a16z Podcast

  • RIP to RPA: How AI Makes Operations Work

    Intelligent automation is transforming industries by tackling messy, unstructured workflows that traditional Robotic Process Automation (RPA) couldn’t handle. In this episode, a16z partner Kimberly Tan discusses the shift from rigid RPA systems to AI-powered agents…


  • Marc Andreessen: Can Tech Finally Fix Healthcare?

    Healthcare is a $4 trillion industry, making up nearly a fifth of the U.S. economy—but despite having some of the best doctors and advanced technology, the system often delivers poor outcomes at skyrocketing costs. Why…


  • Building Substack: Reinventing Media Through the Inbox

    Email, a technology from 1971, is powering one of today’s most disruptive media platforms. In this episode, Substack cofounder and CEO Chris Best joins a16z General Partner Andrew Chen to discuss the origins and evolution…


  • Crypto Trends for 2025: Stablecoins, App Stores, UX, and More

    with @sambroner @meigga @darenmatsuoka @jneu_net @chrislyons and @rhhackett @smc90 Welcome to our special end-of-year episodes — which also look ahead to 2025 —  covering our annual Big Ideas lists, where various a16z crypto team members…


  • Super Staffing Healthcare, Codifying Compliance, & Scaling Services

    As we prepare to step into 2025, the possibilities for applied AI are reshaping industries in profound ways.  In this episode, a16z General Partners Julie Yoo and Angela Strange, and Partner Joe Schmidt, dive into…


  • The Race for AI—Search, National Infrastructure, & On-Device AI

    The AI race is on, and 2025 could be its most transformative year yet. In this episode, a16z General Partners Anjney Midha and Jennifer Li, and Partner Alex Immerman dive into the trends reshaping AI…


  • Jobs of the Future, Harnessing Earth Observation, & Gaming Tech Advances

    As 2025 begins, industries are evolving at unprecedented speed: robots are revolutionizing manufacturing, terabytes of earth observation data are driving new possibilities, and gaming technology is transforming how we design, train, and innovate across sectors.…


  • Scaling Shopify: Tobias Lütke and Ben Horowitz on Building a Global Giant

    In this episode of Web3 with a16z, Shopify CEO and cofounder Tobias Lütke joins a16z cofounder Ben Horowitz for a conversation recorded live at the a16z crypto Founders Summit. Together, they explore what it takes…


  • How AI is Transforming Labor Markets

    Did you know the U.S. nurse labor market is over $600 billion annually, but the dedicated software market for nurses is almost zero? In this episode General Partners Alex Rampell, David Haber, and Angela Strange…


  • Fixing Education in America: What’s Stopping Us?

    Over half of Americans live in childcare deserts, while 90% of brain development happens before the age of five. All the while, education and childcare remain among the most resistant sectors to technological change. Billions…