a16z Podcast

  • The State of AI: Macro, Apps, and Consumer

    Anish Acharya joins Jen Kha to break down the next frontier of AI, from the evolving model landscape and open-source AI to why the application layer, and consumer AI in particular, may be entering a…


  • The New Economics of AI | Martin Casado & Steven Sinofsky

    a16z General Partners Martin Casado and Erik Torenberg are joined by Board Partner Steven Sinofsky to explore what recent breakthroughs in AI and mathematics tell us about where the technology is headed, and whether some…


  • Why Medical AI Needs a Referee | Protege’s Engy Ziedan

    Daisy Wolf and Eva Steinman are joined by Engy Ziedan, co-founder and Chief Scientific Officer of Protege, to discuss why medical AI has a measurement problem, and why scoring well on a benchmark doesn’t necessarily…


  • Martin Casado on Where the Value Is Going in AI

    Martin Casado joins MTS hosts Theo Jaffee and Sophia Dew to unpack where value is actually accruing in AI, why this technology cycle looks fundamentally different from previous waves, and whether the frontier labs will…


  • How Microsoft Is Securing the Agentic Enterprise | Aaron Zollman

    a16z’s Joel De La Garza is joined by Aaron Zollman, Deputy CISO at Microsoft Gaming, to discuss how security teams can embrace AI agents without losing control. Aaron shares Microsoft’s experience with OpenClaw, from the…


  • How Global Networks Are Reshaping Startup Success

    Elena Burger is joined by a16z’s Angela Strange and Gabriel Vasquez to discuss the rise of the “borderless founder”: entrepreneurs who bring the networks and insights of their home markets together with the talent, capital,…


  • How Whatnot Built a Global Marketplace

    a16z General Partner David George is joined by Grant LaFontaine, co-founder of Whatnot, to unpack how a marketplace that started with collectibles evolved into one of the world’s leading live shopping platforms. Grant traces the…


  • How Do You Defend Against AI That Can Hack?

    a16z’s Joel De La Garza is joined by Nick Warner of Neo and Max Pollard of Cotool to discuss what happens when cybersecurity tools built to defend against humans and malware suddenly have to contend…


  • Stripe’s AI Strategy: Build More, Not Less

    a16z General Partner David George is joined by Will Gaybrick, President of Product & Business at Stripe, to discuss how AI is changing the way Stripe builds products, organizes teams, and thinks about the future…


  • Ben Horowitz and Travis Kalanick on Building Again

    Ben Horowitz, Travis Kalanick, and Erik Torenberg take the stage at Atoms’ launch event for a candid fireside conversation about entrepreneurship, company building, and why Kalanick believes the next industrial revolution will be powered by…


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