how to make teams optimize their capacity
    0:47:31 to address crises under pressure,
    0:47:32 all of those sorts of things.
    0:47:35 And also an understanding of the security terrain,
    0:47:38 physical and cyber and otherwise.
    0:47:40 And a recognition that, you know,
    0:47:43 some of the things we’ve just talked about,
    0:47:47 which may not be necessarily front of mind
    0:47:52 far from Washington are actually some of the things
    0:47:55 that companies need to be increasingly mindful of.
    0:47:56 – We’ve covered so much.
    0:47:58 We’ve covered, you know, you’ve written a book,
    0:48:00 you serve on boards, you speak.
    0:48:04 You’re about to be an empty nester a year and a half.
    0:48:07 And I want to just wrap up by asking you, what’s next?
    0:48:08 What lies ahead?
    0:48:09 – We couldn’t just end this.
    0:48:12 – Well, tell me, tell the audience what you told me
    0:48:14 when I asked you this question before once.
    0:48:16 – I’ll, without the profanity?
    0:48:18 – Yeah, please. – Okay, no.
    0:48:21 I don’t know.
    0:48:23 You know, I love my freedom,
    0:48:26 which I now have having left government.
    0:48:28 And I’ve enjoyed very much the process of writing the book.
    0:48:30 And now going on book tour,
    0:48:33 and I love writing my columns with the New York Times.
    0:48:34 And I love serving on Netflix board.
    0:48:37 And I’m interested in continuing
    0:48:41 to participate in board service.
    0:48:45 But the fundamental question that I have to wrestle with
    0:48:48 is do I want to throw myself again,
    0:48:51 full time into any one intensive endeavor,
    0:48:55 whether that’s, you know, in the public sector,
    0:48:57 in the private sector, in the nonprofit world,
    0:49:00 or do I want to continue to have a combination of things,
    0:49:02 which some people call a portfolio,
    0:49:05 that allows me to maximize my freedom.
    0:49:07 And I love maximizing my freedom,
    0:49:10 but I do think I might wake up one day
    0:49:14 and be so grabbed by something that I’m passionate about,
    0:49:16 that I’m willing to jump back in
    0:49:18 and throw myself entirely into it.
    0:49:19 – When you told me today,
    0:49:21 you’re not running for Senate in 2020,
    0:49:24 but you told me that you weren’t ruling out for all time.
    0:49:27 – I’m not running for the Senate from Maine in 2020,
    0:49:30 which is something I’ve thought about for a period of time.
    0:49:37 And that’s mainly because we have this junior in high school
    0:49:41 who deserves to have her parents present
    0:49:45 and not be yanked out of one high school into another.
    0:49:50 But I haven’t given up the thought that I might serve again,
    0:49:52 whether in an elected capacity,
    0:49:53 and I don’t know at what level,
    0:49:56 or in an appointed capacity,
    0:50:00 but I’m also not planning on it and aiming for it.
    0:50:02 I feel very privileged to be able to say
    0:50:05 that I got to serve this country
    0:50:10 under two presidents that I had enormous respect for,
    0:50:14 and that’s the greatest privilege.
    0:50:19 And if that’s the last of my service,
    0:50:20 I’ll feel good about it,
    0:50:25 and I’ll be happy to try to take my talents elsewhere.
    0:50:29 Well, so to speak.
    0:50:31 – Well, Susan, it’s such a privilege to sit down with you,
    0:50:33 and I want to say thank you
    0:50:36 for your service to our country. – No, thank you, no, thank you.
    0:50:37 – On behalf of everyone in the room,
    0:50:39 and also for joining us here today,
    0:50:41 it’s been so great to get to chat with you
    0:50:42 and have this conversation. – Thank you, all.
    0:50:43 – So thank you so much. – Appreciate you.
    0:50:44 – Thank you so much.
    0:50:45 – It’s great to be here too.
    0:50:45 – Thank you.
    0:50:48 (applause)

    Susan shares how she learned to leverage the characteristics of her personality early in her career as assistant secretary of state [2:05]

    One of the important conversations Susan had with a mentor that changed the trajectory of her career [4:50]

    Her parent’s commitment to education, their personal backgrounds, and the legacies they created [8:10]

    The result of instilling self-belief into children and mastering “psychological jiu jitsu” [10:22]

    What the early lessons of family diplomacy taught her [14:00]

    The importance of strategic compartmentalization [16:48]

    How to approach crisis during high stakes situations [18:29]

    How to practice compassionate leadership while maintaining effectiveness [20:10]

    Hacking the concept of “work-life balance” [21:10]

    The required characteristics of powerful leaders [28:14]

    The hard things about leadership and the idea of being liked [31:20]

    The “middle finger story”/the time Susan stood up for herself in an important meeting [33:23]

    Susan talks about China’s intelligence collection in the US [39:45]

    A call for unity between the private, public, and academic sectors [42:54]

