a16z Podcast

  • World’s Largest Supercomputer v. Biology’s Toughest Problems

    Proteins are molecular machines that must first assemble themselves to function. But how does a protein, which is produced as a linear string of amino acids, assume the complex three-dimensional structure needed to carry out…


  • The Return of Home-based Healthcare

    The way we deliver healthcare has changed enormously over the last century, shifting from house calls by doctors to your own to institutionalized settings like hospitals and clinics. But now that trend has started to…


  • The Future of Primary Care

    Primary care was meant to be the front door to the healthcare system, but in some ways never set up for success to begin with. We need a new operating system for primary care—one with…


  • All about Section 230: What It Does and Doesn’t Say

     We cover the tricky but important topic of Section 230 of the Communications Decency Act. The 1996 law has been in the headlines a lot recently, in the context of Twitter, the president’s tweets, and…


  • What We Can’t Reveal We Can’t Heal

    Given recent events around George Floyd and far beyond, this special episode of the a16z Podcast features Shaka Senghor, a leading advocate for criminal justice reform (and bestselling author), and Terry Brown, a former police officer…


  • SaaS Go-to-Upmarket

    For a SaaS company, it’s easier to move upmarket than down, and this gives SaaS startups the advantage against incumbents. In this episode,  David Ulevitch and our newest enterprise general partner Kristina Shen look at…


  • New Fan Engagement Models for Athletes and Influencers

    Today’s episode is about a practical application of crypto — namely, the way it can “tokenize” fandom. More broadly, it’s about fan engagement, and the increasingly blurred lines between sports, culture and tech.  We talked…


  • Don’t Call it a Brain in a Dish!

    Our understanding of the human brain and its disorders has always been limited by our lack of access to living, human, developing brain tissue. For the first time, that’s changing. In this episode, Sergiu Pasca,…


  • Pandemics: Early Detection, Networks, Spreaders

    Pandemics are predictable; what’s not predictable is the intensity, or the precise timing of arrival. That’s where early detection — not just rapid warning (as with something like Google Flu Trends back in the day),…


  • Podcasting and the Future of Audio

    This podcast (first recorded in 2019, now being rerun) — is a podcast about podcasting: But it’s really all about audio. A lot’s changed… and a lot hasn’t.  How do we define “podcasts”; how does…