a16z Podcast
As frontier AI labs expand into applications, where should startups build? a16z Partner Joe Schmidt joins HubSpot co-founder and CTO Dharmesh Shah to explore why the software opportunity is growing, and how founders can stay off the “Yellow Brick Road” the labs are racing down.
Drawing on HubSpot’s evolution, Dharmesh explains why founders should start with a narrow market, learn quickly, and solve the whole customer problem. They discuss where application companies can build lasting value as models become infrastructure: workflows, customer context, and the systems where work happens.
They also explore HubSpot’s AI experiments, the rise of one-person businesses, and why cheaper software creation could unlock markets that previously couldn’t support a software company.
Resources:
Follow Dharmesh Shah on X:https://x.com/dharmesh
Follow Joe Schmidt on X:https://x.com/joeschmidtiv
Read Joe’s essay, “Avoiding Death on the Yellow Brick Road”:
https://a16z.com/avoiding-death-on-the-yellow-brick-road/
Stay Updated:
Find a16z on YouTube: YouTube
Find a16z on X
Find a16z on LinkedIn
Listen to the a16z Show on Spotify
Listen to the a16z Show on Apple Podcasts
Follow our host: https://twitter.com/eriktorenberg
Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

-
America’s Energy Problem: The Grid That Built America Can’t Power Its Future
U.S. per capita energy usage peaked in 1973. Since then? Flat. Meanwhile, China’s per capita energy use has grown 9x. Today, AI, EVs, manufacturing, and data centers are driving demand for more electricity than ever—and…
-
Aaron Levie on AI’s Enterprise Adoption
In this episode, a16z General Partner Martin Casado sits down with Box cofounder and CEO Aaron Levie to talk about how AI is changing not just software, but the structure and speed of work itself.…
-
Ben Horowitz: What Founders Must Know About AI and Crypto
This week on the a16z Podcast, we’re sharing a feed drop from Impact Theory with Tom Bilyeu, featuring a wide-ranging conversation with a16z cofounder Ben Horowitz. Artificial intelligence isn’t just a tool — it’s a…
-
Stablecoins & the Future Financial System
a16z Crypto General Partners Ali Yahya, Arianna Simpson, and Erik Torenberg break down what’s actually working in crypto today – starting with the rise of stablecoins as a real-world payments layer. They discuss how stablecoins…
-
How Andreessen Horowitz Disrupted VC & What’s Coming Next
On this episode, taken from The Ben & Marc Show, a16z co-founders Marc Andreessen and Ben Horowitz dive deep into the unfiltered story behind the founding of Andreessen Horowitz—and how they set out to reinvent…
-
Enabling Agents and Battling Bots on an AI-Centric Web
Taken from the AI + a16z podcast, Arcjet CEO David Mytton sits down with a16z partner Joel de la Garza to discuss the increasing complexity of managing who can access websites, and other web apps,…
-
Marc Andreessen on Startup Timing
What if now is the best time in decades to start a company? In this episode, taken from Speedrun, a16z’s accelerator for early-stage founders, Marc Andreessen joins games General Partner Jonathan Lai to make the…
-
Katherine Boyle: How Tech Can Rebuild America
Why does seriousness feel radical today? a16z General Partner Katherine Boyle joins The LaBossiere Podcast to explore what it means to build for the national interest—and why that starts with purpose. Katherine, part of the…
-
Where We Are in the AI Cycle
In this episode of ‘This Week in Consumer’, a16z General Partners Anish Acharya and Erik Torenberg are joined by Steven Sinofsky – Board Partner at a16z and former President of Microsoft’s Windows division – for…
-
Building Cluely: The Viral AI Startup that raised $15M in 10 Weeks
What if virality wasn’t a tactic — but the entire product? In this episode, a16z General Partners Erik Torenberg and Bryan Kim sit down with Roy Lee, cofounder and CEO of Cluely, one of the…