  • Building the First CAR T Company

    AI transcript
    0:00:03 Hi, and welcome to the A16Z podcast.
    0:00:04 I’m Hannah.
    0:00:10 This episode is all about the new medical paradigm of CAR T therapy, a new cancer treatment
    0:00:15 that uses engineered T cells to attack cancer and has been so effective in treating childhood
    0:00:19 leukemias, we believe it may actually be a cure.
    0:00:24 In this conversation, Community CEO Oz Azam discusses with General Partner Jorge Conde
    0:00:29 and myself all about what CAR T therapy is and how it all works.
    0:00:35 Starting with the patient and cell journey to how this medicine is developed, manufactured,
    0:00:40 delivered to patients, how different it is to traditional medicines, and then what it
    0:00:45 will take to make these new treatments work on more kinds of cancer, scale to more patients,
    0:00:47 and be more affordable.
    0:00:51 And finally, what company building lessons can be learned from having built the first
    0:00:54 CAR T company of this kind from the ground up.
    0:00:58 This episode was recorded at the annual A16Z summit.
    0:01:03 We’re here to talk about this new kind of therapy, CAR T therapy and what it means to
    0:01:10 be building a company that is delivering this brand new medical paradigm for cancer treatment.
    0:01:13 So let’s just start by giving a little bit of background.
    0:01:16 What is your tagline of here’s what CAR T is?
    0:01:21 So CAR T is also known as chimericantidin receptor therapies, nature’s biggest gift
    0:01:25 that we were given in terms of protecting us from diseases, something called T cells.
    0:01:28 They’re a subset of your blood cells that are called white cells.
    0:01:33 White cells typically prevent infection disease, so they are always surveilling and protecting
    0:01:34 you.
    0:01:42 A B cell produces antibodies, a T cell actually hones in and gobbles up peptides and abnormalities
    0:01:45 that are circulating in the system.
    0:01:50 And the idea was, could you combine the features of a B cell and a T cell together?
    0:01:52 And that’s where the chimera comes in.
    0:01:57 So chimera was an ancient Greek mythological figure, right, that was a hybrid I think of
    0:02:02 a female lion, a dragon and a serpent or something of that nature.
    0:02:07 So the whole idea being, could you combine and create a blend of something with the idea
    0:02:11 that you could create therapies around it.
    0:02:16 And the number of the therapy really involves taking a patient’s T cells and we re-engineer
    0:02:17 those T cells.
    0:02:22 Think of it like a GPS system in cells that we’ve been able to engineer.
    0:02:26 We take cells from a patient, we re-engineer them, we give them back and those cells detect
    0:02:28 cancer and destroy them.
    0:02:32 Best analogy is I can give is like a SIM card into the T cells.
    0:02:37 That SIM card that gets expressed on the surface of those T cells is very unique, it only dials
    0:02:38 one number.
    0:02:43 And that number is a specific cancer antigen or a protein that’s an abnormal protein on
    0:02:45 the surface of cancer cells.
    0:02:50 And we’re able to get these T cells to then actually become killing machines in some ways,
    0:02:56 whereby they identify an abnormal protein on the surface of a cell and they go and attack.
    0:02:59 So let’s do what I call the patient journey and the cell journey.
    0:03:02 So I’m going to take a profile of a child with leukemia.
    0:03:08 You have a child of the age of three or four, they start getting bruising, they go to their
    0:03:13 family practitioner, they do a CBC, they look at their blood count and they have massive
    0:03:17 leukemia in terms of their white cell elevation.
    0:03:22 People gets rapidly assessed, they start chemotherapy and great news, they respond.
    0:03:26 And most kids with leukemia respond really well to chemotherapy.
    0:03:31 Two years later, they’re a routine follow-up and boom, the next thunderbolt comes in.
    0:03:34 Unfortunately, they’re starting to now get leukemic breakthrough.
    0:03:36 There’s more chemotherapies provided.
    0:03:43 But then there comes a point where these patients become what we say in the oncology world,
    0:03:44 refractory relapsing.
    0:03:49 So they’re refractory to any further chemotherapy occasion being given to them and they’re relapsing
    0:03:51 because their disease is worsening.
    0:03:57 And so that patient is then brought in to have their blood drawn to see, do they have
    0:04:01 that right surface marker that you could create this engineer therapy for?
    0:04:06 If they express something called CD19, then we basically harvest out their T cells in
    0:04:11 a process called apheresis, whereby patients blood is withdrawn through a machine and it
    0:04:14 filters out the white blood cells.
    0:04:19 Those cells are then taken and they’re shipped to a central manufacturing facility in the
    0:04:25 case of the University of Pennsylvania, they actually have their own manufacturing capability.
    0:04:26 So they do it on site.
    0:04:27 They do it all on site.
    0:04:28 Okay.
    0:04:29 And remember, this patient is sick.
    0:04:30 Yeah.
    0:04:31 So you’ve harvested their cells.
    0:04:32 Yeah.
    0:04:37 You then go through a process of seven to 10 days where you have to re-engineer those cells.
    0:04:42 Those cells go through a process of cell selection, sort of right cells are extracted.
    0:04:46 They’re then excited by a certain degree with certain technologies that basically make
    0:04:51 the cells in a receptive state that you can then deliver a Trojan horse into it.
    0:04:56 The Trojan horse is this payload that we deliver of the genetic code that expresses this new
    0:05:00 surface marker called a cart on the surface of the cells.
    0:05:04 You then go through a process of three days watching these cells, are they going to grow?
    0:05:08 And you cross your fingers and toes because sometimes they don’t grow.
    0:05:12 These are cells that become fatigued and they just don’t have that oomph, that energy
    0:05:14 that’s needed to grow.
    0:05:17 Then you have to harvest out the cells once they’ve grown.
    0:05:19 Then you have to freeze them.
    0:05:20 Then you have to ship them.
    0:05:24 A mild chemotherapeutic regimen is given to the patient.
    0:05:25 We kind of call it conditioning.
    0:05:30 And conditioning is that you want to get the patients in a certain state that you create
    0:05:35 space in their body for them to receive these cells and the cells to expand.
    0:05:38 So the cells are given as one infusion.
    0:05:42 And what you typically see is a spike in the patient’s fever.
    0:05:46 These cells start to multiply very, very rapidly.
    0:05:50 And at the same time, they’re pushing out massive amounts of protein and they start
    0:05:53 to literally attack the cancer wherever they see it.
    0:05:56 Cancer when it’s destroyed releases a lot of toxins.
    0:05:59 And that manifests itself in something called cytokine release syndrome.
    0:06:00 It’s like a storm.
    0:06:01 It’s like a storm.
    0:06:03 That’s what they call the cytokine storm.
    0:06:07 And so having that patient available to be able to, for example, move to an ICU unit
    0:06:12 if needed, it requires a lot of coordination and sophistication, right?
    0:06:16 So you then go through that process and hopefully by three, four days you’re seeing that window
    0:06:17 of, is this patient really responding?
    0:06:21 If you don’t see the cytokine storm, it means the product’s not working.
    0:06:25 We actually look forward to an adverse event, which is really weird in medicine.
    0:06:28 Because if you don’t see it, you know the product’s not working.
    0:06:33 28 days later when the patient is better, the fever’s subsided and you do a bone marrow
    0:06:38 biopsy, you do various blood tests and you see over 90% of kids initially in the trials
    0:06:41 got complete remission after 28 days.
    0:06:46 And there are children out now, out, you know, seven, eight, nine years now.
    0:06:47 And that is the cure.
    0:06:49 That’s persistent and durable cure.
    0:06:53 We hope that they remain in this state where these cells are constantly in surveillance
    0:06:54 in the body.
    0:07:00 So should a signal arise of an abnormal protein, these cells can then attack it.
    0:07:03 So I’ve given you a sense of the cell journey and the patient journey.
    0:07:05 Now you think about that, creating a product around that.
    0:07:07 It’s a whole new area of medicine, right?
    0:07:12 The infrastructure, how do you begin to scale a process like that?
    0:07:15 To build the pipes and the infrastructure to scale?
    0:07:21 If I go back to 2013, literally, we’d be in the size of a room like this podcast room.
    0:07:25 And literally we would have tubes and bags hung on the wall.
    0:07:30 It was literally our sort of brainstorming war room of how do we take this process from
    0:07:36 an academic, open process, close the manufacturing, meaning lock it to good manufacturing practice
    0:07:42 standards, process development, analytical development, vector scientists, and technical
    0:07:44 operations personnel are working around the clock.
    0:07:47 So again, very different way of practicing medicine, right?
    0:07:52 This was like the Wild West in some ways in the early days, but we did it and we learned
    0:07:54 a lot through that process.
    0:07:58 We acquired our own manufacturing facility because we’re not in the business of just
    0:07:59 creating product for chronic sake.
    0:08:01 We want to actually expand it globally.
    0:08:06 We need to bring down the cost of goods radically for these therapies because they are really
    0:08:07 expensive to make.
    0:08:12 So unless you invested upstream in there, then how are you going to be able to scale and
    0:08:14 actually make these products affordable?
    0:08:17 Isn’t the same time, you know, generate revenue for the company?
    0:08:19 The process is so important.
    0:08:21 It’s so different to traditional medicine.
    0:08:25 So you have to be able to manufacture this therapy.
    0:08:30 You’ve got to be able to manage the logistics that go from patient to the provider, from
    0:08:34 the provider to the manufacturer, back to the provider, back to the patient, what you
    0:08:36 call the vein-to-vein logistics.
    0:08:45 So is there really any other way to do this but to be a full stack or fully vertically
    0:08:50 integrated company if you’re going to commercialize these types of therapies?
    0:08:54 I think the more and more you see where the world is moving to and you look at the personalized
    0:08:58 nature of what we’re doing, whether these are current generation products or off the
    0:09:04 shelf products in the future, that ecosystem being understood from the patient journey,
    0:09:08 the cell journey, cell logistics to your point, adverse event management, and as you think
    0:09:13 about the interface of tech for the future, which is going to be required here, whether
    0:09:18 that being diagnostics, whether that being management of patient, patient selection,
    0:09:24 or whether you’re looking at blockchain, for example, in terms of secure chain of identity.
    0:09:28 Because look, if I’m taking your cells, you want to guarantee I’m giving your cells back,
    0:09:29 right?
    0:09:30 Right.
    0:09:33 So there’s a whole security apparatus in this and that people just don’t consider when
    0:09:34 they first get into it.
    0:09:39 If we didn’t have that pillar of manufacturing, if we didn’t have the research engine, if
    0:09:43 we didn’t have the ability to learn from each patient that we manufactured, what’s working
    0:09:47 well, do we need to add a bit of this reagent, do we need to stimulate the cells in a certain
    0:09:53 way, all of that repeat learning, that can only happen in a full stack company.
    0:09:57 In order to be able to really maximize and create great products, we decided to own that
    0:09:58 process ourselves.
    0:10:03 So can you imagine that if we see success in a clinic and we don’t have the manufacturer
    0:10:09 to go in hand, I kind of feel that’s unethical in terms of the breakthrough speed with which
    0:10:14 science is evolving, but not being able to manufacture the product would be such a shame.
    0:10:19 Building this new kind of technology, this new kind of medicine, the talent, the culture,
    0:10:21 and the platform.
    0:10:22 Everything new, essentially.
    0:10:24 That sounds really painful.
    0:10:25 It was not easy.
    0:10:30 It was actually developing products in a different way against the paradigm.
    0:10:35 So in our world of drug development and product development, there’s a very well-established
    0:10:37 cycle of how you do things.
    0:10:41 It’s memorialized with the FDA, there’s guidance, etc.
    0:10:45 But try developing something that regulators have never done before, or companies have never
    0:10:46 done before.
    0:10:50 In my career, I never thought I’d work on something that could be curative.
    0:10:55 I worked on things that could help people, they could improve their health.
    0:10:59 I worked on many things that didn’t do anything for patients, products failed.
    0:11:04 But once you’ve touched success in terms of curing a patient, and I use that word very
    0:11:09 carefully because as a physician, you always think twice about you’re really curing somebody.
    0:11:12 When you’ve done that with a product, it changes your whole perspective about medicine and where
    0:11:14 the world could be.
    0:11:18 If you have the right team behind you, if you have the right culture behind you, and
    0:11:20 if you have the right platforms and technologies.
    0:11:23 So you had 400 people within the Cell Engine Therapy Unit in Novartis.
    0:11:26 You’re now the CEO of C-Munity, your own startup.
    0:11:32 So C-Munity is a T-cell engineering company that’s focused on curing cancer.
    0:11:38 We’re doing this by developing therapies in the form of either CARTs or TCRs, T-cell receptor
    0:11:43 technologies, and mainly going down the road less trodden when it comes to the tougher
    0:11:48 kinds of cancers that are mainly in the solitumous space as opposed to hematological cancers,
    0:11:51 which there have been great successes in, still an unmet need.
    0:11:56 But there’s an even huge, huge, bigger unmet need with patients with solid cancers, which
    0:11:57 is where we really want to focus.
    0:12:01 So taking what you did for blood cancers, essentially, and moving that to solitumous.
    0:12:05 Correct, and pivoting from that, and the lessons that we’ll learn, and very, very important
    0:12:11 lessons, taking that into how do we develop these therapies for patients who have no other
    0:12:12 choices left.
    0:12:15 Can I ask you a question around the technology and how you’re going to build out your product
    0:12:16 pipeline?
    0:12:17 Sure.
    0:12:23 I’m going to hinge on how you can essentially engineer cells for increased and expanded
    0:12:24 functionality.
    0:12:25 Sure.
    0:12:32 So one simplistic way to think about this is, in CAR-T, it’s an oversimplification to compare
    0:12:33 it to software.
    0:12:34 But I will.
    0:12:39 Every generation of CAR-T is built on the previous generation in some ways, and you
    0:12:41 can swap in modular components.
    0:12:43 Cassettes, modules, whatever.
    0:12:44 Yeah.
    0:12:50 It’s the functionality so you can go across different and more complex cancers.
    0:12:55 So going from liquid tumors, like the lymphomas, like the leukemias, into solid tumors.
    0:13:00 I want to talk a bit about how you think about what needs to happen for you to bring the
    0:13:01 cost down.
    0:13:03 What has to happen from an engineering standpoint for that to happen?
    0:13:04 Yeah.
    0:13:06 So let’s break it down.
    0:13:11 So how do T cells actually bind or stick to a target?
    0:13:13 Think of Velcro, right?
    0:13:16 So when Velcro attaches, the idea was that what you actually want is that Velcro never
    0:13:17 to come off.
    0:13:19 It sticks permanently, really well.
    0:13:25 And that was known as high affinity, especially in terms of antibodies.
    0:13:29 And people realize, actually, that’s not such a good idea because you actually get off target
    0:13:30 effects.
    0:13:31 You actually get something sticking where it shouldn’t.
    0:13:32 There’s a problem.
    0:13:37 So then this maturing of something called affinity tuning happened where it’s the Goldilocks
    0:13:38 thing, right?
    0:13:43 It’s too hard not to stuff just the right amount where you get a T cell touching and
    0:13:47 activating, but not totally binding.
    0:13:51 I think that’s been a bit of revolution in terms of T cell engineering thinking.
    0:13:53 Then it’s actually developing multiple warheads.
    0:14:00 So actually targeting more than one protein, abnormal protein, or antigen, that multivalency
    0:14:01 as we call it.
    0:14:04 And in certain cancers like glioblastoma, we know we probably have to attack three,
    0:14:09 four different kind of surface marker proteins for patients to get a benefit.
    0:14:13 Then there is the engineering component of getting these cells to power on.
    0:14:17 So if you think of the engine of the cell, how do you really give it more choke so these
    0:14:20 cells really power up and co-stimulate?
    0:14:25 How do we armor these cells better to help them overcome immunosuppression?
    0:14:30 Because Mother Nature’s, one of the things that she’s done an amazing job of is actually
    0:14:32 giving cancer privilege, right?
