a16z Podcast

  • Marc Andreessen on Why This Is the Most Important Moment in Tech History

    Recently, Marc Andreessen joined Lenny Rachitsky on Lenny’s Podcast. They talked about why 2025 may be the most significant year in tech history, how AI is reshaping the future of product managers, designers, and engineers,…

  • Ben Horowitz and Balaji Srinivasan on Netscape and Network States

    Can a country be built from the internet up? Not as a metaphor or an online community, but as a system that replaces institutions we usually think of as fixed, money, law, and governance. In…

  • Healthcare 2026: AI Doctors, GLP-1s, and Insurance Defection

    Out-of-Pocket is a healthcare education company founded by Nikhil Krishnan that helps people understand how healthcare works and how to navigate it in practice. In this episode, a16z Health and Bio partner Jay Rughani and…

  • The Hidden Economics Powering AI

    In this episode, Jen Kha, Head of Investor Relations, and David George, General Partner, discuss how late-stage private markets are evolving as AI reshapes scale, capital intensity, and growth timelines. They explain why AI-driven companies…

  • How Mintlify Is Rebuilding Documentation for Coding Agents

    Mintlify is a documentation platform built by cofounders Han Wang and Hahnbee Lee to help teams create and maintain developer docs. In this episode, Andreessen Horowitz general partners Jennifer Li and Yoko Li speak with…

  • Inferact: Building the Infrastructure That Runs Modern AI

    Inferact is a new AI infrastructure company founded by the creators and core maintainers of vLLM. Its mission is to build a universal, open-source inference layer that makes large AI models faster, cheaper, and more…

  • Martin Casado on the Demand Forces Behind AI

    In this feed drop from The Six Five Pod, a16z General Partner Martin Casado discusses how AI is changing infrastructure, software, and enterprise purchasing. He explains why current constraints are driven less by technical limits…

  • From Code Search to AI Agents: Inside Sourcegraph’s Transformation with CTO Beyang Liu

    Sourcegraph’s CTO just revealed why 90% of his code now comes from agents—and why the Chinese models powering America’s AI future should terrify Washington. While Silicon Valley obsesses over AGI apocalypse scenarios, Beyang Liu’s team…

  • The AI Opportunity That Goes Beyond Models

    The a16z AI Apps team outlines how they are thinking about the AI application cycle and why they believe it represents the largest and fastest product shift in software to date. The conversation places AI…

  • How Foundation Models Evolved: A PhD Journey Through AI’s Breakthrough Era

    The Stanford PhD who built DSPy thought he was just creating better prompts—until he realized he’d accidentally invented a new paradigm that makes LLMs actually programmable. While everyone obsesses over whether LLMs will get us…

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