#849: Dr. Michael Levin — Reprogramming Bioelectricity, Updating “Software” for Anti-Aging, Treating Cancer Without Drugs, Cognition of Cells, and Much MoreDr. Michael Levin […]

#848: From Stress to Stillness — Guided Meditation with Zen Master Henry ShukmanThis episode is part of a series called Meditation Monday. The teacher, Henry […]

#847: Steve Young, from Super Bowl MVP to Managing Billions – Hall of Fame 49ers Quarterback on High Performance, Reinvention, Faith, and How to Blend Dreams and PlansStev […]

#846: Permission to Do Nothing — Guided Meditation with Zen Master Henry ShukmanThis episode is part of a series called Meditation Monday. The teacher, Henry […]

#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D’Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition. This episode is brought to you by: Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: https://gusto.com/tim  Seed’s DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic: https://Seed.com/Tim  David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim  Coyote the card game​, which I co-created with Exploding Kittens: https://coyotegame.com * Timestamps: [00:00:00] Who is Dominic D’Agostino? [00:04:37] Ketosis benefits: Quieting the mind, GABA elevation, metabolic psychiatry. [00:09:24] My Lyme disease story: Pseudo-dementia reversed in 3-4 days of ketosis. [00:13:50] Spirochetes are glycolytic: Starve the bug, boost the immune response. [00:19:20] Ketosis and cancer: Slowing glycolytic tumors, enhancing standard care. [00:20:50] My 18-day keto experiment: Mood stabilization, Alzheimer’s prevention hopes. [00:23:19] Metabolic memory: Carryover effects and Valter Longo’s fasting mimicking research. [00:27:11] Intermittent fasting as keto on-ramp: My 2-8 p.m. eating window. [00:29:15] Dom’s budget keto meal: Canned mackerel, MCT oil, apple cider vinegar. [00:33:28] My ketone measurement paradox: Feeling sharp at 0.2 mM readings. [00:36:56] The carburetor analogy: Ketone production vs. utilization explained. [00:38:43] Breath ketones vs. blood ketones: Better indicator in caloric deficit. [00:39:47] Gluconeogenesis fears: Fat, fiber, and salt to slow protein absorption. [00:45:25] The bunless double cheeseburger question: 80 grams of protein in one sitting. [00:49:03] Post-meal walking and GLUT4 activation: Timing your glucose disposal. [00:51:02] CGM and ketone monitor limitations: When your devices gaslight you. [00:58:05] Rabbit starvation and protein-veggie days: Why your body won’t bankroll its own ketosis. [01:05:44] Alzheimer’s prevention: Biomarkers, B12, hsCRP, and metabolic health. [01:09:40] My family history: Letrozole, metabolic dysfunction, and rapid cognitive decline. [01:13:17] Minimum effective dose: 80% of benefits from low-carb Mediterranean. [01:18:56] One week per month protocol: Aggressive calorie cut to ramp ketones. [01:23:12] GKI sweet spot: Target 1-4, aim for 1-2 during intensive weeks. [01:36:22] Exogenous ketones 101: Palatability, tolerability, pharmacokinetics, toxicity. [01:39:21] 1,3-Butanediol warnings: Liver toxicity, NAD depletion, dependency risk. [01:54:22] Intermittent fasting vs. ketogenic breakfast. [01:59:09] My accidental intoxication story. [02:03:23] Dr. Veech tribute: Student of Hans Krebs, ketone ester pioneer. [02:05:08] Fiber on keto: Wild blueberries, broccoli, apples, walnuts. [02:09:58] The tainted gummies incident: Dom’s forensic investigation underway. [02:13:08] Thanks to Dr. Boz and Medifoodz. [02:16:19] Parting thoughts. For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast. For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday. For transcripts of episodes, go to tim.blog/transcripts. Discover Tim’s books: tim.blog/books. Follow Tim: Twitter: twitter.com/tferriss  Instagram: instagram.com/timferriss YouTube: youtube.com/timferriss Facebook: facebook.com/timferriss  LinkedIn: linkedin.com/in/timferriss See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-m […]

#844: Be Still — Guided Meditation with Zen Master Henry ShukmanThis episode is part of a series called Meditation Monday. The teacher, Henry Shukman, has been on my […]

#843: Tactics and Strategies for a 2026 Reboot — Essentialism and Greg McKeown (Repost)Greg McKeown is the author of two New York Times bestsellers, Essentialism: The […]

#842: The Story Behind EpiPen, The Rise of Food Allergies, and What Doctors Got WrongThis time around, we have an experimental format, featuring the first episode of […]

#841: Arthur Brooks — Finding The Meaning of Your Life, The Poet’s Protocol, The Holy Half-Hour, and Why Your Suffering is SacredArthur C. Brooks is a professor at the […]