    0:14:36 And there are various ways in the system that cancer cells trick the human body.
    0:14:38 One of them is immunosuppression.
    0:14:42 So we now have the capability through gene editing, for example, to overcome that or
    0:14:46 through arm ring of cells, which was not possible before.
    0:14:50 There’s actually ways where you can target the outer casing, if I can call it of cancer,
    0:14:54 and kind of make a dent in that armor to allow payloads to go in.
    0:14:59 So payload delivery is another key factor, right, that’s changing the way we think about
    0:15:01 liquid to solids.
    0:15:07 So all these modules now, the lessons learned from hematological emergencies, now pivoting
    0:15:11 towards solid tumors, these principles are going to be really important, not just for
    0:15:14 companies like us, but for the entire field.
    0:15:20 How do we get these therapies into patients earlier in their cancer journey, if and when
    0:15:24 it’s appropriate for them to be treated with these kinds of therapies?
    0:15:27 And what needs to happen from a product standpoint to enable that?
    0:15:31 This whole sort of scale business, that’s really going to come where gene editing comes
    0:15:37 into play, in theory, if you have not the patient cells, but cells from multiple sources.
    0:15:43 So you’re a donor, I’m a donor, we have great cells, those universal cells be made into sort
    0:15:47 of batches from which you can then create an off the shelf product.
    0:15:50 That’s going to help reduce the cost of goods, and that’s where the future will move to.
    0:15:54 And there are companies that are actually in that space now, we’re in the research stage
    0:15:55 of that now.
    0:15:59 But again, that’s going to be another flexion point for the field in terms of bringing out
    0:16:00 costs.
    0:16:07 Novartis, Kim Raya, the first CAR-T product, was going after leukemias, lymphomas, just
    0:16:09 about 10% of all cancers.
    0:16:13 You’re going after the other 90% plus.
    0:16:21 So you’re going after a call at 10 times the market with a 10th of the team today.
    0:16:25 Is there something fundamentally different about how you build a startup company from
    0:16:32 scratch versus a startup company within a large company that you had at Novartis?
    0:16:35 There’s huge differences.
    0:16:37 Let’s talk about the talent.
    0:16:42 So I quickly bought on board a very good colleague of mine from Novartis, Michael Cresciano,
    0:16:47 and he is the resident dealmaker when it comes to everything sound gene therapies.
    0:16:51 So between the two of us, we’d actually had a cultural sense of what we had built previously
    0:16:55 and the essence of what we needed to keep, but what we needed to pivot to.
    0:17:03 And then clearly the speed with which you have to recruit is a very different pace,
    0:17:04 right?
    0:17:09 I mean, within the Novartis world, it was fast because we went from two people to within
    0:17:11 six months having 400 people.
    0:17:16 But literally, we lifted and shifted groups out of different functions in.
    0:17:18 Sometimes they had a choice, sometimes they didn’t.
    0:17:24 But in the startup world, you really are relying on your network very heavily, but also really
    0:17:30 digging in quickly about people who fit really well in big pharma may not necessarily work
    0:17:34 out in startup situations and small biotech.
    0:17:36 So really understanding what is the motive of that individual.
    0:17:41 I mean, we get out of bed thinking about T-cells, we go to bed at night thinking about T-cells.
    0:17:42 Yeah.
    0:17:46 Well, to your point also in the startup, everyone is choosing to be there and they must be making
    0:17:48 the choice from a kind of passion.
    0:17:53 You know, many colleagues who came on board had experienced malignancy themselves, or
    0:17:58 they’d lost a loved one or loved ones in many cases that becomes very, very personal.
    0:18:01 In a small company, you have to phase and stage your hiring.
    0:18:04 You can’t just do a scattergun approach, right?
    0:18:08 Getting a high performing team set up quickly where you buffer each other’s weaknesses
    0:18:10 but play to each other’s strengths.
    0:18:15 That’s a really, really important trait in startups because there’s no room for insecurity.
    0:18:20 You have to have huge self-awareness about what you know and what you don’t know and
    0:18:21 times on your side.
    0:18:28 It weighed heavily on me the letters and Facebook postings I got from patients and their families
    0:18:29 in my former life.
    0:18:32 The patients we needed to treat have tried absolutely everything.
    0:18:34 The sense of urgency was there as well.
    0:18:39 For the first 12 months, it was all we needed at that time to really secure the operations
    0:18:40 of the company.
    0:18:43 There were many times actually the company should have died.
    0:18:48 For example, there was IP that maybe wasn’t what we thought it was before.
    0:18:52 There were platforms that maybe the experiments weren’t reading out the way they thought they
    0:18:53 would.
    0:18:54 It all worked out.
    0:18:59 But during that phase, I never knew I could be so tenacious because I tasted such huge
    0:19:03 success in my former life to now do this again and think, “Oh my God, could we really
    0:19:04 fail?”
    0:19:06 And we really could have.
    0:19:08 But it’s patients are waiting, right?
    0:19:10 There’s nothing like famine to make you hungry.
    0:19:11 Oh, absolutely.
    0:19:12 Absolutely.
    0:19:18 And the next phase of the people side really came in when we had to instill discipline
    0:19:23 process, building our quality systems, starting to write protocols, starting to really gear
    0:19:27 up for regulatory guidances, submitting INDs.
    0:19:29 And sometimes you get people on the bus.
    0:19:32 Then you get to figure out, are they on the right seat on the bus?
    0:19:34 Because you hire utility players, right?
    0:19:37 But you also need specialist players as well.
    0:19:39 So how do you move them around the seats on the bus?
    0:19:41 Like, should they have got on the bus?
    0:19:42 Absolutely yes.
    0:19:46 Then sometimes you realize, well, you know, this person may be better in this seat versus
    0:19:47 that seat.
    0:19:49 So we went through that phase as well.
    0:19:52 And did you find that kind of internal cultural building?
    0:19:58 I mean, because this is a new kind of bio company, really, where there are kind of internal
    0:20:01 cultural issues as well, where you’re getting different types of people with different
    0:20:02 approaches to things.
    0:20:03 Sure, absolutely.
    0:20:06 People bringing in different baggages, right, from a cultural perspective.
    0:20:11 The teaming in our world is so different because you have to integrate what is traditionally
    0:20:14 clinical thinking with manufacturing science thinking.
    0:20:17 In our world, the process is the product, right?
    0:20:18 That’s a very different proposition.
    0:20:20 So let’s fast forward to the end of the journey then.
    0:20:25 So let’s assume that you’re able to demonstrate that these therapies are effective, you’re
    0:20:31 able to manufacture them, you’re able to manage the logistical complexities.
    0:20:36 If we look at the first generation of CAR T therapies, is it fair to say that commercially
    0:20:40 they haven’t lived up to the expectation of what they might look like?
    0:20:44 I mean, first of all, introducing a new order in how medicine’s practice is not easy.
    0:20:48 I mean, you’ve got to think about how a physician is going to get paid, how does a health care
    0:20:53 system make money out of this, what’s the cost of infrastructure build, are they going
    0:20:59 to actually invest in a stem cell lab, are they going to invest in the logistical wiring,
    0:21:02 and at the same time, do clinical trials and also be a commercial center.
    0:21:07 So I think people underestimated the complexity of what it would take.
    0:21:13 But at the same time, nobody’s disputing the stellar clinical results that you get.
    0:21:15 I think the curves will pick up.
    0:21:20 It just took longer for the uptake for a specialty product to be introduced.
    0:21:24 And hindsight, maybe there were certain things we could have done a lot earlier.
    0:21:28 There’s a finite amount of resource investment you could make at certain pivot points within
    0:21:30 the lifecycle of a product.
    0:21:34 But I’m pretty optimistic that the players that are going to be in this space are going
    0:21:39 to double down and increase the actual spend that’s needed to really make these products
    0:21:43 successful because at the end of the day, none of us are in this business to break the
    0:21:45 health care budgets of any country.
    0:21:49 We also know we have a challenge because the products are expensive to develop.
    0:21:53 I think over time, we’ve already seen this, the cost of goods have come down.
    0:21:58 We’re one or two engineering steps away from some radical optimization of these products.
    0:22:01 We are going to need access to large amounts of data.
    0:22:08 We are going to need the AI and adjacent thinking to be blended into the cell journey and the
    0:22:10 patient journey and the commercial journey.
    0:22:14 The revolution started, it ain’t over yet, and there’s a couple more wins that I think
    0:22:17 we’re going to see in the next couple of years in the T-cell engineering space.
    0:22:23 Jorge, you also built a company where it required you to kind of like both create a new ecosystem
    0:22:25 and enter the existing ecosystem.
    0:22:29 What do you think is your primary tool when you were doing that in this particular space?
    0:22:30 How did you navigate that?
    0:22:35 When you think about new modalities, new therapies, you know, biotech-based products, the big
    0:22:37 challenge is exactly as you say.
    0:22:41 I mean, it’s just the acceptance of, first of all, clinical acceptance, which should
    0:22:48 have a high bar in terms of what people think of as a new modality that’s worth pursuing.
    0:22:50 That should be a high bar and it is.
    0:22:54 But the reimbursement bar is also incredibly high for any new modality because the costs
    0:22:56 are obviously additive at some point.
    0:22:59 That tipping point, it does take longer than you think it’s going to take.
    0:23:00 For sure.
    0:23:05 But when it arrives, then the dominoes do start to fall quickly.
    0:23:09 And so the one question to you as it relates to the cell therapies is one of the things
    0:23:15 that most new therapies don’t have is the potential to demonstrate something that starts to look
    0:23:17 like a cure.
    0:23:23 And so because you had sort of these incredibly outsized effects for the first generation
    0:23:29 of CAR-T, I would have thought that reimbursement would have followed pretty quickly because
    0:23:32 you’re actually seeing children get cured.
    0:23:33 It’s a really good point.
    0:23:36 So I think for the leukemias for children, it was a no-brainer.
    0:23:42 It happened, if you think about it, relatively quickly in the US because it was so compelling.
    0:23:44 So what’s your standard of care?
    0:23:47 Your standard of care is a stem cell transplant for a kid with leukemia.
    0:23:53 So cost of a stem cell transplant, believe it or not, is $750,000 to $1.3 million, depending
    0:23:55 on your ZIP code.
    0:23:58 When you’ve fully loaded costs, you add it all in, right?
    0:24:06 So you are pricing a product at $450,000, $425,000 in case of Kim Ryan, and after rebates
    0:24:09 and discounts, whatever that is, right, you can figure out what that number is going to
    0:24:10 be roughly.
    0:24:14 You’re still getting pretty good value when you think about it.
    0:24:20 I think the biggest thing for the payers was, and still remains, for cell therapies or gene
    0:24:26 therapies, anything where there’s a price tag that is higher because of the cost of manufacturing,
    0:24:33 for example, is that don’t burden us with a one-time upfront cost for your therapy.
    0:24:38 We understand that you’ve spent a lot of money in R&D, but this whole notion that we’re
    0:24:43 going to be able to discharge our cost up front as a big ticket, I think that’s a thing
    0:24:44 of the past.
    0:24:45 And there’s precedent now for that.
    0:24:50 And you’ve seen presence now with innovation coming through in terms of reimbursement, pay
    0:24:54 for performance kind of models, you’re going to see, I think, variations in that and versions
    0:24:55 of that.
    0:24:59 At the same time, the cost of goods of these products is coming down, be it gene therapy
    0:25:00 or cell therapy.
    0:25:04 It’s a math problem, right, engineering problem, and in the next five years, that will improve.
    0:25:09 But payers, if you look at a medical director in Etna, United, whatever, they have a finite
    0:25:10 pop.
    0:25:14 They want to know, in four, five years’ time, what am I going to be dealing with, right?
    0:25:19 They’re getting so much better now at engaging with companies like us to forecast and think
    0:25:23 from an actuarial perspective, right, how am I going to manage a business in this area?
    0:25:28 So part of it is, I want some companies like us to be progressive and be creative and have
    0:25:32 the engagements earlier, you know, because it is a brave new world.
    0:25:34 Nobody has the magic answer here.
    0:25:39 So the earlier you get into dialogue with payers and advisors in that setting, the better off
    0:25:43 we’re going to be for the sake of patience and for the company as well, long term.
    0:25:46 So the first generation of car came out of Novartis.
    0:25:54 The second generation of car, T, is coming out of companies like Team Unity.
    0:25:58 There was a reason why the second generation didn’t come out of Novartis.
    0:26:05 In other words, that you started a new company to go after sort of the next horizon.
    0:26:10 How do you make sure that the third generation of car comes out of Team Unity and not out
    0:26:13 of a new co that hasn’t been imagined yet?
    0:26:14 Curiosity, right?
    0:26:15 You have to have that.
    0:26:17 Your bedrock is a company.
    0:26:18 Where is the world moving to?
    0:26:21 Where is the next best idea coming from?
    0:26:26 It’s how you think about staying ahead of the curve and building that network and, you
    0:26:31 know, opportunities arise in amazing scientific settings where you least expect them.
    0:26:34 I think also people in our world, who are known as cell whisperers, who really have
    0:26:39 seen there, been there, done it all and have seen what works, what doesn’t, institutional
    0:26:41 memories are a really important thing.
    0:26:44 I’ve got founders like Jim Riley, Carl June.
    0:26:47 You know, they first started off this field in HIV.
    0:26:51 They were actually trying to find a cure for HIV with, you know, T cells.
    0:26:57 They stumbled upon decoding the HIV virus and realized that this can be a great payload
    0:26:58 and look now.
    0:27:03 They’re actually curing cancer with a denatured approach to HIV.
    0:27:07 So the craziest ideas come from the craziest parts of science in the world, right?
    0:27:11 Who would have thought, you know, at the time that that would be a path that 30 years later
    0:27:14 would be potentially a cure for cancer?
    0:27:17 So last question, takeaway for our other entrepreneurs and founders.
    0:27:23 You’ve now twice built a product and a company that’s really pushing all kinds of new limits
    0:27:27 and regulatory and policy and manufacturing and delivery and all kinds of things.
    0:27:31 What’s something that you would do differently now if you were going back and doing it all
    0:27:32 over again?
    0:27:35 I think if I had my time again, there are certain things I would have accelerated in
    0:27:37 terms of my advisors.
    0:27:42 Don’t wait for an issue to arise before you think, hey, you know what, I got this problem.
    0:27:45 I should try and find somebody that has an external lens to this.
    0:27:48 And it’s where the humility piece has to come in.
    0:27:50 You cannot know everything.
    0:27:52 Even your team cannot know everything.
    0:27:56 So then how do you appoint the right directors to your board who bring different skill sets
    0:27:57 and advisors?
    0:28:01 I’d accelerate all of that thinking three times faster than I’d done it the first two
    0:28:02 times.
    0:28:09 So agility, tenacity, again, not giving up, the network that you have to create as an
    0:28:14 entrepreneur in this space to really think, good ideas can come from anywhere.
    0:28:17 And just staying curious constantly, I mean, the one nice thing about our field is we’re
    0:28:22 competitive, but we’re also very, very collaborative as well in this space, more so than you will
    0:28:26 see in other biotech spaces, because there’s a humility as well that we just cannot solve
    0:28:27 everything ourselves.
    0:28:32 We will need to beg, borrow, partner with others if we want to be successful, the sake
    0:28:33 of patience.
    0:28:34 You can’t do it all yourselves.
    0:28:37 So humility, curiosity, and the right team.
    0:28:38 That’s good advice.
    0:28:39 Absolutely.
    0:28:40 Thank you so much for joining us on the A16Z podcast.
    0:28:41 Thank you.
    0:28:42 [end of transcript]
    0:28:43 [end of transcript]
    0:28:43 [end of transcript]
    0:28:44 [end of transcript]
    0:28:44 [end of transcript]
    0:28:45 [end of transcript]
    0:28:45 [end of transcript]
    0:28:46 [end of transcript]
    0:28:56 [BLANK_AUDIO]

