a16z Podcast
AI is becoming the orchestration layer inside the enterprise.
In this episode of Big Ideas 2026, we explore the shift from isolated AI copilots to coordinated multi-agent systems that plan, analyze, and execute work across teams and tools. This is not a new feature, but a new way workflows run inside large organizations.
You will hear from Seema Amble on context extraction and coordinated agent teams, Angela Strange on why unified data and parallel workflows accelerate core replacement, Alex Immerman on multiplayer AI and execution boundaries, and David Haber on what makes these systems commercially defensible.
Together, these perspectives define the enterprise orchestration layer: not a chatbot and not a standalone tool, but a coordinated system of agents that runs the workflow and delivers real outcomes across the business.
Resources:
Follow Angela Strange on X: https://x.com/astrange
Follow David Haber on X: https://x.com/dhaber
Follow Alex Immerman on X: https://x.com/aleximm
Follow Seema Amble on X: https://x.com/seema_amble
Read more all of our 2026 Big Ideas
Part 1: https://a16z.com/newsletter/big-ideas-2026-part-1
Part 2: https://a16z.com/newsletter/big-ideas-2026-part-2/
Part 3: https://a16z.com/newsletter/big-ideas-2026-part-3/
Stay Updated:
If you enjoyed this episode, be sure to like, subscribe, and share with your friends!
Find a16z on X: https://twitter.com/a16z
Find a16z on LinkedIn: https://www.linkedin.com/company/a16z
Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX
Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711
Follow our host: https://x.com/eriktorenberg
Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
Stay Updated:
Find a16z on X
Find a16z on LinkedIn
Listen to the a16z Show on Spotify
Listen to the a16z Show on Apple Podcasts
Follow our host: https://twitter.com/eriktorenberg
Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

-
Big Ideas 2026: The Enterprise Orchestration Layer
AI is becoming the orchestration layer inside the enterprise. In this episode of Big Ideas 2026, we explore the shift from isolated AI copilots to coordinated multi-agent systems that plan, analyze, and execute work across…
-
Big Ideas 2026: The Agentic Interface
AI is moving from chat to action. In this episode of Big Ideas 2026, we unpack three shifts shaping what comes next for AI products. The change is not just smarter models, but software itself…
-
The Rise, Fall & Reset of The Fintech Industry
Fintech went from a full-blown surge to a near standstill in just two years. At its peak, about 25 percent of all venture dollars were pouring into the category. By late 2022, that number had…
-
Do Revenue and Margins Still Matter in AI?
In this episode, we’re sharing a conversation with David George, General Partner at a16z on the firm’s growth investing team. David has been involved in backing many of the defining companies of this era and…
-
The Crime Crisis In America and How Technology Fixes It
What if America tried to eliminate crime instead of just reacting to it? Not with slogans, but with staffing, technology, and strategy scaled to the problem. In this episode, Erik Torenberg speaks with Garrett Langley,…
-
Ryo Lu (Cursor): AI Turns Designers to Developers
Ryo Lu spent years watching his designs die in meetings. Then he discovered the tool that lets designers ship code at the speed of thought: Cursor, the company where Ryo is now Head of Design.…
-
Dwarkesh and Ilya Sutskever on What Comes After Scaling
AI models feel smarter than their real-world impact. They ace benchmarks, yet still struggle with reliability, strange bugs, and shallow generalization. Why is there such a gap between what they can do on paper and…
-
AI Eats the World: Benedict Evans on the Next Platform Shift
AI is reshaping the tech landscape, but a big question remains: is this just another platform shift, or something closer to electricity or computing in scale and impact? Some industries may be transformed. Others may…
-
The Inside Story of Growth Investing at a16z
This episode is a special replay of David George’s conversation with Harry Stebbings on 20VC. David is a General Partner on a16z’s growth team, and in this discussion he breaks down how he thinks about…
-
How the Best CEOs Delegate
Jonathan Swanson has built two rare successes: Thumbtack, the home-services marketplace, and Athena, the fast-growing platform that pairs ambitious people with world-class personal assistants. Today he runs a 4,000-person company, invests on the side, and…
