a16z Podcast

  • The Shift in Global Drug Development

    Theo Jaffee and Gabriel Dickinson speak with Cremieux about China’s rapid rise to the top of global clinical trial output. They discuss the regulatory reforms that accelerated China’s progress, the surge in novel drug development,…


  • John and Patrick Collison on Stripe’s Growth, Agent Commerce, and the Future of Software

    This interview with Stripe cofounders John and Patrick Collison originally aired on TBPN. They discuss Stripe’s 34% growth and new employee tender offer, how agent commerce and stablecoins may require high-throughput blockchains built for millions…


  • Ben Horowitz on Venture Capital and AI

    Anjney Midha, founder of AMP PBC, speaks with Ben Horowitz, cofounder of a16z, about how venture capital changed from a small, relationship-driven business into a scalable system for backing new technology companies. They discuss network…


  • AI Inside the Enterprise

    Steven Sinofsky, board partner at a16z, Aaron Levie, CEO of Box, and Martin Casado, general partner at a16z, discuss the reality of AI inside enterprises. They cover the gap between Silicon Valley and the rest…


  • Martin Shkreli on AI, Pharma, and What Actually Matters

    Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk through the future of…


  • Balaji Srinivasan: Prove Correct, Not Just Go Direct

    Erik Torenberg and Theo Jaffee speak with Balaji Srinivasan, angel investor, entrepreneur, and author of The Network State, about how AI is transforming media, eroding trust, and reshaping how information is created and verified. They…


  • Marc Andreessen: Monitoring the Situation and the Future of Media

    Erik Torenberg and Theo Jaffee speak with Marc Andreessen, cofounder and general partner at a16z, about the launch of Monitoring the Situation (MTS), a new, always-on media network on X. They discuss the rise of…


  • Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon

    Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler, about why Git’s user interface has barely changed since 2005, how GitButler is rethinking version control for both humans and AI agents,…


  • Network Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose Show

    This episode originally aired on The Kevin Rose Show. Kevin Rose speaks with Anish Acharya, general partner at a16z, about how AI is rewriting the rules of consumer software, the defensibility of network effects in…


  • From Models to Mobility: Building Waymo with Dmitri Dolgov

    Waymo is now delivering hundreds of thousands of fully autonomous rides each week — but getting there required more than better models. It meant building a complete system for training, evaluating, and deploying a driver…


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