    with @OzAzamTmunity1, @JorgeCondeBio, and @omnivorousread

    CAR T therapy, the groundbreaking new medicines that uses engineered T-cells to attack cancer, has been so effective in childhood leukemias that we believe it may actually be a potential cure. But this isn’t just one new medicine, it’s an entirely new therapeutic tool—and a total paradigm shift from most traditional medicines we’ve seen before.

    Tmunity CEO Usman “Oz” Azam was previously the head of Cell and Gene Therapies at Novartis, in many ways the first CAR T company and the team brought us blood cancer CAR T-cell therapy Kymriah—the first cell-based gene therapy to be approved in the US. In this conversation, Azam discusses with a16z’s general partner Jorge Conde and Hanne Tidnam what CAR T therapy really is and how it all works. The conversation begins with the “patient and cell journey” of this treatment and how this medicine is developed, manufactured, delivered to patients; why exactly it’s so different traditional medicines; what it will take to make these new medicines work on more kinds of cancer, scale to more patients, and cost less; and finally, what company building lessons can be learned from building the first CAR T company of its kind from the ground up.

    This episode was recorded at the annual a16z Summit.

  • Rebel Talent

    AI transcript
    0:00:04 – Hi, and welcome to the A16Z podcast, I’m Hannah.
    0:00:06 This episode is all about rebel behavior
    0:00:09 with author and Harvard business professor Francesca Gino,
    0:00:12 who wrote the definitive book on rebel talent
    0:00:15 based on studies of why leaders and employees
    0:00:17 make the decisions they do at work.
    0:00:20 Not all rebels are troublemakers and rabble-rousers.
    0:00:22 Rebels often change the world and the workplace
    0:00:24 for the better, pushing organizations
    0:00:28 towards creativity and innovation and out-of-stagnation
    0:00:30 with their unconventional outlooks.
    0:00:32 We start with what rebels and rebellious behavior
    0:00:36 in this context really means to the values and characteristics
    0:00:37 these types of leaders tend to have
    0:00:40 and stories of how rebels can create constructive
    0:00:42 and positive change.
    0:00:44 So in your previous work, you had focused on rule-breaking,
    0:00:46 but in the negative sense, what caused you to shift
    0:00:49 towards the positive aspect of rebellious behavior?
    0:00:51 – What I wanted to do is shift our thinking
    0:00:53 when it comes to rebels.
    0:00:55 I had spent so many hours in organizations
    0:00:59 where the rebels are thought of as the troublemakers,
    0:01:02 the outcasts, people who break the rules
    0:01:05 just for the sake of breaking rules
    0:01:06 without too much thought.
    0:01:08 Sometimes they’re even called the jerks
    0:01:10 or the people who slow you down
    0:01:12 in decision-making processes.
    0:01:15 I really wanted to shift that thinking and say,
    0:01:18 rebels are in fact not people who break rules
    0:01:19 just for the sake of breaking rules,
    0:01:21 but they’re people who break rules
    0:01:24 that hold them and others back in a way
    0:01:26 that is positive and constructive for the organization.
    0:01:30 – In your definition, rebel is positive.
    0:01:32 Someone who understands those rules
    0:01:36 and chooses to push past them in creative ways.
    0:01:37 – That’s exactly right.
    0:01:39 So I’ve been spending quite a bit of time
    0:01:41 in all sorts of organizations
    0:01:43 and I was researching different leaders,
    0:01:46 spending time with them, looking at what was unique
    0:01:49 about their rule-breaking that was creating positive change
    0:01:52 for their organizations or society more broadly.
    0:01:55 I’ll give you a concrete example of this story
    0:01:58 that really brought it together for me.
    0:02:02 I was taking a stroll in a bookstore in Cambridge
    0:02:05 where I live and I saw a book
    0:02:06 and the title caught my attention.
    0:02:11 The title was Never Trust a Skin Italian Chef.
    0:02:12 And I’m Italian, I was born in Italy
    0:02:15 and so I started flipping through the pages
    0:02:17 and there were these beautiful pictures of dishes
    0:02:21 that I grew up with, but they actually look nothing
    0:02:23 like the dishes I grew up with.
    0:02:25 And this was the story of a chef.
    0:02:29 His name is Massimo Boutouro created a restaurant
    0:02:33 where he decided to reinvent traditional Italian dishes.
    0:02:34 If you know anything about Italians,
    0:02:35 two things are true.
    0:02:39 First, we have a lot of rules when it comes to cooking
    0:02:41 from the type of sauce that goes with the specific type
    0:02:45 of pasta to how is it that you make these dishes.
    0:02:49 And also we cherish our old ways.
    0:02:51 We’re talking about recipes
    0:02:53 that have been passed on for centuries.
    0:02:56 He studies the tradition really well,
    0:02:57 but then he broke away from them
    0:03:00 and he came up with something that was very innovative.
    0:03:03 And so it really triggered this question of
    0:03:05 how is it that he did that?
    0:03:07 Why is it that he was able to be successful?
    0:03:10 – So is it because the output was better?
    0:03:13 What was it that made his rule-breaking positive?
    0:03:16 – He was raising questions about rules,
    0:03:18 processes, tradition that exist
    0:03:21 and that most of us take for granted,
    0:03:24 but he was showing curiosity in a way that allowed him
    0:03:26 to bring out his creativity in a context
    0:03:30 that had not seen a lot of creativity for a long time.
    0:03:33 So you’re breaking rules in a context
    0:03:36 where people have not shown curiosity.
    0:03:39 They’ve taken things for granted,
    0:03:41 but in the breaking of the rules,
    0:03:46 you end up with innovative solutions to problems that,
    0:03:47 again, you’ve taken for granted
    0:03:49 of not questioned in the past.
    0:03:51 – So it’s a way out of stagnation, essentially.
    0:03:56 – Exactly, and it’s also a way out of routines
    0:04:00 or processes that we just accept for the way they are
    0:04:02 rather than approach with curiosity.
    0:04:04 – What is the line?
    0:04:06 I mean, should we all be exhibiting
    0:04:10 that kind of rebellious sort of tendencies all the time
    0:04:11 or are there certain conditions
    0:04:14 under which it’s appropriate and when it’s not
    0:04:16 and when is that rebel behavior really
    0:04:18 the most productive and when is it just
    0:04:20 leading you into chaos?
    0:04:22 – That’s a really good question to ask.
    0:04:24 One of the things that I’ve noticed
    0:04:27 is the distinctions between values and behavior.
    0:04:31 So rebel leaders are very, very clear on the values.
    0:04:34 The aerial investment, what the rule picked up
    0:04:37 was importance of having a good reputation.
    0:04:39 The fact that we’re always keeping our clients
    0:04:41 in our mind and we wanna make sure
    0:04:43 that all our communications are clear.
    0:04:46 Once the values really clear,
    0:04:48 you can allow more flexibility on the behaviors
    0:04:50 that are gonna get you there.
    0:04:54 And so when people are clear on the commitment
    0:04:57 that they’ve made to the leader and to the organizations,
    0:04:59 I think that they do have better judgments
    0:05:01 about how to get there,
    0:05:06 but the values should not be questioned or touched.
    0:05:07 And so for many of these businesses,
    0:05:12 integrity or being respectful or doing the right thing
    0:05:16 is an important value to sustain.
    0:05:18 And the other thing that is interesting is that
    0:05:22 in businesses where rebelliousness is encouraged,
    0:05:25 people feel trusted for what they do.
    0:05:27 And so with that, it seems that they also
    0:05:30 have a better judgment in terms of deciding,
    0:05:32 is this a time where I should show curiosity,
    0:05:35 ask questions or just get the work done.
    0:05:37 – So by very nature of having your
    0:05:40 kind of rebellious instincts allowed,
    0:05:42 you develop better judgment about where
    0:05:44 and when it is appropriate to use them.
    0:05:45 – Exactly.
    0:05:47 Some people find it paradoxical
    0:05:50 because you would expect that if we allow
    0:05:52 other people to have more control or autonomy,
    0:05:54 we’re gonna end up with pure chaos.
    0:05:55 That’s not the case.
    0:05:57 – Let’s circle back and talk about
    0:05:59 how you actually define different qualities
    0:06:01 of rebellious behavior.
    0:06:02 You kind of break it down
    0:06:05 into the core elements of rebel behavior.
    0:06:07 – I identify these characteristics.
    0:06:10 And if you think about each one of them,
    0:06:13 engaging and using that characteristic
    0:06:16 means of fighting against something.
    0:06:19 So the five categories are novelty, curiosity,
    0:06:22 perspective, diversity and authenticity.
    0:06:24 And let me define each of them quickly.
    0:06:28 Novelty is this desire to go for
    0:06:30 what’s unfamiliar and uncomfortable
    0:06:33 rather than sticking to our tendencies
    0:06:35 to go to unfamiliar and comfortable.
    0:06:37 – And rebels enjoy that precisely
    0:06:39 because it’s something new and uncomfortable.
    0:06:41 – That’s exactly right.
    0:06:43 Rebels have this incredible desire
    0:06:47 to do something that is gonna challenge them.
    0:06:48 That’s not our human tendency.
    0:06:51 Our human tendency is to go with the comfortable,
    0:06:53 the familiar.
    0:06:57 And so the rebels fight against that tendency
    0:07:01 and that common behavior and they do something different.
    0:07:05 Curiosity is all about asking questions
    0:07:07 and showing that sense of wonder
    0:07:09 that we used to have when we were little kids.
    0:07:12 In situations where most other people
    0:07:16 would just go with what is already there.
    0:07:19 Whether it’s a process, a tradition, a routine,
    0:07:22 whatever that is, they say to the status quo
    0:07:25 rather than asking questions and moving us forward.
    0:07:28 If you look at the data on how we grew up,
    0:07:30 as it turns out we’re born with a lot of curiosity
    0:07:34 and then curiosity, the data says,
    0:07:36 peaks at the age four and five
    0:07:38 and then unfortunately declines from there.
    0:07:39 – So young.
    0:07:40 – So young.
    0:07:43 So I have a three-year-old and it’s a constant question
    0:07:47 and constant asking from why is it that we need to dress
    0:07:49 when we leave the house to why is it
    0:07:50 that we need to pay for stuff?
    0:07:52 Why is it that we live on earth?
    0:07:55 The sense of wonder in approaching the world.
    0:07:58 We tend to lose that as we grow up.
    0:08:01 I was very much interested in what organizations can do
    0:08:04 to retain curiosity alive.
    0:08:08 So we had about 350 people, those sorts of jobs,
    0:08:09 measure their level of curiosity,
    0:08:12 then we sort of let them do their job
    0:08:15 as they were starting in their new ventures.
    0:08:17 We went back to them six to eight months later.
    0:08:20 And what we saw was when we measure curiosity again
    0:08:23 is that curiosity had dropped across the board
    0:08:25 by at least 20%.
    0:08:29 And that’s a signal that often we enter jobs
    0:08:32 that rather than keeping our curiosity alive,
    0:08:35 they kill our curiosity.
    0:08:38 And that’s disappointing and sad.
    0:08:40 And I see a real opportunity there.
    0:08:42 Exactly, it’s a real loss.
    0:08:44 And so why does that happen?
    0:08:47 And why is it that organizations that are not doing that,
    0:08:51 what it is that they do to in fact keep curiosity alive?
    0:08:53 And how is it different from novelty actually?
    0:08:55 Because they kind of seem like two sides
    0:08:56 of the same coin to me.
    0:08:59 Curiosity is almost the hunger for the novelty.
    0:09:02 Yeah, so they are definitely related.
    0:09:05 So in a sense, curiosity could be a precursor,
    0:09:07 if you will, to novelty.
    0:09:12 Novelty, I see it as more as stretching yourself
    0:09:15 and making sure that you put yourself in situations
    0:09:17 where there are challenges.
    0:09:19 For example, a business,
    0:09:22 I don’t think most of us would expect any novelty whatsoever.
    0:09:26 It’s a fast food chain in the middle of Tendency in West Virginia.
    0:09:28 They have about 30 stores.
    0:09:31 Their name is Pal Sudden Service.
    0:09:33 If you look at any measure of performance,
    0:09:34 revenue per square, you name it,
    0:09:36 they beat the competition by far.
    0:09:39 And we’re talking about big brands like McDonald’s,
    0:09:42 Wendy’s, Burger King’s, so they’re doing incredibly well.
    0:09:44 So if it plays like McDonald’s,
    0:09:47 you get an hour, two hours of training per station.
    0:09:52 At Pal Sudden Service, you get 135 hours of training per station.
    0:09:52 Wow.
    0:09:55 So they make people feel like experts in what they do,
    0:09:58 thinking that that is going to give them some free space
