Newest episodes

A hit like Hamilton can come from nowhere while a sure bet can lose $20 million in a flash. We speak with some of the biggest producers in the game — Sonia Friedman, Jeffrey Seller, Hal Luftig — and learn that there is only one guarantee: the theater owners always win. (Part two of a…

Tried everything to lose weight and nothing’s working? It’s not your fault. According to geneticist Giles Yeo, your body is hardwired to hold onto fat—especially as you age. Yeo breaks down why your metabolism slows, how your genes shape your hunger, and why exercise isn’t the fat-loss fix you think it is. If you’ve been…

中文 Tiếng Việt 中文 Tiếng Việt In this Huberman Lab Essentials episode, I explain how to build endurance and describe targeted protocols to enhance different types of endurance. I discuss how endurance—the ability to sustain effort—requires the coordination of physical and mental systems driven by energy availability, brain willpower, and specific training adaptations in the…

Mark Carney, Canada’s 24th Prime Minister and leader of the Liberal Party, joins Scott to discuss the country’s economic outlook, how Canada fits into a shifting global order, and whether the U.S.-Canada relationship can be repaired amid rising trade tensions. Follow Mark Carney, @MarkJCarney. Algebra of Happiness: thoughts on porn. Learn more about your ad…

中文 Tiếng Việt What if your anxiety isn’t fear, and your trauma might not be real? Dr. Lisa Feldman Barrett reveals how your brain creates emotional illusions. Dr. Lisa Feldman Barrett is a Professor of Psychology and among the top 0.1% of most cited scientists for her revolutionary research in psychology and neuroscience. She is…

Blake Scholl is the founder and CEO of Boom Supersonic. Blake’s problem is this: Can you build a commercial airplane that flies faster than the speed of sound – and that makes economic sense? See omnystudio.com/listener for privacy information.

Rich Barton is the co-founder and co-executive chairman of Zillow, a company transforming how people buy, sell, rent, and finance homes. Before Zillow, Rich founded Expedia within Microsoft in 1994 and successfully spun the company off as a public company in 1999. He served as president, CEO, and board director of Expedia and later co-founded…

Max Jaderberg and Sergei Yakneen from Isomorphic Labs discuss how AI is enhancing drug discovery by treating biology as an information processing system. They share how advanced AI models like AlphaFold 3 are accelerating the pipeline and paving the way for a future of precision medicine.

In today’s world, the battlefield extends far beyond war zones—it’s embedded in our tech stacks, supply chains, and airspace security systems. So who better to solve these modern challenges than those who’ve served on the front lines? Recorded live at the third annual American Dynamism Summit in Washington D.C., this episode features a16z’s Matt Shortal—a…

Can we truly understand what drives desperate families to risk everything at the border? Rachel Rutter, Executive Director of Project Libertad and CNN Hero, delivers a powerful reality check about America’s immigration system. Her organization provides legal representation and wraparound services to unaccompanied immigrant children navigating a complex and often hostile immigration system. Rachel dispels…

Scott answers a big-picture question about the future of nonprofits. Then, he speaks to a listener preparing for a big move after college and offers advice on managing loneliness and finding independence.  Finally, in our Reddit Hotline segment, Scott shares his take on how to lead effectively as a first-time (and remote) manager. Want to…

What happens when one of the most legendary minds in tech delves deep into the real workings of modern AI? A 2-hour long masterclass that you don’t want to miss.   Bret Taylor unpacks why AI is transforming software engineering forever, how founders can survive acquisition (he’s done it twice), and why the true bottlenecks…

Scott and Jessica break down the chaos surrounding Trump’s economic and immigration agendas. First, they dive into Trump’s trade war U-turn: after rattling global markets, he’s hit pause on his “reciprocal” tariff strategy—everywhere but China. They unpack what this 90-day freeze actually means and whether there’s any real strategy behind the whiplash. Next, they turn…