a16z Podcast

  • Can Open Source Keep AI Power From Concentrating?

    MTS host Sophia Dew visits the Open Source AI Summit in San Francisco to ask researchers and founders across the AI stack a central question: can open source prevent AI power from concentrating in the…


  • Your AI Doctor Is Coming | Julie Yoo

    a16z General Partner Julie Yoo joins MTS host Sophia Dew to explain why she believes healthcare could benefit more from AI than almost any other industry, and why decades of slow technology adoption may actually…


  • Aaron Levie on Why Open AI Wins

    Box co-founder and CEO Aaron Levie joins MTS hosts Theo Jaffee and Sofia Puccini to make the case for open-weight AI, unpack the economics of open versus closed models, and explain why he believes more…


  • Fei Fei Li: The Race to Build World Models For AI

    World Labs co-founders Fei-Fei Li, Justin Johnson, and Ben Mildenhall join a16z General Partner Martin Casado to discuss Atlas, their latest world model, and what it reveals about the pursuit of spatial intelligence. At the…


  • The $100B Niches Hiding Inside Payments

    Erik Torenberg is joined by a16z General Partner Alex Rampell and Affirm Co-Founder and CEO Max Levchin for a conversation on 25 years of fintech, from the early days of digital payments to the origins…


  • Inside Moderna’s Personalized Cancer Vaccine

    a16z General Partner Jorge Conde sits down with Moderna CEO Stéphane Bancel to discuss a major milestone for mRNA technology: positive Phase 3 results from Moderna and Merck’s individualized treatment for melanoma, after more than…


  • Daniel Litt: The Mathematician’s Guide to AI

    a16z’s Lisha Li sits down with Daniel Litt, Assistant Professor of Mathematics at the University of Toronto, to unpack AI’s rapid progress in mathematics, what today’s frontier models can actually do, and what they’re still…


  • Gavin Baker: Why AI Demand Is Outrunning Compute Supply

    a16z’s David George sits down with Gavin Baker to unpack the state of the AI boom, why demand for intelligence may still be dramatically underestimated, and why the outcome doesn’t necessarily have to be winner-take-all.…


  • Why a16z Launched the Machine Age Fund | Jen Kha

    a16z Managing Partner and Head of Global Partnerships Jen Kha joins MTS hosts Theo Jaffee and Sophia Dew to discuss a16z’s Machine Age Fund and the investment thesis behind rebuilding the physical infrastructure that powers…


  • Why 1,200 AI Agents Started Working Together | Ryan Greenblatt

    Ryan Greenblatt, Chief Scientist at Redwood Research, joins MTS host Theo Jaffee to unpack a new independent investigation into the OpenAI Hugging Face hacking incident and what it reveals about how large groups of AI…


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