Huberman Lab
My guest is Dr. David Fajgenbaum, MD, professor of translational medicine and human genetics at the University of Pennsylvania. He explains how, unbeknownst to most doctors, many approved medications can successfully treat or even cure diseases other than the ones they are typically used to treat. He shares his story of escaping death from Castleman’s disease by discovering a life-saving treatment using repurposed drugs that were approved for other purposes. Our conversation explores how researchers, physicians, and you—the general public—can explore novel treatments and cures to conditions the medical profession has deemed untreatable, including cancers. We also discuss the crucial role of mindset in battling diseases and the lesser-known use of compounds to promote health and longevity.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AGZ by AG1: https://drinkagz.com/huberman
Eight Sleep: https://eightsleep.com/huberman
Rorra: https://rorra.com/huberman
David: https://davidprotein.com/huberman
Function: https://functionhealth.com/huberman
Timestamps
(0:00) David Fajgenbaum
(4:06) Self-Agency in Healthcare; New Uses for Old Medicines
(6:44) Other Uses of Aspirin & Viagra; Drug Development & Approved Use
(8:53) Lidocaine & Breast Cancer; Pharmaceutical Companies & Incentives
(11:36) Sponsors: Eight Sleep & Rorra
(14:16) Pharmaceutical Companies, Patents & New Uses; Lithium
(18:40) Tools: Finding Reliable Health Sources, Asking Questions & Disease Organizations; DADA2 Treatment
(21:53) Medical Community & Connections; Integrated Medical Databases
(24:36) Drug Repurposing, Thalidomide, Pembrolizumab
(28:45) Medical Research Databases, Mapping Disease Connections
(33:51) Every Cure Database & Programs, Bachmann-Bupp Syndrome; Colchicine & Heart Disease
(37:57) Sponsors: AGZ by AG1 & David
(40:41) David’s Medical & Career Journey, Glioblastoma, Castleman Disease
(49:10) Autoimmune Disease, Driven Personality, Stress & Immune System
(52:52) Castleman Disease, Treatment, Chemotherapy
(55:54) Physician Continuing Education, Santa Claus Theory of Civilization; Science Collaboration
(1:03:32) Medical School, Relapse & “Overtime”, Finding a New Treatment, Rapamycin
(1:12:46) Sport, Football & Resilience; Challenge & Personal Growth, Family
(1:18:41) Sponsor: Function
(1:20:29) Social Support; “Overtime”, Gratitude
(1:23:19) Business School, Castleman Disease Treatment; Repurposing Drugs & AI
(1:28:29) Drug Repurposing, POEMS Syndrome; Mitigating Risk
(1:35:32) Nicotine, Compounds for Preventive Health; GLP-1 Agonists
(1:40:51) Bioprospecting, Drug Development; AI, Prioritization & Novel Connections
(1:46:18) Healthcare & Children; Hope, Action & Impact Circuit; Challenge & Super-Agers
(1:52:50) Get Involved with Every Cure
(1:56:20) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Learn more about your ad choices. Visit megaphone.fm/adchoices
Journal Club with Dr. Peter Attia | Effects of Light & Dark on Mental Health & Treatments for Cancer
In this journal club episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins-trained physician focusing on healthspan and lifespan and the host of The Drive podcast. We each present a peer-reviewed…
Dr. Sean Mackey: Tools to Reduce & Manage Pain
In this episode, my guest is Dr. Sean Mackey, M.D., Ph.D., Chief of the Division of Pain Medicine and Professor of Anesthesiology, Perioperative and Pain Medicine and Neurology at Stanford University School of Medicine. His…
How to Prevent & Treat Colds & Flu
In this episode, I explain the biology of the common cold and flu (influenza) and how the immune system combats these infections. I describe behavior, nutrition and supplementation-based tools supported by peer-reviewed research to enhance…
David Goggins: How to Build Immense Inner Strength
In this episode, my guest is David Goggins, retired Navy SEAL, highly accomplished ultramarathoner, best-selling author, and influential public speaker. David explains how he mastered his inner dialogue to build extraordinary levels of discipline and…
AMA #14: 2023 Philanthropy, Evening Routine, Light Therapy, Health Metrics & More
Welcome to a special edition of the 14th Ask Me Anything (AMA) episode, part of Huberman Lab Premium. This episode is a recording of a live stream AMA, originally exclusive to our Annual and Lifetime…
Rick Rubin: Protocols to Access Creative Energy and Process
In this episode, my guest is Rick Rubin, world-renowned music producer of numerous award-winning artists, including Johnny Cash, Red Hot Chili Peppers, Beastie Boys, Adele, Eminem, Slayer, and many more. Rick is also the host…
Dr. Robert Lustig: How Sugar & Processed Foods Impact Your Health
In this episode, my guest is Dr. Robert Lustig, M.D., neuroendocrinologist, professor of pediatrics at the University of California, San Francisco (UCSF), and a bestselling author on nutrition and metabolic health. We address the “calories…
LIVE EVENT Q&A: Dr. Andrew Huberman at the Chicago Theatre
Recently I had the pleasure of hosting a live event in Chicago, Illinois. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question…
Dr. Karen Parker: The Causes & Treatments for Autism
In this episode, my guest is Dr. Karen Parker, Ph.D., professor of psychiatry and director of the Social Neurosciences Research Program at Stanford University School of Medicine. We discuss the biology of social connections and…
Robert Greene: A Process for Finding & Achieving Your Unique Purpose
In this episode, my guest is Robert Greene, multiple New York Times bestselling author and expert on human psychology and behavior both at the individual and group levels and in the context of relationships, careers,…