#840: Bill Gurley — Investing in The AI Era, 10 Days in China, and Important Life Lessons from Bob Dylan, Jerry Seinfeld, MrBeast, and MoreBill Gurley (@bgurley) is a […]

#839: Dr. Fei-Fei Li, The Godmother of AI — Asking Audacious Questions, Civilizational Technology, and Finding Your North StarDr. Fei-Fei Li (@drfeifei) is the […]

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de MelloWelcom […]

#837: How to Simplify Your Life in 2026 — New Tips from Derek Sivers, Seth Godin, and Martha BeckAs we head into the new year, many of us feel like we’re drowning in i […]

#836: The 4-Hour Workweek Principles — 13 Mistakes to Avoid, The Art of Mini-Retirements, and Navigating the Dizziness of FreedomThis time around, we have a bit of a […]

#835: Ben Patrick (KneesOverToesGuy) — 20-Minute Workouts That Produce Wild Results, From Chronic Knee Pain to Dunking Basketballs, Lessons from Charles Poliquin, Bulletproofing the Lower Body, and MoreBen Patrick, better known as “Kneesovertoesguy” (@kneesovertoesguy), is the founder of Athletic Truth Group (ATG), an online and brick-and-mortar training system rooted in rehabilitative strength and joint health. After years of debilitating knee and shin pain (including multiple surgeries), he rebuilt his body and performance, going from a sub-20″ vertical to a documented 42″ leap. This episode is brought to you by: Momentous high-quality creatine for cognitive and muscular support: https://livemomentous.com/Tim (Code TIM for 35% off your first subscription.) Monarch track, budget, plan, and do more with your money: Monarch.com/Tim (50% off your first year at monarchmoney.com with code TIM) David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim (Buy 4 cartons, get the 5th free.) My workout with Ben: https://youtu.be/xpM4V6O9f6w Timestamps: [00:00:00] Who is Ben Patrick? [00:02:32] How Ben went from Old Man Patrick to Knees Over Toes Guy. [00:06:37] Backward sled dragging for safe strength building and rehab. [00:13:14] Full range of motion squatting (deep squats vs. 90-degree limitation). [00:16:30] “Strength is gained in the range it is trained.” — Charles Poliquin [00:18:50] ATG split squat (front foot elevated split squat). [00:19:53] Heel elevation and counterbalancing techniques. [00:24:26] Ben’s mother’s transformation — from hip deterioration to sprinting at age 71. [00:27:36] Ben’s vertical jump progression — unable to grab rim in high school to dunking at 34. [00:28:14] Most effective exercises Ben’s mom might recommend. [00:29:54] Ben and I reflect on what Charles Poliquin (RIP) gave to us. [00:36:36] How backwards sled pulling became a revered exercise. [00:39:12] Mr. Universe Bob Gajda’s contributions to Ben’s regimen. [00:42:16] ATG prioritizes offering American-made products when possible. [00:43:14] Tibialis raises without equipment. [00:45:37] Why I included the ATG wrist bar in a recent 5-Bullet Friday. [00:48:32] Ben’s videos he most recommends. [00:54:48] Applying the minimum effective dose (MED) for maximum results in any endeavor. [00:59:55] What I would include in The 4-Hour Body if it were written or revised today. [01:01:13] A space-saving alternative for people who want to enjoy the benefits of sled work. [01:01:57] Real examples of high-yield workouts that require a low investment of time. [01:05:59] Ben’s basketball warmup protocols. [01:06:59] Regularly skip leg day? Try Arnold Schwarzenegger’s one simple trick. [01:08:49] Maintaining integrity in the ever-fickle world of content creation. [01:32:18] Parting thoughts. * For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast. For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday. For transcripts of episodes, go to tim.blog/transcripts. Discover Tim’s books: tim.blog/books. Follow Tim: Twitter: twitter.com/tferriss  Instagram: instagram.com/timferriss YouTube: youtube.com/timferriss Facebook: facebook.com/timferriss  LinkedIn: linkedin.com/in/timferriss See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://a […]

