a16z Podcast
What happens when AI collides with salesmanship, streaming-era sports, and healthcare?
In this episode, Erik Torenberg is joined by Mark Cuban, entrepreneur, Dallas Mavericks co-owner, and founder of Cost Plus Drugs.
Topics include fiery group chats and how dissent sharpens thinking, the sales playbook of modern politics, and concrete fixes for U.S. healthcare like ending PBM opacity, publishing real prices, and government-backed patient financing. Mark also explains how AI is pushing media from “social” to algorithmic, why he expects millions of models, and why ESOPs are an underrated wealth engine. He shares what he’d build today and weighs in on NBA economics under the new collective bargaining agreement.
Timecodes:
00:00 Introduction
00:47 Salesmanship, Politics, and Social Media
04:05 AI, Algorithms, and the Future of Media
06:29 Fragmentation of Social Platforms
09:04 Political Messaging & Economic Populism
12:05 Wealth, Equity, and Employee Ownership
16:39 AI’s Impact on Education and Healthcare
21:32 Fixing the US Healthcare System
29:39 Entrepreneurship in the Age of AI
33:38 Business Success, Sports, and Investments
35:32 NBA Economics and Team Building
50:44 Personal Priorities & Closing Thoughts
Resources:
Find Mark on X: https://x.com/mcuban
Stay Updated:
Let us know what you think: https://ratethispodcast.com/a16z
Find a16z on Twitter: https://twitter.com/a16z
Find a16z on LinkedIn: https://www.linkedin.com/company/a16z
Subscribe on your favorite podcast app: https://a16z.simplecast.com/
Follow our host: https://x.com/eriktorenberg
Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

-
The Techno-Optimist Manifesto with Marc Andreessen and Ben Horowitz
Subscribe to The Ben & Marc Show on Apple Podcasts: https://bit.ly/3SdsfNt Subscribe to The Ben & Marc Show on Spotify: https://spoti.fi/3SclPOr Read the full manifesto: https://a16z.com/the-techno-optimist-manifesto/ This past week, Marc released his new vision…
-
A New Era of VR: From the Court to the Classroom
As VR technology inches forward, completely new experiences loom on the horizon. In today’s episode, we expose listeners to the very real-world use cases already present on these devices, from fitness to education. First up…
-
When Will AI Hit the Enterprise? Ben Horowitz and Ali Ghodsi Discuss
Today’s episode continues our coverage from a16z’s recent AI Revolution event. You’ll hear directly from a16z cofounder Ben Horowitz and Databricks cofounder and CEO, Ali Ghodsi as they answer questions around AI and the enterprise,…
-
When AI and Genomics Collide
Today’s episode continues our coverage from a16z’s recent AI Revolution event. You’ll hear a16z Bio & Health GP Vijay Pande speak with Daphne Koller about the fascinating convergence of machine learning and genomics – two…
-
AI Revolution: Disruption, Alignment, and Opportunity
The AI Revolution is here. In this episode, you’ll learn what the most important themes that some of the world’s most prominent AI builders – from OpenAI, Anthropic, CharacterAI, Roblox, and more – are paying…
-
AI Revolution: Top Lessons from OpenAI, Anthropic, CharacterAI, & More
The AI Revolution is here. In this episode, you’ll learn what the most important themes that some of the world’s most prominent AI builders – from OpenAI, Anthropic, CharacterAI, Roblox, and more – are paying…
-
Engineering Rapidly Reusable Rockets
The space industry is evolving rapidly, with the cost of launching payloads to orbit dropping significantly. But who’s investing in this sector, and how will it evolve? In this episode, we delve into the transformative…
-
The Evolution of the Satellite Economy
The cost of launching payloads to orbit has dramatically dropped, igniting a space renaissance. In 2022, a record 186 rocket launches (41 more than the previous year!) underscores this shift. In Part 1 of our…
-
AI x Crypto
with @alive_eth @danboneh @smc90 This week’s all-new episode covers the convergence of two important, very top-of-mind trends: AI (artificial intelligence) & blockchains/ crypto. These domains together have major implications for how we all live our…
-
Salary Transparency: Clarity or Chaos?
With recent landmark legislation being passed around salary transparency, many companies are playing catch up as they interpret and implement changes. In this episode, members of the a16z People Operations team, Shannon Schiltz and Brandon…