    0:10:00 in their mind to innovate or think creative
    0:10:02 about how to improve on their jobs.
    0:10:05 But what’s interesting is that I was in the stores,
    0:10:11 so these are big blue boxes with fries and hot dog on their roofs.
    0:10:13 The work at rush hours is pretty impressive.
    0:10:15 Every worker is working really fast,
    0:10:18 and you would think that the job that you’re doing
    0:10:21 becomes monotonous, it becomes a routine.
    0:10:24 And the general managers at each of the stores have thought about that.
    0:10:27 And so they give people the way in which
    0:10:30 they can experience novelty on a day-to-day basis.
    0:10:33 Every worker moves according to a shift
    0:10:35 from station to station throughout the day,
    0:10:37 but they actually learn about the order
    0:10:39 that they’re going to follow for a specific day
    0:10:40 when they show up for work.
    0:10:41 They don’t know it.
    0:10:43 It’s a surprise, it’s unpredictable.
    0:10:45 And what is interesting is that that’s just a small way
    0:10:47 in which I challenge you for novelty.
    0:10:49 So that’s, I think, a clear example
    0:10:54 where novelty is at stake rather than curiosity, per se.
    0:10:55 Yes, interesting.
    0:11:00 Perspective is about fighting that tendency that we all have
    0:11:04 to come to situations or problems with only one view.
    0:11:06 So Chef Massimo Boutoura owns this restaurant
    0:11:08 called the Stria Francesca.
    0:11:10 And it’s a three Michelin star restaurant.
    0:11:13 Once a week, he asked one person on his staff
    0:11:15 to cook the stuffed meal.
    0:11:17 And his stuff is very diverse.
    0:11:22 So people from Mexico, Canada, United States, Japan, Italy.
    0:11:25 And so what he is trying to accomplish
    0:11:28 with what seems to be a very simple ask or move
    0:11:31 is to show that the same ingredients
    0:11:34 is used very differently across all sorts of recipes
    0:11:36 because of the culture people grew up in.
    0:11:40 And so it’s just a small way to inject that view
    0:11:42 that the world is bigger
    0:11:44 or that a certain situation is bigger
    0:11:47 than just our own perspective.
    0:11:50 And that is worth looking and coming into situations
    0:11:53 from multiple angles or with multiple views.
    0:11:58 Diversity is about not accepting social roles
    0:12:01 that are often passed upon us.
    0:12:07 So having stereotypical views or using bias in situations
    0:12:11 where instead we should come to appreciate differences.
    0:12:14 One of the things that rebels do when it comes to diversity
    0:12:18 is really looking at it as an opportunity
    0:12:21 to explore and leverage difference.
    0:12:22 And finally, we have authenticity.
    0:12:26 Authenticity is all about being able to bring our voice
    0:12:29 into the conversation, our contributions forward,
    0:12:33 not being afraid of expressing our views, preferences,
    0:12:34 and thoughts.
    0:12:37 And so there we are fighting the tendency
    0:12:40 that is so powerful and strong of conforming to others.
    0:12:43 So think about last time you were in a meeting,
    0:12:46 everybody else was thinking that X was the right course
    0:12:50 of action, and you were the person who disagreed,
    0:12:53 and you had the courage and willingness
    0:12:56 to speak about your views.
    0:12:58 And so you showed authenticity by bringing
    0:13:00 your contributions forward.
    0:13:03 All of these, in some ways, I think
    0:13:06 we were saying a moment ago, are kind of about fighting
    0:13:11 stagnation or the comfort of thinking you know.
    0:13:15 You talk about surgeons who are deep experts in their field
    0:13:20 being less willing to be open to new information
    0:13:24 by virtue almost of their expertise
    0:13:27 than younger, less experienced people.
    0:13:30 What’s the relationship between the sort of like,
    0:13:33 I’m becoming an expert because I’ve learned so much
    0:13:38 and that frees me up to innovate more versus I settle
    0:13:41 into my expertise and become more shut down
    0:13:44 to sort of new perspective, new experience.
    0:13:46 Yeah, you could imagine situations
    0:13:48 where you become an expert, but you completely
    0:13:50 have zero curiosity.
    0:13:53 What that means is that you use your experience
    0:13:56 to say, I have all the answer.
    0:13:58 And instead, effective rebels are people
    0:14:02 who accumulate their experience, but they still
    0:14:05 approach the world thinking that their perspective might
    0:14:08 be not necessarily the right perspective to use
    0:14:09 to look at a problem.
    0:14:14 I got very fascinated by this idea
    0:14:16 that experience could lead to trouble.
    0:14:19 We collected this quite incredible data set
    0:14:23 where basically we were looking at the behavior of surgeons
    0:14:25 in open arms for surgeries, what kind of technology
    0:14:27 they were using.
    0:14:30 And we exploited the fact that the Food and Drug Administration
    0:14:35 back in 2006 put out an announcement that said basically
    0:14:39 the technology that you’re using is not good for the patients.
    0:14:42 And we were able to see whether the surgeons changed
    0:14:45 their behavior, now knowing that what they were doing before
    0:14:47 was not good for their patients.
    0:14:51 And what we found is that the more experience the surgeon had,
    0:14:53 the less likely they were to change their behavior.
    0:14:55 And so that’s a situation where experience
    0:15:00 is used as a sign of confidence that you have the right answer.
    0:15:05 And instead, rebel leaders, or rebels more generally,
    0:15:08 use their experience but always approach
    0:15:11 the world with a curiosity that allows you to say,
    0:15:15 what could be different here or what could I still learn?
    0:15:17 So it’s the combination of all these different factors.
    0:15:18 That’s exactly right.
    0:15:20 It’s not just ticking a box.
    0:15:22 It strikes me that all of these rebels
    0:15:26 that you described had a clear understanding of the rules
    0:15:28 before they decide to break them, right?
    0:15:30 There is an enormous amount of assimilating of knowledge
    0:15:33 coupled with this kind of willingness
    0:15:37 to re-examine, to not have that turn into stagnation.
    0:15:42 You said wisdom means rejecting the feeling of knowing.
    0:15:44 I thought that was so interesting
    0:15:47 that there’s something in and of itself about knowing
    0:15:52 that almost stops the accumulation of more knowledge.
    0:15:56 It’s having more knowledge, but we did also more humility.
    0:15:59 So you know, you realize that the more you know,
    0:16:02 is not that the more you know, is the more you know,
    0:16:06 the more you know, the more there is something left
    0:16:08 to discover and acquire.
    0:16:11 One person that really brought this home
    0:16:13 is Captain Sally Sullenberger.
    0:16:16 He’s the person who was back on a cold evening in 2009,
    0:16:19 ditched a plane in the Hudson River.
    0:16:22 You have a person who had 208 seconds.
    0:16:25 So that’s the time he had from when he discovered
    0:16:26 that there was no thrust in the engine
    0:16:28 at the time he ditched the plane in the Hudson River.
    0:16:30 So very little time.
    0:16:33 And yet he considered all sorts of options.
    0:16:36 What we know from psychology is that most of us,
    0:16:40 under such pressure and such level of anxiety and stress,
    0:16:44 would narrow our thinking, narrow our perspective.
    0:16:45 We didn’t.
    0:16:47 He kept asking what it is that I could do.
    0:16:49 And so I reached out to him.
    0:16:52 I was totally fascinated by reading the report.
    0:16:55 And one of the things that I discovered is that
    0:16:57 by the time the accident happened,
    0:16:59 he had a ton of experience.
    0:17:01 Over 30,000 hours of flying experience.
    0:17:02 He served in the military.
    0:17:05 So he knew how to fly all sorts of planes.
    0:17:09 He has served as a volunteer in previous accidents
    0:17:11 to study what went wrong.
    0:17:13 So he had a lot of knowledge about what can actually
    0:17:15 go wrong on a plane.
    0:17:17 And yet every time he walked into the cockpit,
    0:17:20 he would ask himself what it is that could be different here.
    0:17:22 He forced himself to come at it from a different angle
    0:17:24 every time.
    0:17:25 So that became habit.
    0:17:26 Yes.
    0:17:30 And it’s him having experience plus that intellectual
    0:17:34 humility that allows you to say, but what could?
    0:17:36 Or what’s left to learn?
    0:17:39 You talk specifically about vulnerability,
    0:17:42 being willing to open yourself up.
    0:17:45 And what that communicates to others.
    0:17:48 It’s not just a kind of building of trust.
    0:17:50 It’s actually doing something else as well.
    0:17:52 Can you talk a little bit about what that does,
    0:17:53 that vulnerability?
    0:17:53 Yeah.
    0:17:59 So part of being authentic is being willing to make yourself
    0:18:00 vulnerable.
    0:18:03 And there is this story that I share in the book about a coach
    0:18:05 called Maurice Cheeks.
    0:18:10 We’ll go back to April, 2003, where prior to the game
    0:18:13 starting, a girl went up in the middle of the arena
    0:18:15 to sing the national anthem.
    0:18:19 And so imagine 20,000 fans ready to watch the game,
    0:18:21 millions of viewers from home.
    0:18:25 And is there listening to the girl singing as everybody else?
    0:18:30 And by the time the second sentence in the song arrives,
    0:18:32 the girl can’t remember the words.
    0:18:35 And what you see in the video clip of this moment
    0:18:40 is that the coach went to her, put an arm around her,
    0:18:42 and helped her sing.
    0:18:44 When I read this story in your book,
    0:18:46 I have to say I welled up a little bit.
    0:18:48 It was very, very moving.
    0:18:49 Yeah, very, very moving.
    0:18:51 But what is interesting is that if you actually listen
    0:18:55 to the clip of the moment, his voice sucks.
    0:18:55 I’m sorry.
    0:18:57 There is no better way of describing it.
    0:19:02 And so it’s a great example of a person who put himself out
    0:19:05 there without too much thinking and really showing
    0:19:09 everybody, millions of viewers, thousands of fans.
    0:19:12 That voice is clearly not one of his strengths.
    0:19:13 And what is beautiful about the moment
    0:19:15 is exactly what you said.
    0:19:18 Unless you have no heart, you actually feel moved.
    0:19:22 And you feel a great sense of respect for the coach.
    0:19:26 And it’s a great example of how often our idea is about what
    0:19:30 it is that is going to bias respect from others or influence.
    0:19:33 We think that we need to show our perfect self to others.
    0:19:34 And that’s not true.
    0:19:37 Making ourselves vulnerable buys us respect.
    0:19:39 That’s so interesting.
    0:19:42 Is the willingness of people of leaders
    0:19:44 to show that they have weaknesses,
    0:19:47 to talk about their failures, or to talk about situations
    0:19:50 in which they didn’t do the right thing.
    0:19:52 We have this sense, again, of showing ourselves
    0:19:55 as the perfect individual to others.
    0:19:58 And it’s actually something that becomes stronger
    0:20:00 when we become leaders.
    0:20:04 Because we feel as if now we’re in a position where
    0:20:05 we’re leading the course for others.
    0:20:08 And it’s really the wrong idea.
    0:20:11 Since it’s when we open up, talk about potential failures,
    0:20:14 bad decisions, that people really relate to us.
    0:20:17 And they look at us and say, you are actually a human being.
    0:20:20 And there is a way I can trust you, respect you for what
    0:20:22 you’re doing, and also for the mistakes you’ve made.
    0:20:25 It seems that so much of this requires
    0:20:27 a level of self-reflection.
    0:20:31 To me, that was almost one of the missing categories here.
    0:20:33 Or maybe underlying all of those categories
    0:20:39 is the ability to know yourself and to be always trying
    0:20:42 to notice your own patterns and your tendencies
    0:20:45 and then push them in one direction or another.
    0:20:48 Can you talk a little bit about how these rebels tend
    0:20:52 to handle the self-knowledge part?
    0:20:55 If you put authenticity and perspective together,
    0:21:00 those two capture this idea of stopping, reflecting,
    0:21:05 being aware of your own self and how you interact with others.
    0:21:07 One of the things that makes us feel authentic
    0:21:11 is knowing where the energy comes from and what you do.
    0:21:14 And playing to our strengths is something
    0:21:17 that we don’t put time in our calendar for.
    0:21:19 So some of the interventions that we’ve
    0:21:21 done in organizational context is
    0:21:23 give people that time for reflection.
    0:21:24 Oh, interesting.
    0:21:27 So we did a big study in India, where
    0:21:31 at the time of welcoming people to the organizations,
    0:21:35 we asked a group of them to reflect on what their strength
    0:21:38 was, what is unique about them, and how they could bring those