#834: David Baszucki, Co-Founder of Roblox — The Path to 150M+ Daily Users, Critical Business Decisions, Ketogenic Therapy for Brain Health, Daily Routines, The Roblox Economy, and MoreDavid Baszucki is the founder and CEO of Roblox. TIME named Roblox one of the “100 Most Influential Companies,” and it has been recognized by Fast Company for innovation on their “Most Innovative Companies” and “Most Innovative Companies in Gaming” lists. This episode is brought to you by: Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: https://Qlosi.com/Tim AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim Wealthfront high-yield cash account: https://Wealthfront.com/Tim New clients get 3.30% base APY from program banks + additional  0.75% boost for 3 months on your uninvested cash (max $150k balance). Terms and conditions apply. The Cash Account offered by Wealthfront Brokerage LLC (“WFB”) member FINRA/SIPC, not a bank. The base APY as of 1/30/26 is representative, can change, and requires no minimum. Tim Ferriss, a non-client, receives compensation from WFB for advertising and holds a non-controlling equity interest in the corporate parent of WFB, which creates a conflict of interest.  Individual experiences and outcomes will differ. Instant withdrawals may be limited by your receiving firm and other factors. Investment advisory services provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, not bank-guaranteed or FDIC-insured, and may lose value. Timestamps: [00:00:00] Start. [00:01:48] Kicking off with custom kettlebells. [00:03:00] How David and I connected through Dominic D’Agostino and metabolic health research. [00:04:30] Matthew Baszucki’s eight-year journey with bipolar disorder before keto breakthrough. [00:08:14] Rescuing Matthew from the streets with a strategic hospital admission. [00:18:18] Matthew’s disappearance from his mother’s perspective. [00:19:37] Understanding how the ketogenic diet helps people with bipolar disorder. [00:24:21] Meeting the challenges of ketogenic diet compliance. [00:30:06] Measuring ketone levels. [00:32:17] The clandestine Canadian CKM smuggling ring. [00:33:07] The calm optimism, mental clarity, and reduced sleep requirements of ketosis. [00:35:19] Breath hold experiments. [00:37:44] Optimizing my sleep and minimizing my OCD on ketosis. [00:40:18] How exogenous ketones improve verbal acuity of relatives with Alzheimer’s [00:41:49] Lyme disease and ketosis. [00:44:37] Talk therapy vs. mechanical therapy: Fixing the machinery first. [00:45:47] Dangers of talk therapy without physiological foundation: Learned helplessness. [00:46:49] Atmospheric Calm playlist: Ambient music for focus and productivity. [00:49:16] How Roblox fits in with human connection evolution to the tune of 120 million daily users. [00:52:50] Emergent games within the Roblox ecosystem. [00:54:32] Roblox’s safety infrastructure: Built for all ages from day one. [00:55:24] Future of 3D work: Virtual meetings replacing video calls, concerts, and political rallies. [00:56:57] The inevitability of innovation. [00:58:07] From early revenue challenges to a creator community earning over $1 billion a year. [01:02:52] Taking economic inspiration from Adam Smith. [01:03:54] Building the successful Robux system with a 20-person team in three months. [01:10:17] How does Roblox guard against IP theft among its digital creators? [01:14:32] Best company decisions made at Roblox thus far. [01:19:35] Missteps and mistakes. [01:21:07] When intuitive tech predictions pay off. [01:25:49] David’s favorite niche Roblox games. [01:28:41] Roblox kid safety: Filtered communication, parental controls, future AI age estimation, and clustering. [01:32:02] Roblox AI infrastructure: Hundreds of models for safety, translation, 3D creation, and procedurally generated dreaming. [01:33:33] Predictions: Sci-fi becoming reality, holodeck timeline, AI movies in 3-5 years, photorealistic virtual concerts. [01:37:24] Product development and challenges of being a public company CEO. [01:41:35] David’s self-care routine. [01:45:20] Roblox wellness: CGMs for all employees, snack labeling system, employee transformations. [01:47:11] Exploratory reading. [01:49:32] “Feed Your Head”: David’s Jefferson Airplane-inspired billboard. [01:50:24] Whole cream vs. half-and-half for coffee and other parting thoughts. * For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast. For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday. For transcripts of episodes, go to tim.blog/transcripts. Discover Tim’s books: tim.blog/books. Follow Tim: Twitter: twitter.com/tferriss  Instagram: instagram.com/timferriss YouTube: youtube.com/timferriss Facebook: facebook.com/timferriss  LinkedIn: linkedin.com/in/timferriss See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not […]

#833: Jack Canfield — Selling 600+ Million Books, Success Principles, and How He Made The 4-Hour Workweek HappenJack Canfield is the coauthor of more than two hundred […]

#832: The Return of The Lion Tracker — Boyd Varty on The Wild Man Within, Nature’s Hidden Wisdom, and How to Feel Fully AliveBoyd Varty is the founder of Track Your […]

#831: Frank Miller, Comic Book Legend — Creative Process, The Dark Knight Returns, Sin City, 300, and Much MoreFrank Miller is regarded as one of the most influential and […]

