a16z Podcast

  • The Engine Powering Open-Source AI

    Elena Burger and Matt Bornstein are joined by Simon Mo, co-founder and CEO of Inferact, the open-source inference engine powering many of today’s most advanced AI applications. Together, they explore how open-source AI evolved from…


  • Three Startups Reinventing Critical Infrastructure

    This week, a16z American Dynamism Films premiered three short documentaries highlighting companies tackling some of America’s biggest industrial challenges: Ulysses, Mariana Materials, and Radiant. Before watching those films, we’re revisiting conversations with the founders behind…


  • OpenAI’s Joshua Achiam: Did We Already Reach AGI?

    Theo Jaffee is joined by Joshua Achiam, Chief Futurist at OpenAI, for a conversation on AI cybersecurity, frontier model capabilities, and why he believes society may have already crossed the threshold into an AGI-era without…


  • Ruby Thelot on Internet Culture, AI, and the Future of Taste

    Sophia Dew and Sofia Puccini are joined by Ruby Thelot, designer, artist, cyberethnographer, professor at NYU, and founder of 13101401, for a wide-ranging conversation about internet culture, AI, digital communities, and how technology is reshaping…


  • Marc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation

    Marc Andreessen, Chris Dixon, and Robert Hackett discuss one of the most consequential policy debates facing the crypto industry: the push for comprehensive U.S. market structure legislation and what regulatory clarity could mean for innovation,…


  • How Enterprise AI Really Gets Deployed

    Sarah Wang and Kimberly Tan are joined by Jesse Zhang and Ashwin Sreenivas, co-founders of Decagon, to discuss the evolution of enterprise AI agents, why the company increasingly relies on open-source models, and how it…


  • AI for America’s Small Businesses | Lassie

    Alex Rampell and Olivia Moore speak with Lassie cofounders Steijn Pelle and Frédéric Renken about bringing AI to one of the most overlooked parts of the economy: small businesses. Inspired by time spent working inside…


  • AI Micro Dramas, Generative Media, and the Future of Creativity

    Justine Moore, partner at Andreessen Horowitz, joins New Economies to explore the rapid evolution of generative media and why AI-native content is reaching an inflection point. They discuss the rise of AI micro-dramas, how creators…


  • Fei-Fei Li on Spatial Intelligence and Robotics

    Last week, World Labs announced its acquisition of SceniX, bringing together two teams working on one of AI’s biggest unsolved problems: how to give machines a true understanding of the physical world. Martin Casado sits…


  • Steven Sinofsky: AI Doesn’t Need New Rules Yet

    Steven Sinofsky joins Theo Jaffee and Sofia Puccini for a conversation on AI regulation, open-source models, and what history can teach us about technological revolutions. Drawing on decades of experience leading products at Microsoft, Sinofsky…


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