    0:21:39 out in the work that they do.
    0:21:42 And this is people going to work in a call center.
    0:21:44 So where you pack the job to be scripted.
    0:21:47 And it’s focused on the positive, the strengths, the not
    0:21:48 that I need to do better at this.
    0:21:49 That’s right.
    0:21:53 And what we saw was increased performance, increased job
    0:21:55 satisfaction, increased engagement,
    0:21:57 and better retention rate.
    0:22:00 And sometimes it’s not you reflecting on your strength.
    0:22:04 It’s actually us going out to people
    0:22:09 and asking them for stories of you at your best.
    0:22:13 It’s so powerful when you feed those stories back to you,
    0:22:15 because you see that you’re making contributions
    0:22:18 that you have no clue of.
    0:22:20 And you start creating your own profiles
    0:22:23 of who you see yourself to be as a person.
    0:22:25 And it is sort of like the hardest thing
    0:22:28 that we as human beings can possibly do, right?
    0:22:32 All of life is training us deeper into our own little
    0:22:33 tributaries.
    0:22:36 And you’re accumulating the knowledge that makes you you.
    0:22:39 But it becomes hard to shift out of that.
    0:22:42 What are some of the other ways in which,
    0:22:45 either on an organizational level or on a personal level,
    0:22:48 that you can encourage the resistance to stagnation,
    0:22:50 basically?
    0:22:54 There is a technique that is used in brainstorming sessions.
    0:22:58 The entire technique, really, is built on something
    0:23:01 that is very core to improve comedy, which
    0:23:03 is the idea of the yes and.
    0:23:04 So every time we have a discussion,
    0:23:07 every time we have a meeting, every time we talk about decisions,
    0:23:10 the idea is that I come into it with my perspective,
    0:23:14 but with also the willingness to accept the view of others.
    0:23:17 So let’s imagine you’re working on a scene.
    0:23:23 And I come in and say, oh, this is a really yummy apple.
    0:23:25 And you come in after me and say, no,
    0:23:27 this is a small melon.
    0:23:30 Maybe you got a laughter from the people in the audience,
    0:23:32 but you just killed a scene.
    0:23:36 And what improv is all about is accepting whatever ideas
    0:23:39 is put on the table and then adding to it, building onto it.
    0:23:45 So passing is exactly built around the same ideas of I accept
    0:23:48 the idea, I might disagree with it,
    0:23:51 but I’m going to take that for granted and then build on it.
    0:23:54 And so if you think about how we interact with one another
    0:23:59 or how we get to do our work with others,
    0:24:02 often, passing is not what we do.
    0:24:04 So you see lack of perspective in people
    0:24:07 who say who shut down ideas that others have suggested.
    0:24:11 Or even just debating them is not plusing.
    0:24:14 It’s like staying where you are and kind of pulling it apart.
    0:24:16 That’s exactly right.
    0:24:18 Well, that reminds us of is to show perspective,
    0:24:21 to show curiosity, to come to the table,
    0:24:24 eager to learn from others.
    0:24:28 I’ve been in way too many meetings as an observer
    0:24:33 where what you see is people just bringing in their own views,
    0:24:34 their own decisions.
    0:24:37 Or as you’re talking, I’m already formulating.
    0:24:39 My answer without really paying attention to you.
    0:24:43 And so this idea of showing up with curiosity,
    0:24:46 with perspective, with your eyes open to learn
    0:24:51 is a good principle that drives a lot of rebelliousness
    0:24:55 and organizations that really embrace these ideas.
    0:24:56 It’s interesting because it almost sounds
    0:24:59 like you’re describing being present.
    0:25:00 And it’s difficult to do.
    0:25:04 And sometimes you fight against your own beliefs.
    0:25:05 Like one of the things that I’ve done
    0:25:10 is to be more reflective about my own approach to work,
    0:25:11 my own leadership, if you were.
    0:25:14 But also my behavior back at home.
    0:25:15 So I have three small children.
    0:25:19 And if you were in my house, usually around 6
    0:25:23 AM when people are starting to wake up,
    0:25:25 as I’m making my coffee, usually two of my children,
    0:25:28 if not three, are running around the kitchen,
    0:25:29 opening cabinets.
    0:25:32 And I used to stop that behavior because I thought
    0:25:35 that you would end up in chaos, that they would never
    0:25:36 get to work.
    0:25:40 And after actually learning more from these rebels,
    0:25:43 I joined in their explorations and asked them questions.
    0:25:47 And I have to tell you that I’ve not arrived late at work
    0:25:49 because I allowed those explorations to happen.
    0:25:54 And I think I can think of one where my third is a year and a half
    0:25:55 found the salt.
    0:25:58 And she was shaking the salt like a priest in the kitchen.
    0:25:59 And so there was salt on the floor.
    0:26:01 But the entertainment value of that
    0:26:05 was bigger than the cleaning up of the mess.
    0:26:08 That’s so interesting because I’m also remembering
    0:26:10 and thinking of all of our mornings
    0:26:14 and thinking of how much there is pressing down on you
    0:26:18 to shut all those things down because then none of us
    0:26:19 will ever get to school on time.
    0:26:23 You do have to re-evaluate and then
    0:26:27 notice those pre-programmed responses
    0:26:30 and then choose to swim upstream from them.
    0:26:31 And I really liked in the section
    0:26:35 where you talked about changing your own behavior
    0:26:39 but also that your own behavior towards others
    0:26:43 as part of your own expectations actually changes things.
    0:26:45 So the first one seems kind of obvious, right?
    0:26:47 But the second one that you actually
    0:26:52 are setting change in motion just by changing your expectations
    0:26:54 because of what it does to your own behavior
    0:26:55 is really interesting.
    0:26:58 Yeah, I was talking about some work
    0:27:01 done on the pychmalium effect.
    0:27:05 And what this research shows is that our expectation actually
    0:27:08 leads us to pay a different amount of attention
    0:27:13 to the people that we code to be good workers versus bad workers
    0:27:16 or lazy people versus contributors.
    0:27:21 And our expectations also lead them to behave differently.
    0:27:23 Because if we have higher expectations,
    0:27:26 people actually rise up to the challenge
    0:27:30 and in fact become the productive people we expect them to be.
    0:27:33 But how are those signals being transmitted?
    0:27:35 Because you think you’re keeping it to yourself.
    0:27:37 And we don’t.
    0:27:39 So imagine situations where you’re the teacher
    0:27:42 and I come and tell you this students in your class
    0:27:44 from the test that we ran are going
    0:27:47 to be having the greatest growth potential
    0:27:49 and these other students are average.
    0:27:52 And so what the studies showed is two things.
    0:27:56 First, that the students you randomly
    0:27:59 were chosen to be the good students or students that
    0:28:02 ended up performing better at the end of the semester.
    0:28:05 But also that your behavior towards them changed.
    0:28:07 Where is it that you spend most of your attention?
    0:28:10 Who did you give the benefit of the doubt to?
    0:28:13 And so you’re reinforcing their ability to actually rise up
    0:28:14 to the challenge.
    0:28:17 And that is not different in work context.
    0:28:22 As leaders, if I start off by saying that you’re OK, maybe
    0:28:25 an average person working in my business versus I
    0:28:27 know that you have this talent, I’m
    0:28:29 much more likely to give you the benefit of the doubt.
    0:28:32 To be there giving you constructive feedback when
    0:28:34 you need it, to help you out when you face challenges.
    0:28:39 And so you, in fact, end up being in the category
    0:28:40 of the greatest performer.
    0:28:42 That reminds me of where you talk
    0:28:46 about what it means to hide certain feelings, right?
    0:28:48 That when someone hides their feelings,
    0:28:50 those who interact with him experience
    0:28:52 a rise in their blood pressure.
    0:28:56 Not only is the cost of that kind of lack of authenticity
    0:28:59 on you, but there’s also just a simple cost
    0:29:01 to just the hiding of them.
    0:29:02 Is that right?
    0:29:02 Exactly.
    0:29:05 It comes back to a very simple notion,
    0:29:11 which is we seem to have misplaced, mistaken predictions
    0:29:14 about what is going to generate the best interactions
    0:29:15 with others.
    0:29:17 Whether I work or in life more generally.
    0:29:19 So with authenticity, often we think, well,
    0:29:22 we don’t want to show ourselves to others.
    0:29:23 Let’s cover up.
    0:29:25 A lot of research shows that not only, as you said,
    0:29:28 we feel bad about it, because in authenticity,
    0:29:29 it doesn’t feel good.
    0:29:31 It creates a lot of discomfort.
    0:29:33 In fact, people associate it, in a lot of cases,
    0:29:37 as feeling tainted because they’re covering up
    0:29:38 and being deceitful.
    0:29:41 But it’s also picked up by others.
    0:29:43 OK, so almost by definition of what
    0:29:45 you’re talking about being rebellious
    0:29:48 has this kind of idea of conflict at heart behind it,
    0:29:51 that you’re not afraid of conflict
    0:29:53 or that you introduce conflict.
    0:29:56 Can you talk about a little bit how rebels tend
    0:29:59 to handle conflict or create it around them
    0:30:03 and how the people around them respond to it?
    0:30:05 You’re going to end up with more conflict
    0:30:07 because people are coming in and willing to state
    0:30:11 their contributions or bring their ideas forward,
    0:30:13 and then they’re going to debate them.
    0:30:16 But the characteristics that is really important there
    0:30:18 is the fact that we are disagreeing,
    0:30:22 but again, from a point of acceptance of each other’s
    0:30:22 views.
    0:30:24 So the conversation doesn’t become one
    0:30:28 where I need basically to prove that I’m right.
    0:30:32 It’s coming in thinking I need to come to a good decisions,
    0:30:35 and I’m going to be willing to stay open-minded and receptive
    0:30:38 to what other people are actually saying.
    0:30:39 Sounds like a good marriage.
    0:30:41 That does sound like it.
    0:30:47 And it’s so, I think, easy to say, but difficult to do.
    0:30:50 This Chicago-based money management firm,
    0:30:55 the leaders themselves call out the lack of conflict
    0:30:56 in given situations.
    0:31:02 So for example, there is one known phrase at the company.
    0:31:04 One of the leaders there, Melody Obeson,
    0:31:06 who’s the president, would stand up and say,
    0:31:08 it’s time to make the donuts.
    0:31:14 And it’s this reminder of an old ad at Dunkin’ Donuts,
    0:31:17 where you see Fred the Baker wake up in the morning,
    0:31:19 go to work, to make the donuts.
    0:31:21 The day after, he would do the same thing.
    0:31:22 The day after, he would do the same thing.
    0:31:25 And so it’s reminding people that it’s very easy to just go
    0:31:27 with the flow and have no conflict,
    0:31:29 no disagreement about anything.
    0:31:33 And so she snaps people out of that mode
    0:31:36 and remind them of the importance of actually pushing
    0:31:38 each other and challenge each other’s points of view.
    0:31:41 So her point is, essentially, we’re making donuts, right?
    0:31:42 Exactly.
    0:31:44 OK, for all the people building companies,
    0:31:47 as you’re building a culture in a new company,
    0:31:50 wanting to, yes, encourage kind of free thinking
    0:31:53 and encourage creativity, but we need things
    0:31:54 to be smooth on some level.
    0:31:56 So how do you balance those two things
    0:31:59 when you’re building something from the very beginning?
    0:32:03 So to me, it goes back to this idea of values.
    0:32:05 And you want people really committed to the values.
    0:32:08 But then, how they get there, or how is it
    0:32:11 that they embrace the value, it’s OK for people
    0:32:14 to have different ways of doing just that.
    0:32:18 If you look at what we know in terms of level of engagement
    0:32:22 in the workforce, the data is saddening.
    0:32:23 It’s really upsetting, in a sense,
    0:32:27 because most workplaces have 2/3 of their people
    0:32:28 being disengaged.
    0:32:33 And so what I saw in these labels is this full engagement
    0:32:37 with life, whether it’s life at work, life at home,
    0:32:40 and they seem to be making most out of it.
    0:32:42 We are much more engaged in the work that we do.
    0:32:44 We are more productive.
    0:32:46 We end up having more creative or innovative ideas.
    0:32:50 And so if anything, the question is, why not?
    0:32:52 We should definitely make sure that there
    0:32:54 is more rebelliousness in our life.
    0:32:56 That’s very inspiring.
    0:32:59 Thank you so much for joining us on the A16Z podcast.
    0:33:01 Thank you so much for having me.

