Huberman Lab
Dr. Alex Marson, MD, PhD, is a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system and cancer, and everyday choices that can increase or decrease your cancer risk, several of which are surprising but all of which are actionable. We also discuss immunotherapy, including how engineered T-cells can be used to defeat childhood and adult cancers. Dr. Marson explains CRISPR and gene editing to cure diseases, and we address the ethical questions surrounding gene editing in embryos, children and adults. This discussion is for anyone interested in avoiding cancer and/or seeking to understand the science and practical applications of immune- or gene-therapy.
Read the show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
BetterHelp: https://betterhelp.com/huberman
Helix Sleep: https://helixsleep.com/huberman
LMNT: https://drinklmnt.com/huberman
Function: https://functionhealth.com/huberman
Timestamps
(00:00:00) Alex Marson
(00:02:21) Diseases & Current Biological Landscape; AI & Computational Tools
(00:05:56) Immune System, Innate vs Adaptive Immune System
(00:10:55) Thymus, T Cell Selection; B Cells & Antibodies
(00:13:23) Sponsors: BetterHelp & Helix Sleep
(00:16:11) Immune System Health, Sleep, Diet; Genes
(00:20:56) Childhood Exposure & Allergy Prevention; Autoimmune Reactions
(00:25:27) Whole Body Immune Response, Cytokines & Fever; Antibiotics
(00:30:51) Cancer; Mutations & Cell Regulation; Smoking, BRCA Mutations, Sunlight
(00:38:27) BRAC Mutations, Mutagens, Pesticides
(00:42:33) Sponsor: AG1
(00:43:57) X-Rays & Airport Scanners, Carcinogen vs Mutagen, Charred Meat, Food Dye
(00:49:34) Immune-Based Cancer Treatment, Checkpoint Inhibitors, CAR T-Cell Therapy
(00:59:04) CRISPR, Immunotherapies
(01:02:52) Age & Cancer Risk; CAR T-Cells, Targets & Side Effects; Ketogenic Diet
(01:08:27) CRISPR Discovery & Mechanism
(01:17:06) CRISPR Precision, Risk & Benefit; CRISPR Technology Evolution
(01:20:57) Sponsor: LMNT
(01:22:17) CRISPR Cell Delivery, Clinical Trials; Treating Early Cancers & Prevention
(01:33:47) Liposomes, Engineered Viruses, Lipid Nanoparticles (LNPs), Vaccines
(01:39:57) COVID Pandemic & Trust in Science, mRNA Vaccine
(01:47:51) Sponsor: Function
(01:49:39) Drug Delivery to Cancer, Immunotoxins, T-Cell Engagers; AI Protein Targets
(01:55:45) CRISPR Embryo Modification, Ethics; Heritable Gene Editing, Diversity
(02:05:42) Deep Sequencing Embryos, Diversity; Overcoming Adversity & Resilience
(02:10:44) Upcoming Therapeutics, Autoimmunity & CAR T-Cells, CRISPR & Gene Function
(02:17:55) Banking T Cells or iPSCs?, Future of Cell Programming
(02:24:41) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Learn more about your ad choices. Visit megaphone.fm/adchoices
GUEST SERIES | Dr. Matt Walker: The Science of Dreams, Nightmares & Lucid Dreaming
This is episode 6 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley and a leading public educator on sleep…
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation
In this episode, my guest is Dr. Casey Means, M.D., a physician trained at Stanford University School of Medicine, an expert on metabolic health and the author of the book, “Good Energy.” We discuss how to…
GUEST SERIES | Dr. Matt Walker: Improve Sleep to Boost Mood & Emotional Regulation
This is episode 5 of our 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley and the host of The Matt Walker…
AMA #17: Making Time for Fitness, Top Sleep Tools & Best Learning Strategies
Welcome to a preview of the 17th Ask Me Anything (AMA) episode, part of Huberman Lab Premium. Huberman Lab Premium was launched for two main reasons. First, it was launched in order to raise support…
Protocols to Strengthen & Pain Proof Your Back
In this episode, I explain how to strengthen and build a stable, pain-free back and how to reduce or eliminate existing back pain. I explain the anatomy and physiology of the spinal cord and vertebrae,…
GUEST SERIES | Dr. Matt Walker: Using Sleep to Improve Learning, Creativity & Memory
This is episode 4 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley, and author of the best-selling book “Why…
Dr. Bonnie Halpern-Felsher: Vaping, Alcohol Use & Other Risky Youth Behaviors
In this episode, my guest is Dr. Bonnie Halpern-Felsher, PhD, FSAHM. She is a professor of pediatrics and adolescent medicine and a developmental psychologist at Stanford University School of Medicine. Dr. Halpern-Felsher is a world…
LIVE EVENT Q&A: Dr. Andrew Huberman at the Sydney Opera House
Recently I had the pleasure of hosting a live event in Sydney, Australia. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question…
GUEST SERIES | Dr. Matt Walker: How to Structure Your Sleep, Use Naps & Time Caffeine
This is episode 3 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., a professor of neuroscience and psychology at the University of California, Berkeley, and leading public educator about the role…
Dr. David Yeager: How to Master Growth Mindset to Improve Performance
In this episode, my guest is Dr. David Yeager, Ph.D., professor of psychology at the University of Texas, Austin, and the author of the forthcoming book “10 to 25.” We discuss how people of any…