a16z Podcast

  • The Brutal Truth About Biotech: Why $2B Per Drug Is Killing Innovation

    Two venture capitalists dissect why biotech burns billions while China runs trials in weeks—and why the next Genentech won’t look anything like the last one. Elliot Hershberg reveals the “three horsemen” strangling drug development as…


  • The Frontier of Spatial Intelligence with Fei-Fei Li

    Fei-Fei Li and Justin Johnson are pioneers in AI. While the world has only recently witnessed a surge in consumer AI, they have long been laying the groundwork for the innovations transforming industries today. With…


  • Rocket Mortgage CEO: Here’s How to Fix the Housing Crisis

    The Empire State Building took 110 days to build—today, changing a window would take two years.  Alex Rampell (a16z) and Varun Krishna (Rocket CEO) expose how asset inflation turned housing from the American Dream into…


  • Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

    Grant Lee was told Gamma was “the worst idea ever heard” by an investor who hung up mid-Zoom—yet he built it to 100 million users and $100M ARR without spending a dollar on advertising. While…


  • Michael Truell: How Cursor Builds at the Speed of AI

    When four MIT grads decided to build a code editor while everyone else was building AI agents, they created the fastest-growing developer tool ever built.  Cursor CEO Michael Truell joins a16z’s Martin Casado to discuss…


  • a16z’s State of Crypto: The $4 Trillion Milestone and What’s Next’

    The regulatory environment has completely inverted. Stablecoins are now a top 20 holder of US treasuries. Every major bank wants in. In a16z Crypto’s 2025 State of Crypto report, Daren Matsuoka (Head of Data) and…


  • Amjad Masad & Adam D’Angelo: How Far Are We From AGI?

    Adam D’Angelo (Quora/Poe) thinks we’re 5 years from automating remote work. Amjad Masad (Replit) thinks we’re brute-forcing intelligence without understanding it. In this conversation, two technical founders who are building the AI future disagree on…


  • Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

    Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of…


  • Seeing The Future from AI Companions to Personal Software

    Eugenia Kuyda, CEO of Wabi and AI pioneer behind Replika, joins Erik, Anish, and Justine to reveal how personal software will transform from a developer monopoly to a creative medium for all. She exposes why…


  • ElevenLabs CEO: Why Voice is the Next AI Interface

    ElevenLabs CEO and co‑founder Mati Staniszewski joins Jennifer Li to explain how the team ships research‑grade AI at lightning speed—from text‑to‑speech and fully licensed AI music to real‑time voice agents—and why voice is the next…


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