#830: Nick Kokonas and Richard Thaler, Nobel Prize Laureate — Realistic Economics, Avoiding The Winner’s Curse, Using Temptation Bundling, and Going Against the EstablishmentRichard H. Thaler is the 2017 recipient of the Nobel Memorial Prize in Economic Sciences for his contributions to behavioral economics and the Charles R. Walgreen Distinguished Service Professor of Behavioral Science and Economics at the University of Chicago Booth School of Business. He is the New York Times bestselling co-author of Nudge: Improving Decisions About Health, Wealth, and Happiness and the author of Misbehaving: The Making of Behavioral Economics. His new book is The Winner’s Curse: Behavioral Economics Anomalies, Then and Now.  My co-host for this conversation is Nick Kokonas. Nick is an entrepreneur, investor, and author best known as the co-founder of The Alinea Group (sold in 2024) and the reservation platform Tock, which is now owned by American Express. This episode is brought to you by: Seed’s DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic: https://Seed.com/Tim (Use code 25TIM for 25% off your first month’s supply) ExpressVPN high-speed, secure, and anonymous VPN service: https://www.expressvpn.com/tim (get 4 months free on their annual plans) AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.) Timestamps: [00:00:00] Start. [00:02:33] First principles: What is economics, really? [00:04:18] The “max” assumption and agents as optimizers. [00:06:41] Rationality in models: Solving problems like an economist would. [00:07:29] “Meh” vs “Max” — shortcuts instead of optimization. [00:08:06] Selfishness, fairness, and self-control in economic models. [00:10:08] Milton Friedman’s “as if” defense. [00:12:36] The cashew nuts story: Origin of behavioral economics. [00:14:02] Removing choice and status quo bias. [00:17:31] The case for Americans needing forced savings. [00:19:34] Academic resistance: Psychologists laughing at economic theory. [00:24:37] Loss aversion: Disease cure experiment. [00:27:04] Endowment effect: Coffee mug experiment. [00:29:45] Restaurant reservations and the power of deposits. [00:31:05] Fairness research: Snow shovels and blizzards. [00:32:50] Uber surge pricing and the 9/11 thought experiment. [00:34:37] Behavioral economics in one sentence. [00:35:00] Nudges: 401(k) auto-enrollment case study. [00:37:46] The fly in the urinal and nudge durability. [00:39:07] Lakeshore Drive lines: Making safety easy. [00:41:30] Choice architecture: Good nudges vs. malicious nudges. [00:42:40] Online gambling and Robinhood’s gamification. [00:45:51] Lessons learned from teaching decision-making for 40 years. [00:46:52] Winner’s curse: The jar of coins demonstration. [00:49:04] ARCO engineers discover the winner’s curse in oil bidding. [00:50:11] Writing papers as competitive strategy. [00:52:31] Amos Tversky’s note: People learn through stories. [00:53:44] Overconfidence: Amazon River and CFO predictions. [00:55:59] NFL draft: 53% success rate (barely better than coin flips). [00:57:12] Trading down in the draft as optimal strategy. [00:59:26] Applying behavioral insights to daily habits. [01:01:04] The law of one price and restaurant deposit resistance. [01:02:39] Being a chef doesn’t automatically make you a good businessperson. [01:03:33] Sports analytics: The three-point shot revolution. [01:04:29] Michael Jordan vs Steve Kerr: 50% three-point shooting. [01:05:56] Finding $20 bills on the street. [01:06:35] Mental accounting: Money in jeans feels like a windfall. [01:07:50] Obama stimulus: Lump sum vs. spread out payments — why does it matter? [01:09:58] Airline baggage fees: “There’s a guy who owns that.” [01:11:43] Sunk cost fallacy: The dessert we don’t need. [01:12:37] Nick’s $500 wine example and building Tock on sunk costs. [01:14:41] Richard’s daughter and the baseball/concert tickets experiment. [01:16:05] Temptation bundling: Using cognitive biases for self-improvement. [01:19:06] Big data and natural experiments in the real world. [01:19:50] Mental accounting in action: Premium gas during the financial crisis. [01:22:34] Amazon’s hundred-PhD economics department. [01:23:48] The pragmatic reason Richard invented behavioral economics. [01:25:47] Strategy: Corrupt the youth, not change old minds. [01:27:06] The behavioral economics summer camp running since 1994. [01:28:12] The “Anomalies” column in Journal of Economic Perspectives. [01:29:44] Citations matter: Writing articles people can understand. [01:30:31] Availability bias: Homicides vs. suicides. [01:31:47] Kahneman and Tversky: The reason for everything. [01:33:11] Systematic bias vs. random errors. [01:34:08] Amos’ dinner trap: Everyone you know is dumb, except your models. [01:37:19] Michael Lewis’ The Undoing Project. [01:38:11] Daniel Kahneman’s assisted suicide decision as peak-end rule applied to life itself. [01:45:11] What keeps Richard going? [01:46:44] Why the updated version of The Winner’s Curse should appeal to economists and everyday humans. [01:49:58] Parting thoughts. * For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast. For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday. For transcripts of episodes, go to tim.blog/transcripts. Discover Tim’s books: tim.blog/books. Follow Tim: Twitter: twitter.com/tferriss  Instagram: instagram.com/timferriss YouTube: youtube.com/timferriss Facebook: facebook.com/timferriss  LinkedIn: linkedin.com/in/timferriss See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-m […]