Dr. Read Montague, PhD, is a professor and director of the Center for Human Neuroscience Research at Virginia Tech and an expert in how dopamine and serotonin shape human learning, motivation and decision-making. We discuss how they impact focused effort in the context of short- and long-term goals of all kinds. Also, how SSRIs and low-effort, high-engagement activities reduce the rewarding properties of dopamine, and how AI algorithms are revolutionizing understanding of the brain.
Episode show notes are available at hubermanlab.com.
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Timestamps
(00:00:00) Read Montague
(00:02:54) Dopamine, Motivation & Learning
(00:08:49) Reward Prediction Error, Expectations
(00:12:24) Sponsors: David & Joovv
(00:14:54) Foraging, Dating, Expectations vs Outcomes; AI
(00:23:36) Dopamine, Expectation, Motivation; Forward Drive; Dopamine “Hits”
(00:29:58) Baseline Dopamine & Fluctuations; Parkinson’s Disease
(00:34:36) Movement, Urgency; ADHD, Bee’s Dance, Explorer vs Focus Mode
(00:42:29) Sponsor: AG1
(00:43:40) Social Media, ADHD; Explorers vs Task-Based, Combat
(00:50:54) Effort, Learning; Social Media & Phones, Resisting Behaviors
(01:01:36) Serotonin & Dopamine, Opponency, SSRIs
(01:11:21) Hunger, Dopamine; Negative Feedback, Learning, Trauma; Torture
(01:18:34) Drugs of Abuse & High Dopamine
(01:19:48) Sponsor: Function
(01:21:35) Trauma & Dopamine Adaptation
(01:27:34) SSRIs, Dopamine, Positive Experiences
(01:29:50) Deep Brain Stimulation; Measuring Dopamine & Serotonin in Humans
(01:36:16) Sleep; Divorce; Science is a Contact Sport
(01:45:14) Long-Term Motivation, Learning How to Fail, Tool: Kids & Sports
(01:54:14) Sponsor: LMNT
(01:55:34) Meditation, Breathing, Learning; Dopamine as a Currency
(02:04:38) Function of Sleep, Motivation; Time Perception & Dopamine, Tracking Time
(02:13:18) LLMs, AI, Uses & Problem Solving
(02:18:33) Future Projects, Commercial Brain-Machine Interfaces; Concentration
(02:25:57) Dopamine “Hits”?; Depression & Schizophrenia; Quitting
(02:30:17) Dopamine & Serotonin Misunderstandings; Internal Satisfaction; Motivation
(02:35:58) Serotonin Syndrome; Acknowledgements
(02:38:31) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
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