    When we think about rebellious behavior in the context of organizations and companies, we tend to think of rebels as trouble-makers, rabble-rousers; in other words, people who make decisions and processes more difficult because they may not follow the established rules or norms. But rebel behavior can also be incredibly positive and constructive—in keeping us from stagnation, encouraging growth and learning, increasing curiosity and creativity.

    In this episode of the a16z Podcast, Harvard Business School Professor Francesca Gino, a social scientist who studies organizations, breaks down with a16z’s Hanne Tidnam what makes rebels different in how they tend to see and do things—whether that’s cooking, flying planes, or holding board meetings—and what we can all learn from “rebel talent” to make our organizations more productive and innovative.

  • All about the Coronavirus

    AI transcript
    0:00:04 Hi, everyone. Welcome to this week’s episode of 16 Minutes, where we cover what’s going
    0:00:08 on, what’s in the news from our vantage point in tech. In this episode, we’re going to
    0:00:13 go deep on one topic, which is the coronavirus, and it’s a very fast-developing news cycle,
    0:00:17 so we’re going to take a snapshot for where we are right now. And since this show is all
    0:00:21 about teasing apart what’s hype, what’s real, given all the buzz and headlines out there,
    0:00:24 we’re going to try to focus on what we know and what we don’t know. I’ve tried drawing
    0:00:30 wherever possible from primary sources, so CDC reports, World Health Organization reports,
    0:00:35 etc., instead of only looking at news headlines and derivative reports. And our ASICs and
    0:00:38 the expert, who I’ll introduce in a moment, will be bringing in the vantage point coming
    0:00:41 from bioengineering and that aspect as well.
    0:00:45 So first of all, let me quickly summarize the news. People are referring to this outbreak
    0:00:50 as the coronavirus, but it’s actually a new type of coronavirus because coronavirus is
    0:00:55 actually the general term for a more common category of viruses. And this current strain
    0:01:03 is called 2019-NCOV for 2019-N novel coronavirus. It’s a rapidly developing situation, but
    0:01:10 as of January 26, according to the situation update on the World Health Organization website,
    0:01:16 there’s a total of 2014 confirmed cases that have been reported globally. Of these, 98%
    0:01:24 were reported from China, including Hong Kong, Macau, and Taipei. 324 of 1,975 cases have
    0:01:30 been reported as severely ill, with 56 deaths reported to that date. Finally, 29 confirmed
    0:01:35 cases have been reported out of China in 10 countries, and in the table that the World
    0:01:40 Health Organization provided, there’s two cases listed in the US, but there’s more.
    0:01:43 Again, this is from the Six Situations Report, which comes out every few days, and this one
    0:01:47 came out on Sunday, January 26. That’s a very high-level summary. Now, let me welcome Judy
    0:01:52 Sovitzkaya on the A6nz BioDeal team. First of all, really quickly, what is it? What is
    0:01:53 the coronavirus?
    0:02:00 Yeah, so let’s discuss what even is a virus. So a virus is basically a bunch of DNA or
    0:02:05 RNA, some sort of nucleic acid, surrounded by a protein shell called the capsid of the
    0:02:09 virus. That is the entire organism. And a lot of people actually don’t even call this
    0:02:13 an organism because it’s not quite alive and it’s not quite dead. It’s something in
    0:02:14 between.
    0:02:17 There’s kind of a debate in the scientific community and the philosophical community
    0:02:22 about what is a living thing. And the place where most people have come down is that you
    0:02:27 need two conditions to be alive. You need to metabolize, which means you’re taking some
    0:02:31 chemicals, transforming them into other chemicals, and pulling out energy in the process and
    0:02:37 using that energy for something. And the second requirement for a living thing is to multiply,
    0:02:43 to reproduce. So viruses really only satisfy the second condition. They don’t do anything
    0:02:47 on their own. They don’t… Outside of a human host, they are non-living.
    0:02:52 So that’s why there’s such a debate. The bottom line is that they don’t metabolize, but they
    0:02:53 do multiply.
    0:02:54 Exactly.
    0:02:58 So tell me now more about the coronavirus category.
    0:03:04 So the reason it’s called coronavirus is because on electron microscopy images, it actually
    0:03:09 looks like there’s a little crown around the virus. The capsid for the coronavirus has
    0:03:14 these proteins on it that are spikes. And a lot of the ways that we’re developing vaccines
    0:03:17 against this virus and a lot of the ways that we’re identifying different types of these
    0:03:21 viruses is by characterizing those spike proteins.
    0:03:26 And as with most things in biology, we use Greek symbols to denote different versions
    0:03:30 of the coronavirus. So there’s the alpha, the beta, the delta, and the gamma, which
    0:03:36 are kind of four of the main categories of coronavirus. A lot of the common viruses are
    0:03:39 either alpha or beta types, but SARS and MERS, they’re all betas.
    0:03:43 Okay. So that’s kind of scientifically what it is. Now let’s practically break down the
    0:03:48 symptoms. According to the CDC, the symptoms can include fever, cough, shortness of breath,
    0:03:53 or other respiratory symptoms. And they believe that at this time, that symptoms of this virus
    0:04:00 may appear in as few as two days or as long as 14 days after exposure. And this is actually
    0:04:04 similar to what’s been seen with the previous incubation period of MERS viruses. And I’ll
    0:04:08 get to what that is in a minute. But unlike those viruses, this particular one rarely
    0:04:13 produces obvious like runny noses or intestinal symptoms necessarily, just according to one
    0:04:18 report and that was recently published in Lancet. So I guess the question is that all
    0:04:21 of these things are on a continuum. It’s not very discreet. Like this is all symptoms that
    0:04:24 can describe frankly, any common cold, right? It’s the WebMD problem.
    0:04:28 Right. Basically, you can Google it and find, associate yourself with anything. So the question
    0:04:34 I have is, how does this stack up against MERS and SARS? And just really quickly to
    0:04:39 summarize, SARS was the acronym for severe acute respiratory syndrome. There’s a big
    0:04:44 outbreak of it in the early 2000s. And then MERS is Middle East respiratory syndrome.
    0:04:49 And that is new as of 2012. So coronaviruses cause about 10 to 30% of colds, just your
    0:04:54 common colds. And those are not nearly as serious as this disease. And some of the differences
    0:05:00 between these epidemic causing coronaviruses versus your common cold is just the severity
    0:05:04 of the infection, the likelihood that you are to die or to have really serious complications
    0:05:10 from the infection. And in all of these cases, SARS, MERS, and this current coronavirus,
    0:05:15 it’s because the coronavirus is infecting the lower part of the respiratory tract versus
    0:05:17 just staying around your upper respiratory tract area.
    0:05:21 Right. So not just your mouth, nose and sinuses, but by going into your lungs. So just like
    0:05:26 a quick summary of where the fatality rates are, SARS apparently claimed about 10% of
    0:05:32 people and MERS was much worse, claiming 30% of the people it infected. It’s also interesting
    0:05:35 because I’ve been reading a lot of papers, but none of them are peer reviewed. In fact,
    0:05:40 one of the papers between Friday and today was already updated with V2, but the authors
    0:05:44 of the local institutes of virology, Chinese Academy of Sciences, local hospitals and the
    0:05:50 provincial CDCs in China within this area supposedly analyze full length genome sequences
    0:05:54 from five patients at the early stage of the outbreak. And they found that almost all of
    0:05:59 those were identical to each other. So it’s the same virus and B, that about 79.5%. And
    0:06:05 again, this is the current paper still being updated, identify to SARS coronavirus.
    0:06:08 So that’s actually the most interesting thing from a bioengineering perspective about this
    0:06:14 particular epidemic is how incredibly quickly we have sequenced this virus for past epidemics.
    0:06:19 It’s taken time for us to really understand the genome and the molecular nature of a given
    0:06:23 virus that’s causing an epidemic. In this case, within two weeks, people had already
    0:06:29 published draft versions of the genome sequence for this virus. And the science is happening
    0:06:34 in the sort of really live way that doesn’t happen very often where people are commenting
    0:06:36 literally in the GenBank on the GenBank website.
    0:06:40 The CDC uploaded the entire genome of the virus from the first reported case in the
    0:06:44 United States to GenBank. And it’s also interesting because in the age of social media, which
    0:06:50 cuts both ways virally, it’s also spreading information much faster. Coronavirus was first
    0:06:54 detected in Wuhan city in the Hubei province in China, beginning with 44 patients who had
    0:07:00 quote, pneumonia of unknown etiology or unknown cause between New Year’s Eve and the first
    0:07:05 couple of days of 2020. And then was identified as a new type of virus isolated by Chinese
    0:07:10 authorities on January 7. And then on January 11 and 12, the World Health Organization received
    0:07:14 detailed information from the National Health Commission in China that the outbreak is associated
    0:07:21 with exposures in one seafood market in Wuhan city. And basically it’s showing the spread
    0:07:26 of information. Whereas with the SARS crisis, journalist Helen Branswell at Stat News was
    0:07:31 commenting because she had covered the SARS crisis in 2003, that one might be tempted
    0:07:35 to say SARS start was worse, it spread faster, not sure that’s true. SARS was well underway
    0:07:40 for at least 4.5 months before the world knew there was a new virus spreading. This current
    0:07:44 coronavirus seems to have been spotted much, much sooner after its emergence. But what’s
    0:07:47 really interesting is not just that it’s been spotted sooner, but that the genetic
    0:07:53 information we have is moving much faster. So can you talk to me about what that tells
    0:07:54 us and why that matters?
    0:07:58 So there’s a couple of areas where you get benefits from having all this genetic information
    0:08:03 so quickly. The first is just diagnosis. So if tomorrow somebody in San Francisco was
    0:08:07 to go into an urgent care clinic and say that they have a cold, we could really quickly
    0:08:12 identify whether or not that actually belongs to this epidemic.
    0:08:16 Another advantage we have once we have the genome sequence is that in this age of genomic
    0:08:20 medicine that we’re entering, where we’re actually creating vaccines that are based
    0:08:26 on genome sequences. The third implication is for figuring out treatments and also predicting
    0:08:30 some of the features of the epidemic. So we know in this example that this coronavirus
    0:08:35 looks really similar to SARS. So we can look back at the SARS epidemic, understand how
    0:08:39 quickly it’s spread, in which populations. And from the genomic information, you can
    0:08:44 actually see, for example, the spikes on the corona, which are involved in getting into
    0:08:49 cells, do those look similar to what the SARS spikes look like? And maybe the treatments
    0:08:51 that work in this case as well.
    0:08:54 So the high level summary is that having the genomic information, which we didn’t have
    0:08:59 then when we do have now, by then I mean the SARS outbreak, which happened about 2002 to
    0:09:05 2004, the peak was 2003, is that you can classify things much more easily, figure out where
    0:09:10 it belongs, it doesn’t belong, kind of isolate that, that you can develop things faster based
    0:09:14 on it, although there isn’t a vaccine yet, and that you can figure out treatment protocols
    0:09:17 based on the similarities and differences.
    0:09:21 Was there anything else on the connection between mayors and SARS from a genomics perspective?
    0:09:26 Yeah. So because the science is happening live, you’re seeing a lot of pretty quick modifications
    0:09:31 to what people have already said. So the first paper analyzing the genome of this virus that
    0:09:38 I saw at least, described that the spike proteins that are used to enter into lung cells are
    0:09:42 different enough between SARS and this new coronavirus, that they thought it wouldn’t
    0:09:47 be as bad as SARS. And then within like literally two days, I think I saw a paper that corrected
    0:09:51 that and said that actually the protein is quite similar at the protein level.
    0:09:54 Are there any bioengineering implications of that? This goes to me that the eternal
    0:09:58 question of how DNA expresses itself practically in the complexity of disease.
    0:10:02 That’s a really good question. This mirrors everything in genomics where we thought that
    0:10:05 once we have the sequence, we’ll know all the answers. And that’s definitely not the
    0:10:09 case. We can know from the DNA what the difference is going to be in the protein. That’s one
    0:10:13 to one, there’s no guessing there. But once we know what’s different about the protein,
    0:10:18 we don’t yet know quite what that means for how it will behave. So we don’t know if that
    0:10:23 difference means it’s stronger or it’s weaker or if it will infect different cells or what
    0:10:24 that’s going to mean.
    0:10:28 So now let’s move on to more of the details of how it spreads and the measurements of
    0:10:33 that spread. So first note is that generally the coronavirus has spread through air. They’re
    0:10:39 known as zoonotic in that they originate in animals and only sometimes leap to humans.
    0:10:43 And there’s been some speculation that this one seemed to originate in bats, but it’s
    0:10:48 usually indirect mechanisms. So in mayors, it went from bats to camels before going to
    0:10:52 humans. And a couple of papers have commented on the similarity of this new virus to bat
    0:10:58 DNA. Like one found that it’s 96% identical. Another journal of medical virology also
    0:11:02 observed similar components, but suggested snakes and many other people are skeptical
    0:11:06 of that. The long story short is no one really knows, despite having some genomic information
    0:11:07 around it.
    0:11:11 But it’s interesting to note that important epidemics come from animal sources and some
    0:11:15 speculation about the reason for that is that the viruses have time to evolve in their animal
    0:11:19 hosts and they’re evolving away from what human hosts have seen before and what their
    0:11:21 immune system has been able to recognize before.
    0:11:27 So then let’s talk about the spread. A lot of the articles are talking about R0 or R0.
    0:11:28 What does it measure?
    0:11:33 So R0 is essentially the number of people that you would expect to get infected from
    0:11:34 any single case of infection.
    0:11:37 So if the R0 is say five, what does that mean?
    0:11:41 That means that you should expect that on average, five people will get sick from one
    0:11:45 single person that they come into contact with. So for every person that has the disease,
    0:11:47 five additional people get the disease.
    0:11:52 And interestingly, these are reported as ranges. So like measles has an R0 of 12 to 18.
    0:11:57 Yeah. So measles is super infectious. It’s known as sort of the highest or one of the
    0:12:01 highest infectiousness variables, which is why it was so important to have vaccines and
    0:12:03 herd immunity for measles specifically.
    0:12:08 And the reason that it’s reported as ranges is because they depend on the particular population
    0:12:10 and the particular moment in time.
    0:12:15 So then let’s just talk about some of the facts of the spread. So the 29 exported cases reported
    0:12:21 by the World Health Organization, 26 had a travel history from Wuhan city in China.
    0:12:24 And then for two of the three cases that were identified in countries outside of China,
    0:12:29 one in Australia had direct contact with the confirmed case from Wuhan while in China.
    0:12:33 And one in Vietnam had no travel history, but was in contact with the confirmed case.
    0:12:35 His father had a travel history to Wuhan.
    0:12:39 So what we do know is that human to human transmission is occurring. The preliminary
    0:12:42 are not estimate that was presented at the International Health Regulations Emergency
    0:12:49 Committee was a range of 1.4 to 2.5, which relatively to the measles example is not as
    0:12:54 crazy bad. SARS had an R not between two to five. So that kind of puts that those numbers
    0:12:55 in perspective.
    0:12:59 It might be a little premature to set these numbers just because the number of cases is
    0:13:04 still been relatively low and they haven’t had time to play themselves out. So we don’t
    0:13:08 know if there’s many, many cases out there who have not presented symptoms and therefore
    0:13:12 we don’t have clear stats on those people.
    0:13:17 The big question here is how bad is this epidemic? That’s the question with every epidemic. And
    0:13:20 it’s actually so much more complicated than that because there’s a number of different
    0:13:24 variables that go into determining how bad something is going to be. It’s very tempting
    0:13:29 to put sort of a single number on how bad on a scale of one to 10, for example, but it
    0:13:33 doesn’t really take into account all of the nuance in each particular epidemic.
    0:13:38 So our not is calculated from the data is actually an aggregate measure. There’s a lot
    0:13:41 of different variables that go into our not. So to break them all down into their individual
    0:13:44 components and then we can build them back up into our not.
    0:13:48 There’s a lot of variables that are going to matter here. One is how well does the virus
    0:13:53 transmit itself? So if it’s airborne, it’s able to multiply or transmit itself substantially
    0:13:54 more easily.
    0:13:59 Right. Versus like exchanging bodily fluids and which requires a lot of specific contact.
    0:14:03 Exactly. Another piece is how is it actually getting into the cells? Is it good at infecting
    0:14:09 cells? Is it good at its job essentially? Another question is what is the population that it’s
    0:14:15 occurring inside of? Is that population moving a lot? Are people coming into very close contact
    0:14:20 with each other? So that’s also going to factor in particularly interesting feature of this
    0:14:24 is that it happened during Chinese New Year, which is a period of time when a lot of people
    0:14:26 in China travel.
    0:14:29 So what I think is really interesting to this and having worked at the Gates Foundation and
    0:14:35 seen how we think about epidemics on a global scale is that there’s different, there’s two
    0:14:39 orthogonal ways to think about an epidemic, which is how much does it spread and then
    0:14:41 how bad is it once you get it.
    0:14:44 And you’re saying it’s orthogonal or contradictory or why?
    0:14:49 So there’s a notion of case fatality, which is for each infection with what likelihood
    0:14:53 will the person die from that infection or have like very serious complications. And that’s
    0:14:57 actually completely orthogonal to all of the other variables that we talked about before.
    0:15:03 One is that if the virus is actually not that deadly or if it expresses itself in a person
    0:15:07 after a substantial incubation sign, it might end up creating a bigger epidemic because
    0:15:13 that additional time will allow the patient to infect additional individuals. The are
    0:15:19 not for that particular virus might be substantially higher, even though its fatality rate is lower.
    0:15:23 So it’s an interesting paradox that you could actually have a virus that is less bad once
    0:15:26 you get it, but is more bad on the population scale.
    0:15:30 So you have to define the metric by which you’re saying whether or not an epidemic is
    0:15:34 bad. Is it the number of people who die? Is it the number of people who are infected?
    0:15:38 Is it the extent of the spread geographically? There’s a lot of different ways to think about
    0:15:40 how bad an epidemic is.
    0:15:44 Now let’s just talk about treatments and concrete things that are happening right now.
    0:15:48 So just to quickly summarize what’s happening. The CDC is conducting entry skinnings at five
    0:15:55 major airports Atlanta, Chicago, Los Angeles, LAX, New York City, JFK and San Francisco.
    0:15:58 Doctors are treating symptoms. There’s no vaccine yet. The CDC has developed a real-time
    0:16:06 reverse transcription polymerase chain reaction or RRT-PCR test that can diagnose this virus
    0:16:08 in respiratory and serum samples.
    0:16:15 So what that is is basically a way of seeing if the nucleic acids, if the patient sample
    0:16:19 contains the same sequence as the sequence that we know to be involved with the virus
    0:16:23 that we know as a part of the virus. So you don’t have to sequence every single patient.
    0:16:28 Okay, and then on January 24th, just a few days ago, the CDC publicly posted the assay
    0:16:32 protocol for this test and the quote they said, “Currently testing for this virus must
    0:16:36 take place at the CDC, but in the coming days and weeks, they will share these tests with
    0:16:40 domestic and international partners. And they’re also growing the virus and cell culture, which
    0:16:44 is necessary for further studies, including for additional characterization.”
    0:16:49 So concretely now from a practical technology point of view, because obviously this is the
    0:16:53 serious crisis. There’s a lot to be done and a lot of different players. Where do you sort
    0:16:56 of seeing some of the things that might happen that where tech can help?
    0:17:01 What’s really interesting about this moment is that because we have this increase in genomic
    0:17:08 medicine, just this past weekend, the Coalition for Epidemic Preparedness Innovations, CEPI,
    0:17:13 gave out grants to three different pharmaceutical companies of a total of $12.5 million, and
    0:17:17 they’re currently engaged in a race. These companies are targeting dates for releasing
    0:17:22 their vaccine of between four to 16 weeks from now, which is just totally unheard of.
    0:17:27 For a company to spin up a vaccine for the SARS epidemic in 2003 would have taken months
    0:17:32 to years for them to develop the new drug and actually get it approved. In this case,
    0:17:36 two of these companies made these types of vaccines for other sequences. They’re able
    0:17:40 to take what they’ve already built in-house for their other programs, and they can just
    0:17:44 very quickly adapt it to this particular virus. All they have to do is create a drop-in replacement
    0:17:49 of the sequence that they’ve already worked on with the sequence of this new coronavirus.
    0:17:55 Is it fair to say that it’s not dissimilar to engineering in terms of semiconductor and
    0:17:58 manufacturing lines? When you say drop-in sequence, does that mean that it’s basically
    0:18:03 a matter of using existing scaling methods and you’re just changing the actual code,
    0:18:04 quite literally the biological code?
    0:18:09 I think that’s actually a really good way of describing it. It’s changing the code,
    0:18:12 but you already have the manufacturing line set up. You already know exactly how you’re
    0:18:17 going to make this thing. There may be differences, but they will be minimal compared to the differences
    0:18:20 that would have existed with a completely different medicine.
    0:18:22 Having to bespoke or custom-make it yourself.
    0:18:23 Yeah, exactly.
    0:18:28 Bottom-line it for me, Judy. How should we think about this news about the coronavirus
    0:18:35 still developing? Just to be very clear. Specifically, this is for NCOV 2019. We’ve
    0:18:39 covered the high level of what we know and what we don’t know. What would your bottom-line
    0:18:42 be from the perspective of a bioengineer?
    0:18:46 The bottom-line is that we really need to think about how we are interacting with people,
    0:18:51 how we’re traveling, and how we are protecting ourselves from the virus. From my perspective
    0:18:57 as a bioengineer, we’ve been talking about how sequencing and synthesis of DNA is becoming
    0:19:02 faster and cheaper every single day. This is an example of that in action. This is not
    0:19:06 something that would have been possible even a couple of years ago. I think that what we’re
    0:19:10 seeing is the beginning of how quickly and how efficiently we’re going to be able to
    0:19:16 get to vaccines in the future as we continue to decrease the cost of sequencing and synthesis.
    0:19:20 This is a really interesting time because we’re able to figure out the diagnostics piece,
    0:19:25 the vaccine piece, and the treatment piece. It’s still in progress, but we have a huge
    0:19:26 head start.
    0:19:33 Thank you, Judy. For those of you who would like more information, please visit www.cdc.gov/coronavirus.
    0:19:38 I’ve also included the link sources for this episode in the show notes, which you can find
    0:19:44 at a6nc.com/16minutes. As a reminder, if you haven’t already subscribed to this separate
    0:19:48 show in your podcast feed, please do so now and thank you for listening.

    This episode of 16 Minutes on the news from a16z is all about the recent coronavirus outbreak — or rather, a new type of coronavirus called 2019-nCoV for 2019 novel coronavirus. Since it’s an ongoing and fast-developing news cycle, we take a quick snapshot for where we are, what we know, and what we don’t know, and discuss the vantage point of where tech comes in. Topics covered include:

    • definition of a virus, categories of coronaviruses
    • origins and spread
    • how this stacks up so far against SARS and MERS
    • speed of sequencing, implications of genomic info
    • speed of information sharing
    • R0 (“r-naught”/”nought”) and what it measures
    • different ways to think about how bad a given epidemic is
    • current moves and treatments

    Our a16z guest is Judy Savitskaya on the bio team, in conversation with Sonal Chokshi.

    Link sources or background readings for this episode:

    Other background readings / pieces mentioned in this episode: 

    • “Scientists are moving at record speed to create new coronavirus vaccines–but they may come too late”, Jon Cohen, Science (AAAS), January 27
    • “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”, The Lancet, January 24
    • “Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin”, bioRxiv, January 2 *note – preprint, NOT peer reviewed*
    • “The deceptively simple number sparking coronavirus fears”, Ed Yong, The Atlantic, January 28 *this appeared AFTER this episode was recorded, so sharing here as additional reading only*

    image: CDC